William G Mcbride

US Patent:

8545809, Oct 1, 2013

Filed:

Dec 12, 2011

Appl. No.:

13/323139

Inventors:

Christopher A. D'Souza - Pomona NY, US
William J. McBride - Boonton NJ, US
David M. Goldenberg - Mendham NJ, US

Assignee:

Immunomedics, Inc. - Morris Plains NJ

International Classification:

A61K 51/00
A61M 36/14

US Classification:

424 189, 424 111, 424 153, 424 165, 424 181, 424 185, 534 7, 534 14

Abstract:

The present application discloses compositions and methods of synthesis and use of F or F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the F or F is conjugated to a targeting molecule by formation of a complex with a group IIIA metal and binding of the complex to a bifunctional chelating agent, which may be directly or indirectly attached to the targeting molecule. In other embodiments, the F or F labeled moiety may comprise a targetable construct used in combination with a bispecific antibody to target a disease-associated antigen. The disclosed methods and compositions allow the simple and reproducible labeling of molecules at very high efficiency and specific activity in 30 minutes or less. In preferred embodiments, the labeled molecule may be used for imaging in a subject without purification after labeling.