Xin Chen

US Patent:

6365711, Apr 2, 2002

Filed:

May 28, 1998

Appl. No.:

09/087134

Inventors:

Malcolm Whitman - Boston MA
Xin Chen - Mountain View CA

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C07K 1447

US Classification:

530300, 530350

Abstract:

FAST-1 and Smad2 or Smad3 form a complex that is specifically induced by signals generated by a TGF- superfamily member. We have shown that a domain of FAST-1 directly interacts with Smad2 or Smad3, and that this interaction is mediated by specific domains of the two interacting molecules, namely, the MH2 domain of Smad2 or Smad3 and the Smad Interaction Domain (SID) of FAST-1. This result allows the development of methods and reagents for the isolation of compounds that are involved in, and/or modulate, TGF- superfamily signalling.

US Patent:

20020160355, Oct 31, 2002

Filed:

Jan 11, 2002

Appl. No.:

10/044442

Inventors:

Malcolm Whitman - Boston MA, US
Xin Chen - Mountain View CA, US

International Classification:

C12Q001/00
C12Q001/68

US Classification:

435/004000, 435/006000

Abstract:

FAST-and Smad2 or Smad3 form a complex that is specifically induced by signals generated by a TGF- superfamily member. We have shown that a domain of FAST-directly interacts with Smad2 or Smad3, and that this interaction is mediated by specific domains of the two interacting molecules, namely, the MH2 domain of Smad2 or Smad3 and the Smad Interaction Domain (SID) of FAST-. This result allows the development of methods and reagents for the isolation of compounds that are involved in, and/or modulate, TGF- superfamily signalling.

US Patent:

20060168259, Jul 27, 2006

Filed:

Jan 27, 2006

Appl. No.:

11/341768

Inventors:

Mark Spilotro - Georgetown TX, US
Xin Chen - Cedar Park TX, US

Assignee:

iKnowWare, LP - Georgetown TX

International Classification:

G06F 15/16

US Classification:

709229000

Abstract:

An intermediary system and method are disclosed for providing users access to enterprise data via the Internet, Wireless PDA, VoIP Phone, Wireless Phone, and GSM/EDGE SmartPhone, and other communication devices. The intermediary system allows users to access enterprise data based on the user's role in the enterprise, the user's assigned privileges, or the user's object permissions. The intermediary system tailors the enterprise data for the user based on the type of communication device of the user, the point in time the user communicates with the system, or the location in a network where the user is communicating with the system. Depending on the above criteria, the user is given a “view” of the enterprise data that relates more directly to the user's current needs, duties, and tasks.

US Patent:

20120181184, Jul 19, 2012

Filed:

Mar 8, 2010

Appl. No.:

13/254967

Inventors:

George M. Whitesides - Newton MA, US
Zhihong Nie - Cambridge MA, US
Christian Nijhuis - Somerville MA, US
Xin Chen - Cambridge MA, US
Andres W. Martinez - Cambridge MA, US
Max Narovlyansky - Cambridge MA, US

Assignee:

PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA

International Classification:

G01N 27/26
G01N 27/416

US Classification:

205775, 204400, 204412

Abstract:

Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fluidic communication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a reference electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of assembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described.

US Patent:

20120272642, Nov 1, 2012

Filed:

Mar 15, 2012

Appl. No.:

13/420886

Inventors:

Cagdas Denizel Onal - Cambridge MA, US
Daniela Rus - Weston MA, US
Xin Chen - Cambridge MA, US
George M. Whitesides - Newton MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA
Massachusetts Institute of Technology - Cambridge MA

International Classification:

F15B 13/16
B01J 19/00

US Classification:

60409, 422129, 422187

Abstract:

Self-regulating pressure source. The pressure source includes a chamber enclosing a chemical monopropellant. A moveable boss is attached to a deformable membrane sealing an air chamber, the moveable boss and air chamber being disposed within the chamber. A catalyst is disposed around the membrane so as to be covered by the boss in a retracted position so that the monopropellant is broken down by the catalyst to produce a gas. The gas pressure will increase within the chamber causing air in the air chamber to compress thereby to pull the boss into the retracted position to cover the catalyst thereby to regulate the pressure within the chamber. The self-regulating pressure source is particularly suited to power fluidic elastomeric actuators.

US Patent:

20130289058, Oct 31, 2013

Filed:

Apr 26, 2013

Appl. No.:

13/871586

Inventors:

Sejal Patel - Lexington MA, US
Justin Mao - North Reading MA, US
Qian Lui - Malden MA, US
Rui Zheng - Chestnut Hill MA, US
Tyler Harrison - Somerville MA, US
Rohit Duvadie - Arlington MA, US
Xin Chen - Lexington MA, US
Frederic Zecri - Brookline MA, US
Jay Larrow - Cambridge MA, US
Xuchun Zheng - Changshu, CN
Yizong Zhou - Changshu, CN
Jiong Ye - Changshu, CN
Yiping Ding - Changshu, CN
Yu Gai - Changshu, CN

International Classification:

C07D 493/08
A61K 31/506
A61K 45/06
A61K 31/4245
A61K 31/422
A61K 31/4439
A61K 31/433

US Classification:

514275, 5462691, 514337, 5462687, 544331, 548138, 514363, 548143, 514364, 548236, 514374, 548234, 514377, 5462714

Abstract:

The invention relates to compounds of formula (I):useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.

US Patent:

20130296598, Nov 7, 2013

Filed:

May 6, 2013

Appl. No.:

13/887968

Inventors:

Pranesh Aswath - Grapevine TX, US
Xin Chen - Dallas TX, US
BoHoon Kim - Yongin-si, KR
Ronald L. Elsenbaumer - Arlington TX, US

Assignee:

Board of Regents, The Univeristy of Texas System - Austin TX

International Classification:

C10M 137/10

US Classification:

558129, 558151

Abstract:

Alkylthioperoxydiphosphates having an alkyl group between about 4 and 18 carbons, a decomposition temperature between about 150 and 300 C. and a wear volume between about 0.0025 and 0.0015 mmin HFRB testing, and methods of making same. Lubricant additives that includes the alkylthioperoxydiphosphates.

US Patent:

20130331305, Dec 12, 2013

Filed:

May 7, 2013

Appl. No.:

13/889037

Inventors:

Pranesh Aswath - Grapevine TX, US
Xin Chen - Dallas TX, US
Vibhu Sharma - Arlington TX, US
Maria Amaya Igartua - Eibar, ES
Francesco Pagano - Eibar, ES
Wolfgang Binder - Halle (Saale), ES
Parvin Zare - Halle(Saale), DE
Nicole Doerr - Wiener Neustadt, AT

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C10M 141/10

US Classification:

508388, 508110, 508433, 508427, 508579, 508547

Abstract:

Anti-wear and/or friction reducing formulations that include a mixture of at least one first ionic liquid and at least one ashless antiwear compound. The ashless antiwear compound can be a second ionic liquid or an ashless thiophosphate compound. The formulation desirably provides synergistic anti-wear and/or friction reducing properties. The first IL can be a monocationie ionic liquid or a dicationic ionic liquid. The second IL is a dicationic ionic liquid. The ashless thiophosphate is desirably a thiophosphate, such as a fluorothiophosphate (FTP), an alkylphosphorofluoridothiolate, or an alkylthioperoxydithiophosphate. Antiwear and/or friction reduction formulations comprising the above mixtures diluted up to 25% by weight in a base oil.