Xiang Liu

US Patent:

7509404, Mar 24, 2009

Filed:

Mar 5, 2001

Appl. No.:

09/800115

Inventors:

Alok Agrawal - Cambridge MA, US
Ramkumar Venketaramani - Foster City CA, US
Leslie Bruce Lowenthal - Los Gatos CA, US
Lawrence Jacobs - Redwood City CA, US
Xiang Liu - San Mateo CA, US
Shehzaad Nakhoda - Palo Alto CA, US
Zheng Zeng - Foster City CA, US
Rajiv Mishra - Foster City CA, US

Assignee:

Oracle International Corporation - Redwood Shores CA

International Classification:

G06F 15/16

US Classification:

709223, 709217, 707 10, 718101, 710 52

Abstract:

A method of servicing a request for a document over a computer network includes independently caching portions of pages called blocks. Each block includes a reference to a data source and code that is adapted to access the data source and to format the data accessed from the data source. When a request for a page is received over a computer network, one or more of the plurality of blocks defined in the script of the requested document may be retrieved from a cache memory. Any block that is not found in the cache memory is dynamically generated and a copy thereof is stored in the cache memory. The requested page may then be assembled from the page blocks retrieved from the cache memory and/or the dynamically generated page blocks.

US Patent:

20220380352, Dec 1, 2022

Filed:

May 3, 2022

Appl. No.:

17/661909

Inventors:

- Tokyo, JP
Silvia BUONAMICI - Boston, US
Thiwanka SAMARAKOON - Westwood MA, US
Sudeep PRAJAPATI - Somerville MA, US
Nathan FISHKIN - Weymouth MA, US
James PALACINO - Wellesley MA, US
Michael SEILER - Belmont MA, US
Ping ZHU - Acton MA, US
Andrew COOK - Stow MA, US
Peter SMITH - Arlington MA, US
Xiang LIU - Winchester MA, US
Shelby ELLERY - Boston MA, US
Dominic REYNOLDS - Stoneham MA, US
Lihua YU - Acton MA, US
Zhenhua WU - Belmont MA, US
Shouyong PENG - Belmont MA, US
Nicholas CALANDRA - Boston MA, US
Megan SHEEHAN - Allston MA, US
Yonghong XIAO - Belmont MA, US

International Classification:

C07D 405/12
A61P 35/00
A61K 47/68
A61K 47/60
A61K 9/127
A61K 9/51
A61K 31/365
A61K 31/496
A61K 39/00
A61K 39/395
A61K 45/06
C07D 313/00
C07D 405/06
C07K 16/24
C07K 16/28
C07K 16/30
C07K 16/32
C07K 16/40
C12Q 1/6886
G01N 33/50
G01N 33/574

Abstract:

Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

US Patent:

20230062861, Mar 2, 2023

Filed:

Nov 8, 2021

Appl. No.:

17/521666

Inventors:

- Tokyo, JP
Hyelee LEE - Billerica MA, US
Stephanos IOANNIDIS - Natick MA, US
Kiyoyuki OMOTO - Bedford MA, US
Alan ROLFE - Medford MA, US
Xiang LIU - Winchester MA, US
Megan SHEEHAN - Boston MA, US
Paul DRANSFIELD - Arlington MA, US
Andrew COOK - Stow MA, US

International Classification:

C07D 401/14
C07D 405/14
C07D 413/14
C07D 471/04
C07D 471/08
C07D 493/08
C07D 417/14
C07D 491/04
C07D 409/14
C07D 498/08
C07D 498/04
C07D 487/04
C07D 491/10
C07F 5/02

Abstract:

Disclosed herein are novel compounds of Formula (1) and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing the same, and methods of using the same.

US Patent:

20210299269, Sep 30, 2021

Filed:

May 31, 2019

Appl. No.:

17/059635

Inventors:

- TOKYO, JP
Silvia BUONAMICI - Boston MA, US
Thiwanka SAMARAKOON - Westwood MA, US
Sudeep PRAJAPATI - Somerville MA, US
Nathan FISHKIN - Weymouth MA, US
James PALACINO - Wellesley MA, US
Michael SEILER - Belmont MA, US
Ping ZHU - Acton MA, US
Andrew COOK - Stow MA, US
Peter SMITH - Arlington MA, US
Xiang LIU - Winchester MA, US
Shelby ELLERY - Boston MA, US
Dominic REYNOLDS - Stoneham MA, US
Lihua YU - Acton MA, US
Zhenhua WU - Belmont MA, US
Shouyong PENG - Tbilisi, GE
Nicholas CALANDRA - Boston MA, US
Megan SHEEHAN - Allston MA, US
Yonghong Xiao - Belmont MA, US

International Classification:

A61K 47/68
C07K 16/32
C07K 16/28
C07K 16/40
A61K 47/60
C07D 405/06
A61P 35/00
G01N 33/50
C07D 313/00
A61K 31/496
A61K 31/365
A61K 39/395
A61K 45/06
A61K 39/00
A61K 9/127
A61K 9/51
C12Q 1/6886
G01N 33/574
C07K 16/30
C07K 16/24

Abstract:

Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

US Patent:

20210163456, Jun 3, 2021

Filed:

Apr 8, 2019

Appl. No.:

17/045952

Inventors:

- Tokyo, JP
John WANG - Andover MA, US
Baudouin GERARD - Belmont MA, US
Kenzo ARAI - Ibaraki, JP
Xiang LIU - Winchester MA, US
Guo Zhu ZHENG - Lexington MA, US
Kazunobu KIRA - Ibaraki, JP
Lisa A. MARCAURELLE - Arlington MA, US
Marta NEVALAINEN - Weymouth MA, US
Ming-Hong HAO - Quincy MA, US
Morgan Welzel O'SHEA - Arlington MA, US
Parcharee TIVITMAHAISOON - Boston MA, US
Sudeep PRAJAPATI - Somerville MA, US
Nicholas C. GEARHART - Durango CO, US
Jason T. LOWE - East Bridgewater MA, US
Yoshihiko KOTAKE - Ibaraki, JP
Satoshi NAGAO - Ibaraki, JP
Regina Mikie KANADA SONOBE - Ibaraki, JP
Masayuki MIYANO - Ibaraki, JP
Norio MURAI - Ibaraki, JP
Andrew COOK - Stow MA, US
Shelby ELLERY - Boston MA, US
Atsushi ENDO - Andover MA, US
James PALACINO - Wellesley MA, US
Dominic REYNOLDS - Stoneham MA, US

Assignee:

EISAI R&D MANAGEMENT CO., LTD. - Tokyo

International Classification:

C07D 407/06
C07D 405/14
A61P 35/00
C07D 313/00
C07D 491/107
C07D 487/08
C07D 487/10
A61K 45/06
C07D 405/12
C07D 417/12
C07D 413/12

Abstract:

The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

US Patent:

20210101888, Apr 8, 2021

Filed:

Nov 30, 2020

Appl. No.:

17/247117

Inventors:

- Tokyo, JP
Silvia BUONAMICI - Boston MA, US
Thiwanka SAMARAKOON - Westwood MA, US
Sudeep PRAJAPATI - Somerville MA, US
Nathan FISHKIN - Weymouth MA, US
James PALACINO - Wellesley MA, US
Michael SEILER - Belmont MA, US
Ping ZHU - Acton MA, US
Andrew COOK - Stow MA, US
Peter SMITH - Arlington MA, US
Xiang LIU - Winchester MA, US
Shelby ELLERY - Boston MA, US
Dominic REYNOLDS - Stoneham MA, US
Lihua YU - Acton MA, US
Zhenhua WU - Belmont MA, US
Shouyong PENG - Belmont MA, US
Nicholas CALANDRA - Boston MA, US
Megan SHEEHAN - Allston MA, US
Yonghong XIAO - Belmont MA, US

International Classification:

C07D 405/12
A61P 35/00

Abstract:

Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

US Patent:

20200361915, Nov 19, 2020

Filed:

Jul 17, 2020

Appl. No.:

16/932627

Inventors:

- Tokyo, JP
John Wang - Andover MA, US
Baudouin Gerard - Belmont MA, US
Kenzo Arai - Tsukuba-shi, JP
Xiang Liu - Winchester MA, US
Guo Zhu Zheng - Lexington MA, US
Kazunobu Kira - Tsukuba-shi, JP
Parcharee Tivitmahaisoon - Boston MA, US
Sudeep Prajapati - Somerville MA, US
Nicholas C. Gearhart - Durango CO, US
Yoshihiko Kotake - Tsukuba-shi, JP
Satoshi Nagao - Tsukuba-shi, JP
Regina Mikie Kanada Sonobe - Tsukuba-shi, JP
Masayuki Miyano - Tsukuba-shi, JP
Norio Murai - Tsukuba-shi, JP
Silvia Buonamici - Boston MA, US
Lihua Yu - Acton MA, US
Eunice Sun Park - Arlington MA, US
Betty Chan - Harvard MA, US
Peter G. Smith - Arlington MA, US
Michael P. Thomas - Stoneham MA, US
Ermira Pazolli - Wayland MA, US
Kian Huat Lim - Burlington MA, US
Atsushi Endo - Andover MA, US
Arani Chanda - Malden MA, US

Assignee:

EISAI R&D MANAGEMENT CO., LTD. - Tokyo

International Classification:

C07D 405/14
C07D 405/06
A61P 35/02

Abstract:

The present disclosure provides a novel solid state form of pladienolide pyridine compounds, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.

US Patent:

20200138689, May 7, 2020

Filed:

Jun 13, 2018

Appl. No.:

16/618815

Inventors:

- Midland MI, US
- Collegeville PA, US
Yunshen Chen - Lexington MA, US
Shannon Golden - Saginaw MI, US
Jennifer Koenig - Lansdale PA, US
Lyndsay M. Leal - Spring City PA, US
Xiang Qian Liu - Collegeville PA, US
Fanwen Zeng - Audubon PA, US

International Classification:

A61K 8/81
A61K 8/37
A61K 8/41
A61Q 19/10
A61K 8/46
A61K 8/04

Abstract:

Provided are personal care compositions including (a) hydrophobic ester oil, (b) at least one of a nonionic or anionic surfactant, and (c) one or more polymers containing polymerized structural units of (i) 79 to 95.74 weight % of C-C(meth)acrylate monomers, (ii) 0.5 to 5 weight % of (meth)acrylic acid monomer, (iii) 3.75 to 14 weight % of (methoxy) poly(ethylene glycol) methacrylates, and (iv) 0.01 to 2 weight % of at least one crosslinker.