Xiaohui Sherry Lin

US Patent:

20100093768, Apr 15, 2010

Filed:

Dec 21, 2007

Appl. No.:

12/521109

Inventors:

William G. Nelson - Towson MD, US
Srinivasan Yegnasubramanian - Baltimore MD, US
Xiaohui Lin - Redlands CA, US
Traci J. Speed - Baltimore MD, US
Zachery Reichert - Baltimore MD, US

International Classification:

A61K 31/52
C12Q 1/68
A61K 31/4402
A61K 31/517
A61K 31/4164
A61K 31/341
A61K 31/40
A61K 31/415
A61K 31/4155
A61P 35/00
A61P 7/00

US Classification:

5142632, 435 6, 514333, 514342, 51426631, 514393, 514470, 514414, 514361, 514403

Abstract:

The present invention provides methods for discovering agents that are effective in reversing epigenetic silencing by inhibiting the interaction of methyl-binding (MBD) proteins with methylated genomic DNA. Also provided are methods for reactivating silenced genes having CpG island hypermethylation along with methods for treatment and prevention of diseases, such as cancer and sickle cell anemia, by administering an agent that modulates methyl-binding domain (MBD) protein-mediated transcriptional repression, thereby increasing gene transcription to prevent or treat disease. Additionally, compounds identified by the present invention useful for treatment and prevention of diseases, such as cancer and sickle cell anemia, are provided.

US Patent:

20150252438, Sep 10, 2015

Filed:

May 8, 2015

Appl. No.:

14/708045

Inventors:

- Baltimore MD, US
Srinivasan Yegnasubramanian - Baltimore MD, US
Xiaohui Lin - Redlands CA, US
Traci J. Speed - Baltimore MD, US
Zachery Reichert - Baltimore MD, US

International Classification:

C12Q 1/68
A61K 31/4439
A61K 31/4188
A61K 31/517
A61K 31/433
A61K 31/381
A61K 31/136
A61K 31/4245
A61K 31/519
A61K 31/444
A61K 31/404

Abstract:

The present invention provides methods for discovering agents that are effective in reversing epigenetic silencing by inhibiting the interaction of methyl-binding (MBD) proteins with methylated genomic DNA. Also provided are methods for reactivating silenced genes having CpG island hypermethylation along with methods for treatment and prevention of diseases, such as cancer and sickle cell anemia, by administering an agent that modulates methyl-binding domain (MBD) protein-mediated transcriptional repression, thereby increasing gene transcription to prevent or treat disease. Additionally, compounds identified by the present invention useful for treatment and prevention of diseases, such as cancer and sickle cell anemia, are provided.