Xin M Chen

US Patent:

7208612, Apr 24, 2007

Filed:

Aug 22, 2002

Appl. No.:

10/227400

Inventors:

Bonnie L. Bassler - Princeton NJ, US
Stephan Schauder - Lyons, FR
Xin Chen - Edison NJ, US
Frederick M. Hughson - Princeton NJ, US
Stephen R. Cooper - Carlsbad CA, US

Assignee:

Princeton University - Princeton NJ

International Classification:

C07D 307/94
A01N 43/30

US Classification:

549213, 514462

Abstract:

A crystal comprising LuxP is obtained, and a binding site for autoinducer-2 (AI-2) identified. The X-ray crystallographic data for LuxP and a LuxP-AI-2 complex is determined and used in a drug discovery method. Pharmaceutical compositions comprising ligands identified by such drug discovery methods are used to treat bacterial infections.

US Patent:

7700594, Apr 20, 2010

Filed:

Nov 15, 2006

Appl. No.:

11/599663

Inventors:

Xin Chen - Farmingdale NY, US
Heather Coate - Farmingdale NY, US
Andrew Philip Crew - Farmingdale NY, US
Ayako Honda - Farmingdale NY, US
Mark Joseph Mulvihill - Farmingdale NY, US
Paula A. R. Tavares - Farmingdale NY, US
Jing Wang - Farmingdale NY, US
Douglas S. Werner - Farmingdale NY, US
Kristen Michelle Mulvihill - Farmingdale NY, US
Kam W. Siu - Farmingdale NY, US
Bijoy Panicker - Farmingdale NY, US
Apoorba Bharadwaj - Farmingdale NY, US
Lee D. Arnold - Farmingdale NY, US
Meizhong Jin - Farmingdale NY, US
Brian Volk - Farmingdale NY, US
Qinghua Weng - Farmingdale NY, US
James David Beard - Farmingdale NY, US

Assignee:

OSI Pharmaceuticals, Inc. - Melville NY

International Classification:

C07D 487/04
C07D 401/14
C07D 403/04
A61K 31/53
A61K 31/4523
A61K 35/00

US Classification:

514243, 544184

Abstract:

Compounds represented by Formula (I).

US Patent:

8111957, Feb 7, 2012

Filed:

Jul 7, 2009

Appl. No.:

12/498591

Inventors:

Robert R Alfano - Bronx NY, US
Xin Chen - Corning NY, US
Joohyun Koh - Painted Post NY, US
Ming-Jun Li - Horseheads NY, US
Daniel Aloysius Nolan - Corning NY, US
Henry Sztul - New York NY, US

Assignee:

Corning Incorporated - Corning NY

International Classification:

G02B 6/26
G01N 21/00

US Classification:

385 28, 356 731

Abstract:

Generation of a cylindrically polarized light beam, and in particular, a hybrid-azimuthal-radial polarization beams, called HARP modes, generated from an input linearly polarized Gaussian beam using a spun optical waveguide device is taught. The HARP modes are comprised of hybrid-azimuthal polarization (HAP) and hybrid-radial polarization (HRP) superposition modes. These beams possess a non-zero local angular momentum density that is spatially varying and a zero total angular momentum.

US Patent:

20070185314, Aug 9, 2007

Filed:

Feb 28, 2007

Appl. No.:

11/711935

Inventors:

Bonnie Bassler - Princeton NJ, US
Stephan Schauder - Lyon, FR
Xin Chen - Edison NJ, US
Frederick Hughson - Princeton NJ, US
Stephen Cooper - Carlsbad CA, US

International Classification:

C07K 14/195
G06F 19/00

US Classification:

530350000, 702019000

Abstract:

A crystal comprising LuxP is obtained, and a binding site for autoinducer-2 (AI-2) identified. The X-ray crystallographic data for LuxP and a LuxP-AI-2 complex is determined and used in a drug discovery method. Pharmaceutical compositions comprising ligands identified by such drug discovery methods are used to treat bacterial infections.

US Patent:

20070208053, Sep 6, 2007

Filed:

Jan 18, 2007

Appl. No.:

11/654814

Inventors:

Lee Arnold - Farmingdale NY, US
Xin Chen - Farmingdale NY, US
Hanqing Dong - Farmingdale NY, US
Andrew Garton - Farmingdale NY, US
Mark Mulvihill - Farmingdale NY, US
Colin Sambrook Smith - Oxford, GB
Gerard Thomas - Oxford, GB
Thomas Krulle - Oxford, GB
Jing Wang - Farmingdale NY, US

International Classification:

C07D 471/02
A61K 31/4745

US Classification:

514300000, 546113000

Abstract:

Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X, X, X, X, X, X, X, R, and Qare defined herein, inhibit kinase enzymes and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer. The compounds are also useful in the treatment of inflammation, allergy, asthma, disease and conditions of the immune system, disease and conditions of the nervous system, cardiovascular diseases, disease and conditions of the eye, dermatological diseases, osteoporosis, diabetes, multiple sclerosis, and infections.

US Patent:

20090305960, Dec 10, 2009

Filed:

Jun 8, 2009

Appl. No.:

12/480420

Inventors:

Xin Chen - Furlong PA, US
Shubh D. Sharma - Cranbury NJ, US
Yi-Qun Shi - East Brunswick NJ, US
Wei Yang - Edison NJ, US

Assignee:

Palatin Technologies, Inc - Cranbury NJ

International Classification:

A61K 38/12
C07K 7/64
A61P 3/00

US Classification:

514 11, 530321

Abstract:

Melanocortin receptor-specific cyclic peptides of the formulawhere R, R, R, R, x and y are as defined in the specification, compositions and formulations including the peptides of the foregoing formula, and methods of preventing, ameliorating or treating melanocortin receptor-mediated diseases, indications, conditions and syndromes, including obesity, diabetes, modulation of feeding behavior and related metabolic syndrome.

US Patent:

20120077957, Mar 29, 2012

Filed:

Dec 6, 2011

Appl. No.:

13/311817

Inventors:

Xin Chen - Furlong PA, US
Wei Yang - Edison NJ, US

Assignee:

PALATIN TECHNOLOGIES, INC. - Cranbury NJ

International Classification:

C07K 7/54

US Classification:

530323

Abstract:

Lactam-bridged melanocortin receptor-specific cyclic peptides of the formulawhere R, R, R, R, R, R, R, Rand Rare as defined in the specification, compositions and formulations including the peptides of the foregoing formula, and methods of preventing, ameliorating or treating melanocortin receptor-mediated diseases, indications, conditions and syndromes, including obesity, modulation of feeding behavior, related metabolic syndrome, sexual dysfunction, male erectile dysfunction and female sexual dysfunction.

US Patent:

20120178701, Jul 12, 2012

Filed:

Dec 6, 2011

Appl. No.:

13/311824

Inventors:

Yi-qun Shi - East Brunswick NJ, US
Shubh D. Sharma - Cranbury NJ, US
John H. Dodd - Flemington NJ, US
Wei Yang - Edison NJ, US
Xin Chen - Furlong PA, US

Assignee:

PALATIN TECHNOLOGIES, INC. - Cranbury NJ

International Classification:

A61K 38/12
A61P 3/00
A61P 3/04
A61P 15/00
C07K 7/54
A61P 15/10

US Classification:

514 206, 530317, 514 211

Abstract:

Melanocortin receptor-specific cyclic peptides of the formulawhere R, R, R, R, R, R, R, R, R, Rand z are as defined in the specification, compositions and formulations including the peptides of the foregoing formula, and methods of preventing, ameliorating or treating melanocortin receptor-mediated diseases, indications, conditions and syndromes.