The present invention relates to methods and compositions for inhibiting inflammatory processes (such as asthma) in the lungs, wherein oligonucleotides targeting IgE receptors and NfkappaB are administered via an aerosolized microsphere formulation.
Particle Formulations Of All-Trans Retinoic Acid And Transforming Growth Factor Beta For The Treatment Of Type 1 Diabetes Mellitus
- Pittsburgh PA, US Wilson S. Meng - Sewickley PA, US
Assignee:
University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA Duquesne University - Pittsburgh PA
International Classification:
A61K 31/203 A61K 9/50 A61K 38/18
Abstract:
Particle formulations are disclosed that include polymeric particles containing a small molecule drug and a high molecular weight therapeutic protein. Methods of making and using the particle formulations also are disclosed. These particle formulations are of use to treat an autoimmune disease, such as diabetes, or an inflammatory disease.