Wilma M Wasco from Wayland, MA, age 64

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Author
Wilma Wasco

ISBN #
0896033716

Chromosone 1 Gene And Gene Products Related To Alzheimers Disease
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US Patent:

6468791, Oct 22, 2002
Filed:

Aug 16, 1999
Appl. No.:

09/375318
Inventors:

Rudolph E. Tanzi - Canton MA
Gerard D. Schellenberg - Seattle WA
Wilma Wasco - Cambridge MA
Thomas D. Bird - Seattle WA
David J. Galas - Mercer Island WA
Assignee:

The General Hospital Corp. - Boston MA
University of Washington - Seattle WA
International Classification:

C12N 1500
US Classification:

435325, 435 691, 4353201, 536 231, 536 2431, 536 235
Abstract:

The present invention discloses nucleic acid molecules encoding AD4 gene products, expression vectors and host cells suitable for expressing such gene products. Also disclosed are methods for treating, preventing, and diagnosing Alzheimers Disease.

Genetic Alterations Related To Familial Alzheimer's Disease
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US Patent:

20010012626, Aug 9, 2001
Filed:

Feb 20, 2001
Appl. No.:

09/785474
Inventors:

Rudolph Tanzi - Hull MA, US
Wilma Wasco - Cambridge MA, US
Assignee:

The General Hospital Corporation
International Classification:

C12P021/06
C07K001/00
C07K014/00
C07K017/00
C07H021/04
US Classification:

435/069100, 435/325000, 530/350000, 536/023500
Abstract:

Isolated nucleic acid molecules are provided encoding human PS1 gene products. Mutant PS1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of the activity of the PS1 polypeptide and mutants thereof. Also provided are diagnostic methods for detecting Alzheimer's disease and therapeutic methods for treating the same.

Chromosome 1 Gene And Gene Products Related To Alzheimer's Disease
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US Patent:

20030180880, Sep 25, 2003
Filed:

Jun 24, 2002
Appl. No.:

10/180781
Inventors:

Rudolph Tanzi - Hull MA, US
Gerard Schellenberg - Seattle WA, US
Wilma Wasco - Arlington MA, US
Ephrat Levy-Lahad - Jerusalem, IL
Thomas Bird - Seattle WA, US
David Galas - Claremont CA, US
Assignee:

University of Washington - Seattle WA
International Classification:

C12P021/02
C07K014/435
C07H021/04
C12N005/08
US Classification:

435/069100, 435/320100, 435/368000, 435/325000, 530/350000, 536/023500
Abstract:

The present invention discloses nucleic acid molecules encoding AD4 gene products, expression vectors and host cells suitable for expressing such gene products. Also disclosed are methods for treating, preventing, and diagnosing Alzheimer's Disease.

Reduction Of Beta-Amyloid Levels By Treatment With The Small Molecule Differentiation-Inducing Factor
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US Patent:

20100311726, Dec 9, 2010
Filed:

Jul 16, 2008
Appl. No.:

12/669101
Inventors:

Michael Myre - Salem MA, US
Wilma Wasco - Arlington MA, US
Rudolph E. Tanzi - Hull MA, US
International Classification:

A61K 31/12
A61K 31/445
A61K 31/27
A61K 31/55
A61K 31/4355
A61K 31/13
A61K 31/498
A61P 25/00
A61P 25/28
US Classification:

514215, 514678, 514319, 514479, 514297, 514662, 514249, 514291
Abstract:

The present invention relates to novel uses for a family of small molecules, Differentiation-Inducing Factors (DIFs). It has been discovered that DIFs surprisingly can alter the metabolic processing of amyloid precursor protein (APP) and in turn reduce the level of secreted Aβ. The metabolic processing of other γ-secretase substrates normally present in cells (Notch and APLP1) is not affected when treated with DIF. The invention provides methods for reducing Aβ production in mammalian cells that express APP by administering DIF-I, DIF-2, DIF-3, a functionally equivalent analog and or any combination thereof. The invention also provides methods for treating and/or preventing Alzheimer's disease by preferentially reducing Aβ production.

Amyloid Precursor-Like Protein And Uses Thereof
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US Patent:

58919910, Apr 6, 1999
Filed:

Aug 6, 1996
Appl. No.:

8/689276
Inventors:

Wilma Wasco - Boston MA
Keith Bupp - Chalfont PA
Margaret Magendantz - Summerville MA
Rudolph Tanzi - Canton MA
Frank Solomon - Cambridge MA
Assignee:

The General Hospital Corporation - Boston MA
The Massachusetts Institute of Technology - Cambridge MA
International Classification:

A61K 3800
US Classification:

530300
Abstract:

The present invention is directed to isolated amyloid precursor-like proteins (APLPs), nucleotide sequences coding for and regulating expression of these protein, antibodies directed against these proteins, and recombinant vectors and host cells containing the genetic sequences coding for and regulating the expression of these protein sequences. The invention is also directed to isolated genomic. DNA, cDNA anti-sense RNA, and RNA containing the protein sequence. Antibodies can be used to detect an APLP in biological specimens, including, for example, fluid, serum or tissue samples. APLP1 and APLP2 are candidate genes for late onset familial Alzheimer's disease.

Genetic Alterations Related To Familial Alzheimer's Disease
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US Patent:

62485555, Jun 19, 2001
Filed:

Aug 30, 1996
Appl. No.:

8/706344
Inventors:

Rudolph Tanzi - Canton MA
Wilma Wasco - Cambridge MA
Assignee:

The General Hospital Corporation - Boston MA
International Classification:

C12N 1512
C12N 1563
C12N 1585
US Classification:

435 691
Abstract:

Isolated nucleic acid molecules are provided encoding human PS1 gene products. Mutant PS1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of the activity of the PS1 polypeptide and mutants thereof. Also provided are diagnostic methods for detecting Alzheimer's disease and therapeutic methods for treating the same.

Nucleic Acid Encoding Amyloid Precursor-Like Protein And Uses Thereof
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US Patent:

58517871, Dec 22, 1998
Filed:

Jan 21, 1993
Appl. No.:

8/007999
Inventors:

Wilma Wasco - Boston MA
Keith Bupp - Orsay, FR
Margaret Magendantz - Summerville MA
Rudolph Tanzi - Canton MA
Frank Solomon - Cambridge MA
Assignee:

The General Hospital Corporation - Boston MA
The Massachusetts Institute of Technology - Cambridge MA
International Classification:

C12N 1509
C12N 1512
C12N 506
C07H 2100
US Classification:

435 691
Abstract:

The present invention is directed to isolated amyloid precursor-like proteins (APLPs), nucleotide sequences coding for and regulating expression of these protein, antibodies directed against these proteins, and recombinant vectors and host cells containing the genetic sequences coding for and regulating the expression of these protein sequences. The invention is also directed to isolated genomic DNA, cDNA anti-sense RNA, and RNA containing the protein sequence. Antibodies can be used to detect an APLP in biological specimens, including, for example, fluid, serum or tissue samples. APLP1 and APLP2 are candidate genes for late onset familial Alzheimer's disease.

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Wilma M Wasco