Xiaoyue Zhu

US Patent:

7704728, Apr 27, 2010

Filed:

Jul 18, 2002

Appl. No.:

10/198477

Inventors:

Shuichi Takayama - Ann Arbor MI, US
Joseph Chang - Ann Arbor MI, US
Dongeun Huh - Stanford CA, US
Xiaoyue Zhu - Ann Arbor MI, US
Brenda Cho - Ann Arbor MI, US
Gary D. Smith - Ann Arbor MI, US

Assignee:

The University of Michigan - Ann Arbor MI

International Classification:

C12M 1/36

US Classification:

4352865, 4352864, 436 52, 137 1, 137 8, 13724623

Abstract:

A microfluidic system employs a microchannel and a gravity driven pump comprising horizontally oriented fluid supply reservoirs which supplies fluid to the microchannel at a substantially constant rate. The device is useful for numerous microfluidic applications, for example in the culture and/or treatment of biological systems under constant flow-induced stress, cell-size sorting, motile sperm sorting, or embryo culture.

US Patent:

7745211, Jun 29, 2010

Filed:

Mar 10, 2004

Appl. No.:

10/548692

Inventors:

Shuichi Takayama - Ann Arbor MI, US
Xiaoyue Zhu - Ann Arbor MI, US
Wei Gu - Ann Arbor MI, US
Gary Daniel Smith - Ann Arbor MI, US
Yunseok Heo - Ann Arbor MI, US
Brenda S. Cho - Ann Arbor MI, US
Nobuyuki Futai - Ann Arbor MI, US

Assignee:

The Regents of the University of Michigan - Ann Arbor MI

International Classification:

C12M 1/00
C12M 1/22
C12M 3/00

US Classification:

4353051, 4352841, 4352873, 4352878, 4352882, 4352883, 4352885, 4352931, 4353052, 4353053, 4353071

Abstract:

Microfluidic devices having active features such as valves, peristaltic pumps, and mixing portions are fabricated to have a thin elastomeric membrane over the active features. The active features are activated by a tactile actuator external to the membrane, for example, a commercial Braille display. The display may be computer controlled, for example by simple text editor software, to activate individual Braille protrusions or a plurality of protrusions to actuate the active portions of the microfluidic device. Integral devices can incorporate the tactile actuators in a single device, but still external to the membrane.

US Patent:

8313941, Nov 20, 2012

Filed:

May 20, 2010

Appl. No.:

12/783650

Inventors:

Shuichi Takayama - Ann Arbor MI, US
Xiaoyue Zhu - Ann Arbor MI, US
Wei Gu - Ann Arbor MI, US
Gary Daniel Smith - Ann Arbor MI, US
Yunseok Heo - Ann Arbor MI, US
Brenda S. Cho - Ann Arbor MI, US
Nobuyuki Futai - Ann Arbor MI, US

Assignee:

The Regents of The University of Michigan - Ann Arbor MI

International Classification:

C12M 1/00
C12M 1/22
C12M 3/00

US Classification:

4352865, 4353051, 4352841, 4352873, 4352878, 4352882, 4352931, 4353052, 4353053, 4353071, 4352883, 4352885

Abstract:

Microfluidic devices having active features such as valves, peristaltic pumps, and mixing portions are fabricated to have a thin elastomeric membrane over the active features. The active features are activated by a tactile actuator external to the membrane, for example, a commercial Braille display. The display may be computer controlled, for example by simple text editor software, to activate individual Braille protrusions or a plurality of protrusions to actuate the active portions of the microfluidic device. Integral devices can incorporate the tactile actuators in a single device, but still external to the membrane.

US Patent:

20040063199, Apr 1, 2004

Filed:

Jun 24, 2003

Appl. No.:

10/602910

Inventors:

Shuichi Takayama - Ann Arbor MI, US
Xiaoyue Zhu - Ann Arbor MI, US
Joong Bahng - Ann Arbor MI, US
Elizabeth Liu - Ann Arbor MI, US
Jeongsup Shim - Ann Arbor MI, US

International Classification:

C12M001/34
B05D003/00

US Classification:

435/287200, 427/002110

Abstract:

Nanopatterned devices are easily fabricated, over large surface areas when desired, by forming a multilayer article of deformable substrate, brittle layer, and coating layer, and deforming the multilayer film such that a plurality of cracks are formed therein. The cracks have different physicochemical properties than the non-cracked coating layer, and advantageously serve as attachment points for culturing microorganisms.

US Patent:

20100247384, Sep 30, 2010

Filed:

Oct 17, 2006

Appl. No.:

11/582259

Inventors:

Shuichi Takayama - Ann Arbor MI, US
Lourdes Marcella Cabrera - Ann Arbor MI, US
Nobuyuki Futai - Ann Arbor MI, US
Yun Seok Heo - Ann Arbor MI, US
Gary Daniel Smith - Ann Arbor MI, US
Xiaoyue Zhu - Ann Arbor MI, US

International Classification:

B01L 3/00

US Classification:

422100

Abstract:

Microfluidic devices for cell culturing and methods for using the same are disclosed. One device includes a substrate and membrane. The substrate includes a reservoir in fluid communication with a passage. A bio-compatible fluid may be added to the reservoir and passage. The reservoir is configured to receive and retain at least a portion of a cell mass. The membrane acts as a barrier to evaporation of the bio-compatible fluid from the passage. A cover fluid may be added to cover the bio-compatible fluid to prevent evaporation of the bio-compatible fluid.

US Patent:

20100323447, Dec 23, 2010

Filed:

Aug 11, 2010

Appl. No.:

12/854459

Inventors:

Shuichi Takayama - Ann Arbor MI, US
Lourdes Marcella Cabrera - Ann Arbor MI, US
Nobuyuki Futai - Ann Arbor MI, US
Yun Seok Heo - Ann Arbor MI, US
Gary Daniel Smith - Ann Arbor MI, US
Xiaoyue Zhu - Ann Arbor MI, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI

International Classification:

C12N 5/07

US Classification:

435383

Abstract:

Microfluidic devices for cell culturing and methods for using the same are disclosed. One device includes a substrate and membrane. The substrate includes a reservoir in fluid communication with a passage. A bio-compatible fluid may be added to the reservoir and passage. The reservoir is configured to receive and retain at least a portion of a cell mass. The membrane acts as a barrier to evaporation of the bio-compatible fluid from the passage. A cover fluid may be added to cover the bio-compatible fluid to prevent evaporation of the bio-compatible fluid.