William R Horne

US Patent:

6682739, Jan 27, 2004

Filed:

Jul 28, 2000

Appl. No.:

09/627775

Inventors:

Mark I. Greene - Penn Valley PA
Ramachandran Murali - Drexel Hill PA
Kazuhiro Aoki - Narashino, JP
William Carle Horne - Branford CT
Roland Baron - Guilford CT

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

A61K 3900

US Classification:

4241851, 424 851, 4241841, 4241921, 4241781, 514 12, 514 2, 514 8, 514885, 530350, 530351

Abstract:

Methods of inhibiting osteoclastogenesis and the activity of osteoclasts are disclosed. Methods of treating patients who have diseases characterized bone loss are disclosed. The present invention also provides peptides and peptide analogues designed from a binding loop of a member of the tumor necrosis factor receptor (TNF-R) superfamily. According to the methods, an amount of an inhibitor effective to inhibit osteoclastogenesis is administered to the patient. Methods of modulating dendritic cell maturation, T cell proliferation, and/or CD40 receptor systems in an individual are disclosed. The methods comprise the step of administering to the individual an amount of an inhibitor effective to modulating dendritic cell maturation, T cell proliferation, and/or CD40 receptor systems.