William T Horne

US Patent:

8642536, Feb 4, 2014

Filed:

Oct 14, 2009

Appl. No.:

12/578993

Inventors:

William S. Horne - Pittsburgh PA, US
Samuel H. Gellman - Madison WI, US
Lisa M. Johnson - Marshall MN, US

Assignee:

Wisconsin Alumni Research Foundation - Madison WI

International Classification:

A01N 37/18
A61K 38/55
A61P 31/18
C12N 5/071
A61K 38/00
C07K 5/00
C07K 7/00
C07K 16/00
C07K 17/00
A61K 38/04

US Classification:

514 41, 435366, 530324, 530325, 530326, 530333

Abstract:

Described is a method of fabricating biologically active, unnatural polypeptides. The method includes the steps of selecting a biologically active polypeptide or biologically active fragment thereof having an amino acid sequence comprising α-amino acid residues, and fabricating a synthetic polypeptide that has an amino acid sequence that corresponds to the sequence of the biologically active polypeptide, but wherein about 14% to about 50% of the α-amino acid residues found in the biologically active polypeptide or fragment of step (a) are replaced with β-amino acid residues, and the α-amino acid residues are distributed in a repeating pattern.