The present application describes novel spiro-cyclic -amino acid derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-13 membered carbocycle or heterocycle, ring C forms a 3-11 membered spiro-carbocycle or spiro-heterocycleon ring B, and the other variables are defined in the present specification, which are useful as as matrix metalloproteinases (MMP), TNF- converting enzyme (TACE), and/or aggrecanase inhibitors.
Spiro-Cyclic Β-Amino Acid Derivatives As Inhibitors Of Matrix Metalloproteases And Tnf-Α Converting Enzyme (Tace)
The present application describes novel spiro-cyclic β-amino acid derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-13 membered carbocycle or heterocycle, ring C forms a 3-11 membered spiro-carbocycle or spiro-heterocycleon ring B, and the other variables are defined in the present specification, which are useful as as matrix metalloproteinases (MMP), TNF-α converting enzyme (TACE), and/or aggrecanase inhibitors.
Beta-Arrestin Effectors And Compositions And Methods Of Use Thereof
Dennis Yamashita - Wayne PA, US Xiao Tao Chen - Furlong PA, US
Assignee:
Trevena, Inc. - King of Prussia PA
International Classification:
C07K 7/06
US Classification:
514 37, 530328, 514 217, 514 164
Abstract:
This application describes compounds acting as, for example, β-arrestin effectors and uses thereof, in, for example, the treatment of chronic and acute cardiovascular diseases.
1996 to 2000 Bankruptcy Assistant/Assistant System Manager/ChapterCatholic Charities Elderly Services
1995 to 1995 SecretaryChinese Language School
1990 to 1995 TeacherUniversity of Guangzhou Guangzhou, CN 1988 to 1990 Lecturer of ChemistryInsturctor of Chemistry/College of Education, China
1982 to 1988
Education:
University of Hawaii Community Colleges 2000 Analysis/DesignThe Board of Education 1994 to 1995 Certificate of Data in MajoringNan Normal University 1988 Certificate of Lecturer in ChemistryShan University 1986 to 1987 Master's in MajoringNan Normal University 1984 Physical ChemistryThe South China Institute of Technology 1978 to 1982 Bachelor's in Physical Chemistry
Hong Kong people should have a world view, and not only focus on one citys arguments. Its not easy for the U.S. to create a disturbance in China, but its super easy to rock the boat through Hong Kong, Xiao Chen wrote.