William Daniel Lawrence

US Patent:

41545346, May 15, 1979

Filed:

Jul 28, 1977

Appl. No.:

5/819770

Inventors:

William A. Lawrence - Columbus OH
John A. O'Dea - Columbus OH

Assignee:

The Jaeger Machine Company - Columbus OH

International Classification:

B28C 716

US Classification:

366 42

Abstract:

A transit concrete mixer includes a drum which is mounted for discharge either forwardly or reversely of the vehicle and has two sets of flights for two-stage concrete loading and discharging. One set of flights is particularly useful for carrying the aggregate from the base of the drum upwardly along the major axis of the drum and a second set of flights is adapted for receiving the aggregate and transporting it through the remaining length of the drum to the discharge opening of the drum. Thus, for relatively stiff, low slump aggregates which are useful in paving and for formless type useage, the concrete mixer unit is fully adaptable for such low slump values. Conversely, the same set of flights is adapted for charging and discharging relatively high slump values which are utilized for form type applications. Additionally, the discharge opening of the drum is controlled in accordance with the slump of the discharging concrete mix or aggregate so that for relatively stiff and low order slump values the aggregate is dischargeable without impediment and, conversely, for more fluid, high slump aggregates, the discharge opening is controllable by an adjustably placeable weir which precludes too rapid emergence of the slump for given drum rotations with the described combination of flights. The transit mixer unit is, therefore, the first practicable all-purpose transit mixer.

US Patent:

43186211, Mar 9, 1982

Filed:

May 9, 1977

Appl. No.:

5/794750

Inventors:

William A. Lawrence - Columbus OH
John A. O'Dea - Columbus OH

Assignee:

Jaeger Machine Company - Columbus OH

International Classification:

B28C 542

US Classification:

366 41

Abstract:

A transit concrete mixer is provided having a displaceable charging hopper which may be moved between a charging position wherein a discharge conduit thereof projects into the interior of the mixer drum and a relatively displaced position where the discharge conduit is removed from the drum to facilitate discharge of concrete from the drum. The charging hopper is pivotally attached to a support structure which also carries the rear end portion of the mixer drum and is selectively movable in a vertical plane about a horizontal axis. The relative location of the horizontal axis for pivoting movement of the charging hopper is located with respect to the terminal end of the hopper's discharge conduit such that the hopper and its associated conduit may be swung from one position to the other without interference with the mixer drum and its interiorally mounted blade elements. A hydraulic actuating ram is provided to facilitate the swinging movement of the charging hopper. A discharge stop plate is also provided in the combination with this plate attached to and carried by the charging hopper for concurrent displacing movement between a normal position closely adjacent the rear end of the mixer drum and a position relatively remote thereto.

US Patent:

20220244275, Aug 4, 2022

Filed:

Jul 2, 2020

Appl. No.:

17/622048

Inventors:

- Columbus OH, US
William Lawrence - Columbus OH, US
Diego Alzate Correa - Columbus OH, US

International Classification:

G01N 33/68
A61K 31/713

Abstract:

As disclosed herein, the skin can dispatch signals to the brain in the form of exosomes, referred to herein as a “skin-brain axis.” Therefore, disclosed herein is a method for diagnosing a brain disease, disorder, or injury in a subject that involves isolating exosomes from the subject and assaying the exosomes for the presence of one or more biomarkers of the disease, disorder, or injury. Also disclosed are methods of treating a subject with a brain disease, disorder, or injury that involves engineering the skin of the subject to produce therapeutic exosomes. Also disclosed are methods of collecting skin-produced exosomes and loading them with therapeutic cargo that can treat one or more diseases, disorders, or injuries of the brain. Also disclosed herein is a method to reduce exosomal release from the skin to reducing trafficking to the brain.