Wu A Cheng from Gilbert, AZ, age 41

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Work:

Doctor and An Orthopaedic

Alternatively Spliced Mrna Isoforms As Prognostic Indicators For Metastatic Cancer
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US Patent:

20140066319, Mar 6, 2014
Filed:

Feb 24, 2012
Appl. No.:

14/000995
Inventors:

Frank B. Gertler - Boston MA, US
Christopher Boyce Burge - Belmont MA, US
Irina M. Shapiro - Chestnut Hill MA, US
Wu Albert Cheng - Somerville MA, US
John S. Condeelis - City Island ,Bronx NY, US
Maja H. Oktay - Rye NY, US
Assignee:

Massachusetts Institute of Technology - Cambridge MA
Montefiore Medical Center - Bronx NY
Albert Einstein College of Medicine of Yeshiva University - Bronx NY
International Classification:

C12Q 1/68
US Classification:

506 7, 506 17
Abstract:

The present invention provides a method for identifying a tumor as likely to metastasize, or likely to have metastasized, comprising obtaining a sample of the tumor and quantitating alternatively spliced mRNA isoforms of a cell motility gene, a cell adhesion gene and/or an actin cytoskeletal remodeling gene in the sample, or any specified genes or the level of RNA binding proteins compared to a predetermined non-metastasizing control.

Methods Of Mutating, Modifying Or Modulating Nucleic Acid In A Cell Or Nonhuman Mammal
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US Patent:

20160186208, Jun 30, 2016
Filed:

Apr 16, 2014
Appl. No.:

14/785031
Inventors:

- Cambridge MA, US
Haoyi Wang - Cambridge MA, US
Hui Yang - Cambridge MA, US
Chikdu Shivalila - Cambridge MA, US
Wu Albert Cheng - Cambridge MA, US
International Classification:

C12N 15/85
C12N 15/90
A01K 67/027
Abstract:

The invention is directed to a method of mutating one or more target nucleic acid sequences in a stem cell or a zygote comprising introducing into the stem cell or zygote (i) ribonucleic acid (RNA) sequences that comprise a portion that is complementary to a portion of each of the target nucleic acid sequences and comprise a binding site for a CRISPR associated (Cas) protein; and a Cas nucleic acid sequence or a variant thereof that encodes a Cas protein having nuclease activity. The stem cell or zygote is maintained under conditions in which the target nucleic acid sequences are mutated in the stem cell or zygote. The invention is also directed to methods of producing a non human mammal carrying mutations and methods of modulating the expression and/or activity target nucleic acid sequences and cells or zygotes.