William T Rothwell

US Patent:

20210379202, Dec 9, 2021

Filed:

Aug 20, 2021

Appl. No.:

17/407782

Inventors:

- Philadelphia PA, US
Christian Hinderer - New Orleans LA, US
William Thomas Rothwell - Philadelphia PA, US

International Classification:

A61K 48/00
A61K 39/395
C07K 16/10
C07K 16/18
C12N 15/63
A61P 25/28
C12N 7/00
C12N 15/86

Abstract:

A composition comprising at least one AAV vector formulated for intrathecal delivery to the central nervous system is described. The composition comprises at least one expression cassette which contains sequences encoding an immunoglobulin construct linked to expression control sequences therefor and a pharmaceutically acceptable carrier. The immunoglobulin construct may be an immunoglobulin modified to have decreased or no measurable affinity for neonatal Fc receptor (FcRn).

US Patent:

20200368368, Nov 26, 2020

Filed:

Aug 6, 2020

Appl. No.:

16/986946

Inventors:

- Philadelphia PA, US
William Thomas Rothwell - Philadelphia PA, US
Christian Hinderer - New Orleans LA, US

International Classification:

A61K 48/00
C07K 16/32
A61K 9/00

Abstract:

A composition comprising at least one AAV vector formulated for central nervous system delivery is described. The composition comprises at least one expression cassette which contains sequences encoding an anti-neoplastic immunoglobulin construct for delivery to the brain operably linked to expression control sequences therefor and a pharmaceutically acceptable carrier. The anti-neoplastic immunoglobulin construct may be an immunoglobulin modified to have decreased or no measurable affinity for neonatal Fc receptor (FcRn). Also provided are methods of using these constructs in preparing pharmaceutical compositions and uses thereof in anti-neoplastic regimens, particularly for primary and/or metastatic cancers of the brain.

US Patent:

20180339065, Nov 29, 2018

Filed:

Oct 27, 2016

Appl. No.:

15/771481

Inventors:

- Philadelphia PA, US
Christian Hinderer - Philadelphia PA, US
William Thomas Rothwell - Philadelphia PA, US

International Classification:

A61K 48/00
C12N 7/00
C12N 15/86

Abstract:

A composition comprising at least one AAV vector formulated for intrathecal delivery to the central nervous system is described. The composition comprises at least one expression cassette which contains sequences encoding an immunoglobulin construct linked to expression control sequences therefor and a pharmaceutically acceptable carrier. The immunoglobulin construct may be an immunoglobulin modified to have decreased or no measurable affinity for neonatal Fc receptor (FcRn).

US Patent:

20170043035, Feb 16, 2017

Filed:

Apr 24, 2015

Appl. No.:

15/306413

Inventors:

- Philadelphia PA, US
William Thomas Rothwell - Philadelphia PA, US
Christian Hinderer - Philadelphia PA, US

International Classification:

A61K 48/00
A61K 9/00
C07K 16/32

Abstract:

A composition comprising at least one AAV vector formulated for central nervous system delivery is described. The composition comprises at least one expression cassette which contains sequences encoding an anti-neoplastic immunoglobulin construct for delivery to the brain operably linked to expression control sequences therefor and a pharmaceutically acceptable carrier. The anti-neoplastic immunoglobulin construct may be an immunoglobulin modified to have decreased or no measurable affinity for neonatal Fc receptor (FcRn). Also provided are methods of using these constructs in preparing pharmaceutical compositions and uses thereof in anti-neoplastic regimens, particularly for primary and/or metastatic cancers of the brain.