A strategy for effecting virus resistance in plants causes the transcription in the plant cells of negative RNA strands which are substantially complementary to a target RNA strand. The target RNA strand can be an mRNA transcript created in gene expression, a viral RNA, or other RNA present in the plant cells. The negative RNA strand is complementary to at least a portion of the target RNA strand to inhibit its activity in vivo.
Rustum S. Boyce - San Francisco CA, US Natalia Aurrecoechea - Oakland CA, US Daniel Chu - Santa Clara CA, US Aaron Smith - Union City CA, US Christopher R. Conlee - Morrisville NC, US Brian D. Thompson - Chapel Hill NC, US Judith de Armas Kuntz - Raleigh NC, US David L. Musso - Raleigh NC, US Kevin K. Barvian - Morrisville NC, US Stephen A. Thomson - Durham NC, US William R. Swain - Durham NC, US Kien S. Du - Durham NC, US Brian A. Chauder - Raleigh NC, US Jason D. Speake - Cary NC, US Michael J. Bishop - Chapel Hill NC, US
Assignee:
Novartis Vaccines and Diagnostics, Inc. - Emeryville CA
A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structure IA, IB, and IC where the values of the variables are defined herein.
Rustum S. BOYCE - San Francisco CA, US Natalia Aurrecoechea - Oakland CA, US Daniel Chu - Santa Clara CA, US Aaron Smith - Union City CA, US Christopher R. Conlee - Morrisville NC, US Brian D. Thompson - Chapel Hill NC, US Judith de Armas Kuntz - Raleigh NC, US David L. Musso - Raleigh NC, US Kevin K. Barvian - Morrisville NC, US Stephen A. Thomson - Durham NC, US William R. Swain - Durham NC, US Kien S. Du - Durham NC, US Brian A. Chauder - Raleigh NC, US Jason D. Speake - Cary NC, US Michael J. Bishop - Chapel Hill NC, US
A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structures VA, VB, VIIA and VIIB where the values of the variables are defined herein.
Chicago, ILStage Director Past: General Director at Greensboro Opera, General Director / Artistic Director at Opera... William Swain was engaged as General Director of Greensboro Opera in July 2008 and served until his resignation in December, 2008, supervising strategic... William Swain was engaged as General Director of Greensboro Opera in July 2008 and served until his resignation in December, 2008, supervising strategic planning, fund raising, development, marketing, budgets, education and outreach, and HR. He managed all aspects of production, technical staff, and...