Xiao Fang Li

US Patent:

20030124555, Jul 3, 2003

Filed:

May 21, 2002

Appl. No.:

10/151690

Inventors:

Michael Brasch - Gaithersburg MD, US
David Cheo - Kensington MD, US
Xiao Li - Germantown MD, US
Dominic Esposito - Columbia MD, US
Devon Byrd - Waynesville NC, US

Assignee:

Invitrogen Corporation

International Classification:

C12Q001/68
C12P019/34
C12N015/85

US Classification:

435/006000, 435/091100, 435/455000

Abstract:

The present invention relates generally to recombinant genetic technology. More particularly, the present invention relates to compositions and methods for use in selection and isolation of nucleic acid molecules. The invention further relates to methods for the preparation of individual nucleic acid molecules and populations of nucleic acid molecules, as well as nucleic acid molecules produced by these methods. The invention also relates to screening and/or selection methods for identifying and/or isolating nucleic acid molecules which have one or more common features (e.g., characteristics, activities, etc) and populations of nucleic acid molecules which share one or more features.

US Patent:

20060035272, Feb 16, 2006

Filed:

Oct 18, 2005

Appl. No.:

11/251821

Inventors:

Michael Brasch - Gaithersburg MD, US
David Cheo - Kensington MD, US
Xiao Li - Germantown MD, US
Dominic Esposito - Columbia MD, US
Devon Byrd - Fredericksburg VA, US

Assignee:

Invitrogen Corporation - Carlsbad CA

International Classification:

C12Q 1/68
C12N 15/63
C40B 40/08

US Classification:

435006000, 435455000

Abstract:

The present invention relates generally to recombinant genetic technology. More particularly, the present invention relates to compositions and methods for use in selection and isolation of nucleic acid molecules. The invention further relates to methods for the preparation of individual nucleic acid molecules and populations of nucleic acid molecules, as well as nucleic acid molecules produced by these methods. The invention also relates to screening and/or selection methods for identifying and/or isolating nucleic acid molecules which have one or more common features (e.g., characteristics, activities, etc) and populations of nucleic acid molecules which share one or more features.

US Patent:

20070224645, Sep 27, 2007

Filed:

Feb 23, 2007

Appl. No.:

11/709835

Inventors:

Jianming Lu - Gaithersburg MD, US
Xiao Li - Germantown MD, US

International Classification:

G01N 33/53
C12N 5/06
C12N 5/08

US Classification:

435007100, 435325000, 435348000, 435369000, 435254200, 435455000

Abstract:

The present invention relates to improved cell-based assays for the in vivo assessment of phosphodiesterase (PDE) activity using cyclic nucleotide-gated channels as cyclic nucleotide sensors, and for the assessment of the effect of PDE modulating compounds.

US Patent:

20100267128, Oct 21, 2010

Filed:

May 14, 2008

Appl. No.:

12/152606

Inventors:

Michael A. Brasch - Gaithersburg MD, US
David Cheo - Kensington MD, US
Xiao Li - Germantown MD, US
Dominic Esposito - Columbia MD, US

Assignee:

INVITROGEN CORPORATION - Carlsbad CA

International Classification:

C07H 21/04
C12N 1/21
C12N 5/10

US Classification:

435325, 536 231, 4352523

Abstract:

The present invention relates generally to recombinant genetic technology. More particularly, the present invention relates to compositions and methods for use in selection and isolation of nucleic acid molecules. The invention further relates to methods for the preparation of individual nucleic acid molecules and populations of nucleic acid molecules, as well as nucleic acid molecules produced by these methods. The invention also relates to screening and/or selection methods for identifying and/or isolating nucleic acid molecules which have one or more common features (e.g., characteristics, activities, etc) and populations of nucleic acid molecules which share one or more features.

US Patent:

20110086374, Apr 14, 2011

Filed:

Oct 8, 2010

Appl. No.:

12/900759

Inventors:

Jianming Lu - North Potomac MD, US
Xiao Li - Germantown MD, US

International Classification:

C12Q 1/44
C12N 9/16

US Classification:

435 19, 435196

Abstract:

The present invention relates to improved cell-based assays for the in vivo assessment of phosphodiesterase (PDE) activity using cyclic nucleotide-gated channels as cyclic nucleotide sensors, and for the assessment of the effect of PDE modulating compounds.

US Patent:

20110306098, Dec 15, 2011

Filed:

May 5, 2011

Appl. No.:

13/101882

Inventors:

Michael A. Brasch - Gaithersburg MD, US
David Cheo - Kensington MD, US
Xiao Li - Germantown MD, US
Dominic Esposito - Columbia MD, US
Devon R.N. Byrd - Fredericksburg VA, US

Assignee:

Invitrogen Corporation - Carlsbad CA

International Classification:

C12N 15/66
C12N 15/11
C12N 1/21
C12N 5/10
C12N 9/90
C12N 9/12
C12N 9/16
C07H 21/00
C12N 9/24
C12P 19/34
C12N 9/00

US Classification:

435 9141, 435 9152, 536 231, 4352523, 435325, 435183, 435194, 435196, 536 2433, 435200, 435233

Abstract:

The present invention relates generally to recombinant genetic technology. More particularly, the present invention relates to compositions and methods for use in selection and isolation of nucleic acid molecules. The invention further relates to methods for the preparation of individual nucleic acid molecules and populations of nucleic acid molecules, as well as nucleic acid molecules produced by these methods. The invention also relates to screening and/or selection methods for identifying and/or isolating nucleic acid molecules which have one or more common features (e.g., characteristics, activities, etc) and populations of nucleic acid molecules which share one or more features.

US Patent:

20210147834, May 20, 2021

Filed:

Nov 16, 2020

Appl. No.:

17/099093

Inventors:

Xiao Bing WANG - Sparks Glencoe MD, US
Xiao Fei LI - Sparks Glencoe MD, US

International Classification:

C12N 15/10
C12Q 1/6853

Abstract:

One embodiment provides methods to identify known and unknown gene fusions by creating a cDNA circle and analyzing the circle cDNA by amplification or sequencing. The circle cDNA is created in two approaches: 1) reverse transcribe a target RNA to cDNA, ligate the 3′end of the cDNA to its 5′ end to form a circle cDNA, or 2). ligate the 3′ end of target RNA to its 5′ end to form a circle RNA, reverse transcribe the RNA to a cDNA, and ligate the cDNA to form a circle cDNA. The circle cDNA is amplified using a primer designed from a known sequence of a wild type target gene by rolling circle amplification or PCR methods. The known or unknown fusion gene sequences in the circle cDNA are amplified and identified by sequencing analysis.

US Patent:

20190205302, Jul 4, 2019

Filed:

Mar 6, 2019

Appl. No.:

16/294514

Inventors:

- Menlo Park CA, US
Michael Benjamin Cohen - Cambridge MA, US
Maxime Boucher - Mountain View CA, US
Alisson Gusatti Azzolini - San Francisco CA, US
Xiao Li - Sunnyvale CA, US
Lars Eilstrup Rasmussen - London, GB

International Classification:

G06F 16/2453
G06F 16/2457
G06F 16/903
G06F 16/951

Abstract:

In particular embodiments, a method includes receiving, from a client system of a first user, a structured query comprising references to one or more objects associated with the online social network, identifying a set of target objects corresponding to the structured query, wherein each target object in the set is an object that is connected within the online social network to at least one of the objects referenced in the structured query, filtering the set of target objects based on a privacy setting of each of the connections to the target object, and generating search results comprising references to each target object from the post-filtered set that is connected to the first user within the online social network by a series of connections that have a visibility that is visible to the first user.