Xiao Dan Chen

US Patent:

6436928, Aug 20, 2002

Filed:

Dec 14, 2000

Appl. No.:

09/737036

Inventors:

Neng-Yang Shih - North Caldwell NJ
Gregory A. Reichard - Morris Plains NJ
Sunil Paliwal - Scotch Plains NJ
David J. Blythin - North Caldwell NJ
John J. Piwinski - Clinton Township NJ
Dong Xiao - Scotch Plains NJ
Xiao Chen - Edison NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 314166

US Classification:

5142278, 514396, 514399, 514400, 5483165, 5483235

Abstract:

A compound represented by the structural formula or a pharmaceutically acceptable salt thereof, wherein Ar and Ar are optionally substituted heteroaryl or optionally substituted phenyl; X is âOâ, âSO â, âNR â, âNCOR â or âNR SO R ; âis X is âOâ, âSâ or optionally substituted nitrogen; Y is O, S or NR ; Y is H, alkyl, âNR R , âSCH , R -aryl(CH ) â, R -heteroaryl-(CH ) â, â(CH ) -heterocycloalkyl, -alkyl-NHâC(O)O-alkyl or âNHC(O)R ; R , R , R and R are H, alkyl, OH-alkyl, cycloalkyl, âCHF , âCH F or âCF ; or R and R form an alkylene ring; or R and R together are O; R is H, alkyl, âOR or âSR ; and the remaining variables are as defined in the specification, is disclosed, as well as a pharmaceutical compositions comprising said compound, methods of using said compound as a neurokinin antagonist, and the combination of said compounds with a selective serotonin reuptake inhibitor.

US Patent:

6635630, Oct 21, 2003

Filed:

Jun 6, 2002

Appl. No.:

10/163663

Inventors:

Neng-Yang Shih - North Caldwell NJ
Gregory A. Reichard - Morris Plains NJ
Sunil Paliwal - Scotch Plains NJ
David J. Blythin - North Caldwell NJ
John J. Piwinski - Clinton Township NJ
Dong Xiao - Scotch Plains NJ
Xiao Chen - Edison NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31330

US Classification:

514183, 514396, 514397, 514398, 514400, 5483235, 5483215, 5483251, 5483255, 5483265, 548134

Abstract:

Compound represented by the structural formula or a pharmaceutically acceptable salt thereof, wherein Ar and Ar are optionally substituted heteroaryl or optionally substituted phenyl; X is âOâ, âSâ, âSOâ, âSO â, âNR â, âNCOR â or âNR SO R ; âis selected from the group consisting of X is âOâ, âSâ or âNR â; Y is O, S or NR ; Y is H, C -C alkyl, âNR R , âSCH , R -aryl(CH ) â, R -heteroaryl-(CH ) â, â(CH ) âheterocycloalkyl, â(C -C )alkyl-NHâC(O)O(C -C )alkyl or âNHC(O)R ; R is H or â(CH ) âG, wherein n is 0-5, G is H, âCF , âCHF , âCH F, âOH, âOâ(C -C alkyl), âSO R , âOâ(C -C cycloalkyl), âNR R , âSO NR R , âNR SO R , âNR COR , âNR (CONR R ), âCONR R , âCOOR , C -C cycloalkyl, R -aryl, R -heteroaryl, and provided when n =0, G is not H; R , R , R and R are H, alkyl, cycloalkyl, âCHF , âCH F or âCF ; or R and R , together with the carbon to which they are attached, form an alkylene ring; or R and R together are O; R is R or âOH; and the remaining variables are as defined in the specification, methods of treating diseases susceptible to treatment with neurokinin antagonists with said compounds, and pharmaceutical compositions comprising said compounds are disclosed. Also disclosed are pharmaceutical compositions comprising an effective amount of a compound of claim 1, at least one pharmaceutically acceptable carrier, and in combination with an effective amount of a selective serotonin reuptake inhibitor.

US Patent:

7160856, Jan 9, 2007

Filed:

Jul 25, 2002

Appl. No.:

10/205021

Inventors:

Samuel J. Danishefsky - Englewood NJ, US
Dalibor Sames - New York NY, US
Samuel Hintermann - Basel, CH
Xiao Tao Chen - Newark DE, US
Jacob B. Schwarz - Ann Arbor MI, US
Peter Glunz - Wilmington DE, US
Philip O. Livingston - New York NY, US
Scott Kuduk - Harleyville PA, US
Lawrence Williams - New York NY, US

Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY

International Classification:

A61K 38/14
A61K 39/385
C07K 9/00

US Classification:

514 8, 4241851, 4241941, 4242771, 530322

Abstract:

The present invention provides novel α-O-linked glycoconjugates such as α-O-linked glycopeptides, as well convergent methods for synthesis thereof. The general preparative approach is exemplified by the synthesis of the mucin motif commonly found on epithelial tumor cell surfaces. The present invention further provides compositions and methods of treating cancer using the α-O-linked glycoconjugates.

US Patent:

7956189, Jun 7, 2011

Filed:

Aug 10, 2007

Appl. No.:

11/891351

Inventors:

Xiaoming Chen - Westfield NJ, US
Xiao Chen - Edison NJ, US
Jianguo Yin - Plainsboro NJ, US
Xiaoyong Fu - Edison NJ, US
David J. Blythin - North Caldwell NJ, US
Rongze Kuang - Green Brook NJ, US
Scott Trzaska - Raritan NJ, US
Chee-Wah Tang - Singapore, SG
Vincenzo Liotta - Glen Ridge NJ, US
Zaher Shabani - Budd Lake NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D 215/38

US Classification:

546167

Abstract:

Disclosed are maleate, tosylate, fumarate, and oxalate salts of the compound 5-(1(S)-Amino-2-Hydroxyethyl)-N-[(2,4-Difluorophenyl)-Methyl]-2-[8-Methoxy-2-(Trifluoromethyl)-5-Quinoline]-4-Oxazolecarboxamide, represented by Formula I, and methods of preparing the same.

US Patent:

20040102607, May 27, 2004

Filed:

Jun 19, 2003

Appl. No.:

10/600012

Inventors:

Samuel Danishefsky - Englewood NJ, US
Dalibor Sames - New York NY, US
Samuel Hintermann - Basel, CH
Xiao Chen - Newark DE, US
Jacob Schwarz - Ann Arbor MI, US
Peter Glunz - Wilmington DE, US
Philip Livingston - New York NY, US
Scott Kuduk - Harleyville PA, US
Kenneth Lloyd - New York NY, US
Lawrence Williams - New York NY, US
Valery Kudryashov - Brooklyn NY, US

International Classification:

C07K009/00
A61K038/14

US Classification:

530/322000, 514/008000

Abstract:

The present invention provides novel -O-linked glycoconjugates such as -O-linked glycopeptides, as well as convergent methods for the synthesis thereof. The general preparative approach is exemplified by the synthesis of the mucin motif commonly found on epithelial tumor cell surfaces. The present invention further provides compositions and methods of treating cancer using the -O-linked glycoconjugates.

US Patent:

57983593, Aug 25, 1998

Filed:

May 25, 1995

Appl. No.:

8/451113

Inventors:

Neng-Yang Shih - North Caldwell NJ
John Piwinski - Clinton Township NJ
Xiao Chen - Edison NJ
David J. Blythin - North Caldwell NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31495
A61K 31395
C07D40100
C07D40300

US Classification:

514255

Abstract:

The invention relates to compounds of the formulas ##STR1## wherein Z, R. sub. c, y, x, l. sub. 1, l. sub. 2, l. sub. 3, u, R. sub. 4, R. sub. c', n, R. sub. 1, R. sub. 2, and R. sub. 3, are as described herein. These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.

US Patent:

57191565, Feb 17, 1998

Filed:

May 2, 1995

Appl. No.:

8/432739

Inventors:

Neng-Yang Shih - North Caldwell NJ
John Piwinski - Clinton Township NJ
Xiao Chen - Edison NJ
David J. Blythin - North Caldwell NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31495
A61K 3155
C07D24308
C07D40300

US Classification:

514255

Abstract:

The invention relates to compounds of the formulas ##STR1## wherein Z, R. sub. c, y, x, l. sub. 1, l. sub. 2, l. sub. 3, u, R. sub. 4,R. sub. c', n, R. sub. 1, R. sub. 2, and R. sub. 3, are as described herein. These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.

US Patent:

58694889, Feb 9, 1999

Filed:

Aug 29, 1996

Appl. No.:

8/703154

Inventors:

Neng-Yang Shih - North Caldwell NJ
David J. Blythin - North Caldwell NJ
Xiao Chen - Edison NJ
John J. Piwinski - Clinton Township NJ
Kevin D. McCormick - Edison NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31495
C07D40112
C07D40312

US Classification:

514252

Abstract:

The invention relates to compounds of the formula ##STR1## wherein Z, R. sub. c, y, m, u, Ar. sub. 2, n, X, R. sub. c', I and Ar. sub. 2 are as described herein. These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.

Address:

4118 71 St, Woodside, NY 11377

VIN:

5J8TB1H57AA008722

Make:

ACURA

Model:

RDX

Year:

2010