Xiao Song Chen

US Patent:

6436928, Aug 20, 2002

Filed:

Dec 14, 2000

Appl. No.:

09/737036

Inventors:

Neng-Yang Shih - North Caldwell NJ
Gregory A. Reichard - Morris Plains NJ
Sunil Paliwal - Scotch Plains NJ
David J. Blythin - North Caldwell NJ
John J. Piwinski - Clinton Township NJ
Dong Xiao - Scotch Plains NJ
Xiao Chen - Edison NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 314166

US Classification:

5142278, 514396, 514399, 514400, 5483165, 5483235

Abstract:

A compound represented by the structural formula or a pharmaceutically acceptable salt thereof, wherein Ar and Ar are optionally substituted heteroaryl or optionally substituted phenyl; X is âOâ, âSO â, âNR â, âNCOR â or âNR SO R ; âis X is âOâ, âSâ or optionally substituted nitrogen; Y is O, S or NR ; Y is H, alkyl, âNR R , âSCH , R -aryl(CH ) â, R -heteroaryl-(CH ) â, â(CH ) -heterocycloalkyl, -alkyl-NHâC(O)O-alkyl or âNHC(O)R ; R , R , R and R are H, alkyl, OH-alkyl, cycloalkyl, âCHF , âCH F or âCF ; or R and R form an alkylene ring; or R and R together are O; R is H, alkyl, âOR or âSR ; and the remaining variables are as defined in the specification, is disclosed, as well as a pharmaceutical compositions comprising said compound, methods of using said compound as a neurokinin antagonist, and the combination of said compounds with a selective serotonin reuptake inhibitor.

US Patent:

6627841, Sep 30, 2003

Filed:

May 9, 2001

Appl. No.:

09/851853

Inventors:

Xiao Chen - Peoria IL
Yi Dong - Peoria IL
Edward T. Martin - Decatur IL
Zhishang Yang - Dunlap IL
Wayne Tanner - Chicago IL

Assignee:

Caterpillar Inc. - Peoria IL

International Classification:

B23K 910

US Classification:

219110, 219109, 219119, 703 1, 703 2, 703 6

Abstract:

A method for designing a weld fixture. The method includes modeling a set of distortions produced by applied mechanical forces on a material to be welded, modeling a set of distortions produced by applied thermal forces on the material to be welded, determining a set of reaction forces at a series of locations on a simulated weld fixture as a function of the modeled distortions, and designing a weld fixture as a function of the set of reaction forces.

US Patent:

6635630, Oct 21, 2003

Filed:

Jun 6, 2002

Appl. No.:

10/163663

Inventors:

Neng-Yang Shih - North Caldwell NJ
Gregory A. Reichard - Morris Plains NJ
Sunil Paliwal - Scotch Plains NJ
David J. Blythin - North Caldwell NJ
John J. Piwinski - Clinton Township NJ
Dong Xiao - Scotch Plains NJ
Xiao Chen - Edison NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31330

US Classification:

514183, 514396, 514397, 514398, 514400, 5483235, 5483215, 5483251, 5483255, 5483265, 548134

Abstract:

Compound represented by the structural formula or a pharmaceutically acceptable salt thereof, wherein Ar and Ar are optionally substituted heteroaryl or optionally substituted phenyl; X is âOâ, âSâ, âSOâ, âSO â, âNR â, âNCOR â or âNR SO R ; âis selected from the group consisting of X is âOâ, âSâ or âNR â; Y is O, S or NR ; Y is H, C -C alkyl, âNR R , âSCH , R -aryl(CH ) â, R -heteroaryl-(CH ) â, â(CH ) âheterocycloalkyl, â(C -C )alkyl-NHâC(O)O(C -C )alkyl or âNHC(O)R ; R is H or â(CH ) âG, wherein n is 0-5, G is H, âCF , âCHF , âCH F, âOH, âOâ(C -C alkyl), âSO R , âOâ(C -C cycloalkyl), âNR R , âSO NR R , âNR SO R , âNR COR , âNR (CONR R ), âCONR R , âCOOR , C -C cycloalkyl, R -aryl, R -heteroaryl, and provided when n =0, G is not H; R , R , R and R are H, alkyl, cycloalkyl, âCHF , âCH F or âCF ; or R and R , together with the carbon to which they are attached, form an alkylene ring; or R and R together are O; R is R or âOH; and the remaining variables are as defined in the specification, methods of treating diseases susceptible to treatment with neurokinin antagonists with said compounds, and pharmaceutical compositions comprising said compounds are disclosed. Also disclosed are pharmaceutical compositions comprising an effective amount of a compound of claim 1, at least one pharmaceutically acceptable carrier, and in combination with an effective amount of a selective serotonin reuptake inhibitor.

US Patent:

6789051, Sep 7, 2004

Filed:

Sep 21, 2000

Appl. No.:

09/667077

Inventors:

Xiao Chen - Peoria IL
Yi Dong - Peoria IL
Ashok Nanjundan - Savoy IL

Assignee:

Caterpillar Inc - Peoria IL

International Classification:

G06F 1710

US Classification:

703 2, 703 7, 706915, 2191171

Abstract:

A method and apparatus for providing a simulation of a welding process using integrated models which are interconnected by an interconnection tool to determine stresses and distortions of a material being welded. The method and apparatus includes determining a model of a geometry of a set of materials to be welded, defining a set of coordinates of elements and nodes of the geometry model for a finite element analysis mesh, delivering the finite element analysis mesh coordinates to a thermal analysis model, the thermal analysis model including an analytical solution model and a finite element analysis model, and determining a thermal analysis of the welding process, the thermal analysis responsively providing a thermal history of the welding process. The method and apparatus further includes delivering the thermal history of the welding process to a structural analysis model, and providing a structural analysis of the welding process as a function of the thermal history.

US Patent:

7082338, Jul 25, 2006

Filed:

Jul 14, 2000

Appl. No.:

09/616457

Inventors:

Xiao Chen - Peoria IL, US
Yi Dong - Peoria IL, US
Tarsem S. Jutla - Peoria IL, US
Ashok Nanjundan - Savoy IL, US

Assignee:

Caterpillar Inc. - Peoria IL

International Classification:

G05B 13/02

US Classification:

700 31, 703 1, 703 6

Abstract:

A method for providing a process model for a material in a manufacturing process. The method includes the steps of receiving stress and distortion information of the material from a previous manufacturing process, determining updated stress and distortion information of the material from a process model for the present manufacturing process, the updated stress and distortion information being a function of the stresses and distortions caused by the present manufacturing process and the stresses and distortions from the previous manufacturing process, and providing the updated stress and distortion information of the material to a subsequent manufacturing process.

US Patent:

7354922, Apr 8, 2008

Filed:

Dec 1, 2005

Appl. No.:

11/291363

Inventors:

Dong Xiao - Warren NJ, US
Anandan Palani - Bridgewater NJ, US
Cheng Wang - Summit NJ, US
Xianhai Huang - Warren NJ, US
Sapna S. Shah - Jamesburg NJ, US
Ashwin U. Rao - Avenel NJ, US
Xiao Chen - Edison NJ, US
Sunil Paliwal - Monroe Township NJ, US
Neng-Yang Shih - Warren NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A01N 43/58
A01N 43/60
C07D 245/00
C07D 241/36
C07D 471/00

US Classification:

514249, 540460, 544349

Abstract:

A compound having the general structure shown in Formula (I):.

US Patent:

7511062, Mar 31, 2009

Filed:

May 16, 2005

Appl. No.:

11/130359

Inventors:

Rongze Kuang - Green Brook NJ, US
David Blythin - North Caldwell NJ, US
Neng-Yang Shih - Warren NJ, US
Xiao Chen - Edison NJ, US
Jianhua Cao - Edison NJ, US
Danlin Gu - Kirkland WA, US
Ying Huang - Berkeley Heights NJ, US
John H. Schwerdt - Lake Hiawatha NJ, US
Pauline C. Ting - New Providence NJ, US
Li Xiao - Cranbury NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D 215/38
A61K 31/44

US Classification:

514312, 514314, 546153, 546159

Abstract:

The invention claims compounds of the formula.

US Patent:

7723342, May 25, 2010

Filed:

May 11, 2006

Appl. No.:

11/432133

Inventors:

Anandan Palani - Bridgewater NJ, US
Jing Su - Scotch Plains NJ, US
Dong Xiao - Warren NJ, US
Xianhai Huang - Warren NJ, US
Ashwin U. Rao - Avenel NJ, US
Xiao Chen - Edison NJ, US
Haiqun Tang - Belle Mead NJ, US
Jun Qin - Edison NJ, US
Ying Huang - Berkeley Heights NJ, US
Robert G. Aslanian - Rockaway NJ, US
Brian A. McKittrick - New Vernon NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D 491/052
A61K 31/519
A61P 35/00
A61P 29/00
A61P 3/10
A61P 9/00
A61P 11/00

US Classification:

5142601, 544278

Abstract:

A compound having the general structure of Formula (I):.