William Matthew Sweeney

US Patent:

8356606, Jan 22, 2013

Filed:

May 30, 2008

Appl. No.:

12/155227

Inventors:

Tapashi Sengupta - Barrington IL, US
Munmaya K. Mishra - Richmond VA, US
William R. Sweeney - Richmond VA, US
Douglas A. Fernandez - Richmond VA, US

Assignee:

Philip Morris USA Inc. - Richmond VA

International Classification:

A24B 15/00

US Classification:

131309, 131290, 131352

Abstract:

A method of providing a comestible plant material taken orally by coating a micronized plant material with a first layer of polysaccharides or proteins, then a second layer of polysaccharides or proteins is disclosed. A bi-encapsulated plant material produced by this process is also disclosed.

US Patent:

20080167382, Jul 10, 2008

Filed:

Sep 13, 2007

Appl. No.:

11/900722

Inventors:

William E. Sweeney - Waukesha WI, US
Ellis D. Avner - Milwaukee WI, US
Richard J. Roman - Brookfield WI, US

International Classification:

A61K 31/155
A61P 35/00
A61P 13/12

US Classification:

514637

Abstract:

The present invention provides a method for preferentially reducing the proliferation of cystic epithelial cells in the kidney or bile duct in a mammal in need thereof by administering a 20-HETE synthesizing enzyme inhibitor or a 20-HETE antagonist to the mammal in an amount sufficient to preferentially reduce the proliferation of cystic epithelial cells over normal epithelial cells such as tubule epithelial cells in the kidney or bile duct. The present invention also provides a method for preventing or treating autosomal dominant polycystic kidney disease (ADPKD), autosomal recessive polycystic kidney disease (ARPKD), ARPKD associated congenital hepatic fibrosis, ARPKD associated Caroli's disease, or cholangiocarcinoma in a mammal in need thereof by administering a 20-HETE synthesizing enzyme inhibitor or a 20-HETE antagonist to the mammal in an amount sufficient to prevent or treat the disease.

US Patent:

20100303969, Dec 2, 2010

Filed:

Dec 28, 2009

Appl. No.:

12/648154

Inventors:

Tapashi Sengupta - Barrington IL, US
Munmaya K. Mishra - Manakin Sabot VA, US
William R. Sweeney - Richmond VA, US

Assignee:

Philip Morris USA Inc. - Richmond VA

International Classification:

A23P 1/04
A23F 3/14
A23F 5/10
A24B 15/18
A24B 3/14

US Classification:

426 96, 426271, 131354, 131370

Abstract:

A process for preparing an orally-enjoyable film of encapsulated plant material includes combining particles of finely divided plant material, a first coating material, and a second coating material, then inducing gelation to form a gel matrix of the particles coated with the first coating material embedded in the second coating material, followed by forming a film from the gel matrix. Also disclosed is a film of coated particles of finely-divided plant material, made of a gel matrix of plant material at least partially surrounded by a first coating material and embedded in a second coating material.

US Patent:

20110083681, Apr 14, 2011

Filed:

Jun 1, 2010

Appl. No.:

12/791440

Inventors:

Tapashi Sengupta - Barrington IL, US
Douglas A. Fernandez - Richmond VA, US
Munmaya K. Mishra - Manakin Sabot VA, US
William R. Sweeney - Richmond VA, US

Assignee:

Philip Morris USA Inc. - Richmond VA

International Classification:

A24B 15/40

US Classification:

131275, 131310

Abstract:

A process for preparing coated particles of a plant material includes: (a) combining plant material particles and a protein in a liquid medium, wherein the protein adsorbs onto at least a portion of a surface of the particles to form a first layer; and (b) mixing a polysaccharide including a pectin with the liquid medium, so that the polysaccharide adsorbs onto at least a portion of a surface of the first layer to form a second layer. In addition, a palatable product comprising at least one coated particle prepared by this process is described.

US Patent:

20140329811, Nov 6, 2014

Filed:

Jun 12, 2014

Appl. No.:

14/302545

Inventors:

William E. Sweeney - Waukesha WI, US
Ellis D. Avner - Milwaukee WI, US
Richard J. Roman - Brookfield WI, US

International Classification:

A61K 31/5375
A61K 31/18
A61K 31/201
A61K 31/202
A61K 31/155
A61K 31/20

US Classification:

5142312, 514633, 514558, 514560, 514601

Abstract:

The present invention provides a method for preferentially reducing the proliferation of cystic epithelial cells in the kidney or bile duct in a mammal in need thereof by administering a 20-HETE synthesizing enzyme inhibitor or a 20-HETE antagonist to the mammal in an amount sufficient to preferentially reduce the proliferation of cystic epithelial cells over normal epithelial cells such as tubule epithelial cells in the kidney or bile duct. The present invention also provides a method for preventing or treating autosomal dominant polycystic kidney disease (ADPKD), autosomal recessive polycystic kidney disease (ARPKD), ARPKD associated congenital hepatic fibrosis, ARPKD associated Caroli's disease, or cholangiocarcinoma in a mammal in need thereof by administering a 20-HETE synthesizing enzyme inhibitor or a 20-HETE antagonist to the mammal in an amount sufficient to prevent or treat the disease.