Xin J Chen

US Patent:

6365711, Apr 2, 2002

Filed:

May 28, 1998

Appl. No.:

09/087134

Inventors:

Malcolm Whitman - Boston MA
Xin Chen - Mountain View CA

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C07K 1447

US Classification:

530300, 530350

Abstract:

FAST-1 and Smad2 or Smad3 form a complex that is specifically induced by signals generated by a TGF- superfamily member. We have shown that a domain of FAST-1 directly interacts with Smad2 or Smad3, and that this interaction is mediated by specific domains of the two interacting molecules, namely, the MH2 domain of Smad2 or Smad3 and the Smad Interaction Domain (SID) of FAST-1. This result allows the development of methods and reagents for the isolation of compounds that are involved in, and/or modulate, TGF- superfamily signalling.

US Patent:

20020160355, Oct 31, 2002

Filed:

Jan 11, 2002

Appl. No.:

10/044442

Inventors:

Malcolm Whitman - Boston MA, US
Xin Chen - Mountain View CA, US

International Classification:

C12Q001/00
C12Q001/68

US Classification:

435/004000, 435/006000

Abstract:

FAST-and Smad2 or Smad3 form a complex that is specifically induced by signals generated by a TGF- superfamily member. We have shown that a domain of FAST-directly interacts with Smad2 or Smad3, and that this interaction is mediated by specific domains of the two interacting molecules, namely, the MH2 domain of Smad2 or Smad3 and the Smad Interaction Domain (SID) of FAST-. This result allows the development of methods and reagents for the isolation of compounds that are involved in, and/or modulate, TGF- superfamily signalling.

US Patent:

20120181184, Jul 19, 2012

Filed:

Mar 8, 2010

Appl. No.:

13/254967

Inventors:

George M. Whitesides - Newton MA, US
Zhihong Nie - Cambridge MA, US
Christian Nijhuis - Somerville MA, US
Xin Chen - Cambridge MA, US
Andres W. Martinez - Cambridge MA, US
Max Narovlyansky - Cambridge MA, US

Assignee:

PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA

International Classification:

G01N 27/26
G01N 27/416

US Classification:

205775, 204400, 204412

Abstract:

Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fluidic communication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a reference electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of assembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described.

US Patent:

20120272642, Nov 1, 2012

Filed:

Mar 15, 2012

Appl. No.:

13/420886

Inventors:

Cagdas Denizel Onal - Cambridge MA, US
Daniela Rus - Weston MA, US
Xin Chen - Cambridge MA, US
George M. Whitesides - Newton MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA
Massachusetts Institute of Technology - Cambridge MA

International Classification:

F15B 13/16
B01J 19/00

US Classification:

60409, 422129, 422187

Abstract:

Self-regulating pressure source. The pressure source includes a chamber enclosing a chemical monopropellant. A moveable boss is attached to a deformable membrane sealing an air chamber, the moveable boss and air chamber being disposed within the chamber. A catalyst is disposed around the membrane so as to be covered by the boss in a retracted position so that the monopropellant is broken down by the catalyst to produce a gas. The gas pressure will increase within the chamber causing air in the air chamber to compress thereby to pull the boss into the retracted position to cover the catalyst thereby to regulate the pressure within the chamber. The self-regulating pressure source is particularly suited to power fluidic elastomeric actuators.

US Patent:

20130289058, Oct 31, 2013

Filed:

Apr 26, 2013

Appl. No.:

13/871586

Inventors:

Sejal Patel - Lexington MA, US
Justin Mao - North Reading MA, US
Qian Lui - Malden MA, US
Rui Zheng - Chestnut Hill MA, US
Tyler Harrison - Somerville MA, US
Rohit Duvadie - Arlington MA, US
Xin Chen - Lexington MA, US
Frederic Zecri - Brookline MA, US
Jay Larrow - Cambridge MA, US
Xuchun Zheng - Changshu, CN
Yizong Zhou - Changshu, CN
Jiong Ye - Changshu, CN
Yiping Ding - Changshu, CN
Yu Gai - Changshu, CN

International Classification:

C07D 493/08
A61K 31/506
A61K 45/06
A61K 31/4245
A61K 31/422
A61K 31/4439
A61K 31/433

US Classification:

514275, 5462691, 514337, 5462687, 544331, 548138, 514363, 548143, 514364, 548236, 514374, 548234, 514377, 5462714

Abstract:

The invention relates to compounds of formula (I):useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.

US Patent:

58328270, Nov 10, 1998

Filed:

Jul 11, 1997

Appl. No.:

8/893703

Inventors:

Steve J. Pistro - Willamsville NY
Xin Chen - Westborough MA

Assignee:

Moore Business Forms, Inc. - Grand Island NY

International Classification:

B41F 108

US Classification:

101288

Abstract:

A method of printing on a release layer of linerless label material including the step of advancing linerless label material and a thermal transfer ribbon coated with ink through a thermal printer. The ribbon is moved over a heated transfer element of the printer. The heated transfer element is located on an edge or on a corner of an edge of the thermal printer. The ribbon is then heated to cause the ink to reach a molten or fluid state. The ink transfers in its molten or fluid state to the release layer of the linerless label material. Certain wax/resin and resin based thermal transfer ribbons and silicone release coatings have been found to be particularly effective for increasing the ink transfer and anchorage during corner edge and true edge printing on linerless label material.

US Patent:

20220411435, Dec 29, 2022

Filed:

Aug 8, 2022

Appl. No.:

17/818321

Inventors:

- Basel, CH
Xin CHEN - Lexington MA, US
Kevin Matthew GARDINIER - Arlington MA, US
Edward Charles HALL - Boston MA, US
Keith JENDZA - Boston MA, US
Nancy LABBE-GIGUERE - Arlington MA, US
James NEEF - Stow MA, US
Daniel Steven PALACIOS - Cambridge MA, US
Ming QIAN - Watertown MA, US
Michael David SHULTZ - Lexington MA, US
Christopher G. THOMSON - Herts, GB
Kate Yaping WANG - Boxborough MA, US
Fan YANG - West Roxbury MA, US

International Classification:

C07D 491/107
A61P 25/18
A61K 45/06

Abstract:

Provided herein are compounds according to Formula (I)or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, and Rare defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

US Patent:

20210130365, May 6, 2021

Filed:

Oct 7, 2020

Appl. No.:

17/065367

Inventors:

- Basel, CH
Xin CHEN - Lexington MA, US
Kevin Matthew GARDINIER - Arlington MA, US
Edward Charles HALL - Boston MA, US
Keith JENDZA - Boston MA, US
Nancy LABBE-GIGUERE - Arlington MA, US
James NEEF - Stow MA, US
Daniel Steven PALACIOS - Cambridge MA, US
Ming QIAN - Watertown MA, US
Michael David SHULTZ - Lexington MA, US
Christopher G. THOMSON - Herts, GB
Kate Yaping WANG - Boxborough MA, US
Fan YANG - West Roxbury MA, US

International Classification:

C07D 491/107
A61K 45/06
A61P 25/18

Abstract:

Provided herein are compounds according to Formula (I)or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, and Rare defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.