William E Parsons

US Patent:

6362201, Mar 26, 2002

Filed:

Mar 1, 2000

Appl. No.:

09/516775

Inventors:

Robert K. Baker - Cranford NJ
William H. Parsons - Edison NJ
Kathleen Rupprecht - Cranford NJ

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

A61K 31445

US Classification:

514326, 514212, 514213, 514255, 514278, 514309, 514319, 514320, 514323, 514336, 514339, 514343, 514414, 514922, 540595, 540602, 544392, 546148, 5462714, 5462764, 5462774, 5462804, 5462824, 546 16, 546 17, 546196, 546201, 546205, 546208, 548229, 548465, 548565, 548950

Abstract:

The present invention is directed to pyrrolidine compounds of the formula I: (wherein R , R , R , R , R , and R are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.

US Patent:

6372764, Apr 16, 2002

Filed:

Mar 1, 2000

Appl. No.:

09/516754

Inventors:

Jianming Bao - Scotch Plains NJ
Robert K. Baker - Cranford NJ
William H. Parsons - Edison NJ
Kathleen Rupprecht - Cranford NJ

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

A61K 31445

US Classification:

514326, 514212, 514213, 5142355, 514255, 514278, 514319, 514323, 514336, 514339, 514343, 514414, 514422, 540595, 540602, 544129, 544372, 546 16, 546 17, 546201, 546205, 546208, 546209, 5462714, 5462764, 5462774, 5462807, 5462824, 548229, 548465, 548565, 548950

Abstract:

The present invention is directed to pyrrolidine compounds of the formula I: (wherein R , R , R , R , R , and R are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.

US Patent:

6437165, Aug 20, 2002

Filed:

Aug 30, 2001

Appl. No.:

09/942411

Inventors:

Suzanne Mandala - Scotch Plains NJ
James Bergstrom - Neshanic Station NJ
Richard Hajdu - Old Bridge NJ
Hugh Rosen - Springfield NJ
William Parsons - Belle Mead NJ
Deborah J. Card - Somerset NJ
Malcolm Maccoss - Freehold NJ
Rupprecht Kathleen - Cranford NJ

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

A61K 31662

US Classification:

558169, 558 70, 558166, 514114

Abstract:

Immunoregulatory compounds are disclosed of the formula: as well as the pharmaceutically acceptable salts and hydrates thereof, are disclosed. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.

US Patent:

6489354, Dec 3, 2002

Filed:

Mar 1, 2000

Appl. No.:

09/516771

Inventors:

Jianming Bao - Scotch Plains NJ
Robert K. Baker - Cranford NJ
William H. Parsons - Edison NJ
Kathleen Rupprecht - Cranford NJ

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

A61K 3140

US Classification:

514422, 51421016, 51421019, 5142102, 514215, 51421702, 51421703, 51421708, 5142355, 51425213, 51425309, 514278, 514309, 514319, 514323, 514326, 514336, 514339, 514343, 514366, 514408, 514409, 514410, 514414, 514443, 540595, 540602, 544129, 544372, 546 16, 546 17, 546200, 546208, 546209, 5462764, 5462774, 5462797, 548416, 548517, 548565, 548950

Abstract:

The present invention is directed to pyrrolidine compounds of the formula I: (wherein R , R , R , R , R , and R are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.

US Patent:

6498165, Dec 24, 2002

Filed:

Jun 26, 2000

Appl. No.:

09/604305

Inventors:

Helen M. Armstrong - Westfield NJ
Richard Beresis - New York NY
Joung L. Goulet - Westfield NJ
Mark A. Holmes - Middlesex NJ
Xingfang Hong - Westfield NJ
Sander G. Mills - Scotch Plains NJ
William H. Parsons - Belle Mead NJ
Peter J. Sinclair - Scotch Plains NJ
Mark G. Steiner - East Brunswick NJ
Frederick Wong - Glen Ridge NJ
Dennis M. Zaller - Scotch Plains NJ

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

A61K 31505

US Classification:

514275, 514256, 5142581, 544330, 544331

Abstract:

Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same, which are inhibitors of tyrosine kinase enzymes, and as such are useful in the prophylaxis and treatment of protein tyrosine kinase-associated disorders, such as immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to play a role, such as cancer, angiogensis, atheroscelerosis, graft rejection, rheumatoid arthritis and psoriasis.

US Patent:

6545023, Apr 8, 2003

Filed:

Aug 16, 2001

Appl. No.:

09/931454

Inventors:

Lihu Yang - Edison NJ
Gabor Butora - Martinsville NJ
William H. Parsons - Belle Mead NJ
Alexander Pasternak - Princeton NJ

Assignee:

Merck Co., Inc.

International Classification:

A61K 31445

US Classification:

514331, 514317, 546192, 546229, 546233

Abstract:

The present invention is directed to compounds of the formula I: (wherein R , R , R , R , R , R and X are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.

US Patent:

6632836, Oct 14, 2003

Filed:

Oct 21, 1999

Appl. No.:

09/422143

Inventors:

Robert K. Baker - Cranford NJ
Jianming Bao - Scotch Plains NJ
Jennifer Chee - Princeton NJ
Maria L. Garcia - Edison NJ
Gregory J. Kaczorowski - Edison NJ
Frank Kayser - Hoboken NJ
Andrew Kotliar - Highland Park NJ
Chou Juitsai Liu - Fanwood NJ
Shouwu Miao - Edison NJ
William H. Parsons - Belle Mead NJ
Kathleen M. Rupprecht - Cranford NJ
William A. Schmalhofer - South Plainfield NJ
Christopher F. Claiborne - Lansdale PA
David A. Claremon - Maple Glen PA
Nigel Liverton - Harleysville PA
Wayne J. Thompson - Lansdale PA

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

A61K 3116

US Classification:

514539, 514563, 514616, 514622, 560 42, 562451, 564158, 564176

Abstract:

The present invention relates to a class of carbocyclic compounds of Formula I that are useful as potassium channel inhibitors to treat autoimmune disorders, cardiac arrhythmias, and the like.

US Patent:

7326726, Feb 5, 2008

Filed:

Mar 12, 2004

Appl. No.:

10/799230

Inventors:

Prasun K. Chakravarty - Edison NJ, US
Louis L. Zuegner III, legal representative - Flemington NJ, US
Brenda Palucki - Hillsborough NJ, US
Min K. Park - Whippany NJ, US
William H. Parsons - Belle Mead NJ, US
Bishan Zhou - Hoboken NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31/41
C07D 249/08

US Classification:

514359, 5482694

Abstract:

Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.