Xi Wang Chen

US Patent:

20120040966, Feb 16, 2012

Filed:

Dec 28, 2009

Appl. No.:

13/142678

Inventors:

Joseph A. Maddry - Birmingham AL, US
Bill Severson - Birmingham AL, US
Colleen B. Jonsson - Louisville KY, US
James W. Noah - Sterrett AL, US
Diana L. Noah - Sterrett AL, US
Xi Chen - Hoover AL, US

Assignee:

Southern Research Institute Office of Commercialization and Intellectual Prop - Birmingham AL

International Classification:

A61K 31/55
C07D 405/10
C07D 401/04
C07D 491/052
C07D 495/04
A61P 31/16
A61K 31/517
A61K 31/519
A61K 31/5377
C12Q 1/70
A61P 31/12
A61P 31/14
C07D 239/70
C07D 471/04

US Classification:

514215, 544249, 544250, 544115, 540586, 514267, 5142328, 435 5

Abstract:

The compounds provided herein are suitable for inhibiting a virus in a patient and for treating a patient suffering from a viral infection such as an influenza virus. Also provided is a method for screening of compounds for use in treating and preventing viral infections. The assay screens compounds for activity against an influenza virus by measuring the cytopathogenic effect (CPE) of the compound on influenza infected-cells using percent cell viability as the end point.

US Patent:

20220315553, Oct 6, 2022

Filed:

Jun 8, 2022

Appl. No.:

17/835551

Inventors:

- Orange Beach AL, US
Xi Chen - Hoover AL, US
Adam B. Keeton - Gardendale AL, US
Michael R. Boyd - Orange Beach AL, US

Assignee:

ADT Pharmaceuticals, LLC - Orange Beach AL

International Classification:

C07D 317/64
A61K 31/445
A61K 31/44
A61K 31/40
A61K 31/401
A61K 31/36
A61K 31/341
C07D 211/56
C07D 213/75
C07D 207/14
C07D 207/337
C07D 307/54
C07C 235/32
C07C 237/20
C07D 235/30
C07D 405/12
C07D 213/24
C07D 307/38
C07D 307/52
A61K 45/06
C07C 233/58

Abstract:

Disclosed are compounds, for example, compounds of formula I,wherein R, R, R-R, n, X, Y, Y′, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition, for example, cancer.

US Patent:

20210261572, Aug 26, 2021

Filed:

Apr 26, 2019

Appl. No.:

17/047787

Inventors:

- Orange Beach AL, US
Xi CHEN - Hoover AL, US

Assignee:

ADT PHARMACEUTICALS, LLC - Orange Beach AL

International Classification:

C07F 5/02
C07D 307/52
C07D 213/40
C07C 235/32
C07D 213/56
C07D 261/08
C07D 277/28
C07D 317/12
C07D 327/04
C07D 231/40

Abstract:

Disclosed are compounds for medical uses, for example, compounds of formula (Ia), wherein A, A, A, A, A, A, A, R, Rand E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition, for example, cancer.

US Patent:

20210069908, Mar 11, 2021

Filed:

Sep 8, 2020

Appl. No.:

17/014321

Inventors:

- Berkeley CA, US
Nikhil Mishra - Irvine CA, US
Yu Xuan Liu - Sugar Lane TX, US
Yan Duan - Berkeley CA, US
Andrew Amir Vaziri - Lutherville MD, US
Xi Chen - Berkeley CA, US

International Classification:

B25J 9/16
B25J 13/08

Abstract:

Various embodiments of the present technology generally relate to robotic devices, computer-vision systems, and artificial intelligence. More specifically, some embodiments relate to a computer-vision system for robotic devices. In some implementations, a computer-vision is coupled to a robotic arm for picking items from a bin and perturbing items in a bin. A computer-vision system, in accordance with the present technology, may use at least two two-dimensional (2D) images to generate three-dimensional (3D) information about the bin and items in the bin. A method of training artificial neural networks to generate 3D information from 2D images includes obtaining ground truth data for a scene, obtaining at least two images of the scene, and providing the ground truth data and the at least two images to the artificial neural network configured to generate a depth map from the images based on the ground truth data.

US Patent:

20200223815, Jul 16, 2020

Filed:

Mar 30, 2020

Appl. No.:

16/834267

Inventors:

- Orange Beach AL, US
Xi Chen - Hoover AL, US
Adam B. Keeton - Gardendale AL, US
Michael R. Boyd - Orange Beach AL, US

Assignee:

ADT Pharmaceuticals, LLC - Orange Beach AL

International Classification:

C07D 317/64
A61K 31/445
A61K 31/44
A61K 31/40
A61K 31/401
A61K 31/36
A61K 31/341
C07D 211/56
C07D 213/75
C07D 207/14
C07D 207/337
C07D 307/54
C07C 235/32
C07C 237/20
C07D 235/30
C07D 405/12
C07D 213/24
C07D 307/38
C07D 307/52
A61K 45/06
C07C 233/58

Abstract:

Disclosed are compounds, for example, compounds of formula I,wherein R, R, R-R, n, X, Y, Y′, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition, for example, cancer.

US Patent:

20200223816, Jul 16, 2020

Filed:

Mar 30, 2020

Appl. No.:

16/834348

Inventors:

- Orange Beach AL, US
Xi Chen - Hoover AL, US
Adam B. Keeton - Gardendale AL, US
Michael R. Boyd - Orange Beach AL, US

Assignee:

ADT Pharmaceuticals, LLC - Orange Beach AL

International Classification:

C07D 317/64
A61K 31/445
A61K 31/44
A61K 31/40
A61K 31/401
A61K 31/36
A61K 31/341
C07D 211/56
C07D 213/75
C07D 207/14
C07D 207/337
C07D 307/54
C07C 235/32
C07C 237/20
C07D 235/30
C07D 405/12
C07D 213/24
C07D 307/38
C07D 307/52
A61K 45/06
C07C 233/58

Abstract:

Disclosed are compounds, for example, compounds of formula I,wherein R, R, R-R, n, X, Y, Y′, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition, for example, cancer.

US Patent:

20200223817, Jul 16, 2020

Filed:

Apr 1, 2020

Appl. No.:

16/837757

Inventors:

- Orange Beach AL, US
Xi Chen - Hoover AL, US
Adam B. Keeton - Gardendale AL, US
Michael R. Boyd - Orange Beach AL, US

Assignee:

ADT Pharmaceuticals, LLC - Orange Beach AL

International Classification:

C07D 317/64
C07D 307/52
C07C 235/34
C07D 213/75
C07D 207/14
C07D 213/40
C07D 207/335
C07C 311/29
A61K 31/165
A61K 31/216
A61K 31/421
A61K 31/4402
A61K 31/4406
A61K 31/496
A61K 31/5375
A61K 31/5377
C07C 235/32
C07C 237/20
C07D 213/24
C07D 235/30
C07D 307/38
C07D 405/12
A61K 31/401
A61K 31/167
A61K 31/341
A61K 31/40
A61K 45/06
G01N 33/574
A61K 31/36
A61K 31/44
A61K 31/445
C07C 233/58
C07D 207/337
C07D 211/56
C07D 307/54

Abstract:

Disclosed are compounds, for example, a compound of formula I,wherein R, R, R-R, n, X, Y, Y′, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition for example, cancer, mediated by the ras gene.

US Patent:

20200095184, Mar 26, 2020

Filed:

Mar 16, 2018

Appl. No.:

16/495013

Inventors:

- Mobile AL, US
Xi Chen - Hoover AL, US
Herbert Weissbach - Boynton Beach FL, US
Shailaja Kesraju Allani - Boynton Beach FL, US

Assignee:

University of South Alabama - Mobile AL

International Classification:

C07C 59/72
A61P 9/10

Abstract:

The disclosure provides chemical compounds possessing therapeutic and/or protective properties against oxidative damage. Methods of making such therapeutic and/or protective compounds and associated compositions are also provided, as are methods for their use, which include protecting cells from oxidative damage and/or inhibiting production of ROS in a cell or subject, as well as preventing or reducing the extent of tissue damage caused by an ischemic event in a subject at elevated risk of such an event.