Xiaoqing Li

US Patent:

20210252151, Aug 19, 2021

Filed:

Jun 14, 2019

Appl. No.:

17/251977

Inventors:

- Austin TX, US
Xiaoqing LI - Richardson TX, US
Xiuying LI - Plano TX, US
Shashank SIRSI - Dallas TX, US
Heather HAYENGA - Dallas TX, US
Edward PAN - Dallas TX, US
Robert BACHOO - Dallas TX, US

Assignee:

BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM - Austin TX

International Classification:

A61K 41/00
A61N 5/06
A61K 45/06
A61K 51/10
A61K 49/00
A61K 47/68

Abstract:

The blood-brain barrier (BBB) excludes most drugs and poses a significant challenge to treat brain diseases. Current methods for BBB opening yield modest outcomes in clinical applications due to safety and toxicity. This disclosure relates to methods of optically opening the BBB by laser excitation of tight-junction targeted nanoparticles to induce BBB transient opening. The excitation of plasmonic nanoparticles produces localized effects such as nanoscale heating and photomechanical force leading to BBB transiently opening to allow macromolecules across it. The safe and predictable platform for brain drug delivery will improve therapies for brain disease such as cancers, infections and neurologic disorders.

US Patent:

20170210920, Jul 27, 2017

Filed:

Jul 28, 2015

Appl. No.:

15/327723

Inventors:

- Wilmington DE, US
Xiaoqing Li - Newark NJ, US

International Classification:

C09D 11/102
C09D 11/322
C09D 11/033

Abstract:

The present disclosure provides aqueous ink-jet inks having improved stability containing an aqueous vehicle, a colorant, and an amphoteric polyurethane as a binder. The amphoteric polyurethane contains a plurality of tertiary amine groups derived from an amine-containing monomer, and a plurality of anionic acid groups.