Xin Chen

US Patent:

6365711, Apr 2, 2002

Filed:

May 28, 1998

Appl. No.:

09/087134

Inventors:

Malcolm Whitman - Boston MA
Xin Chen - Mountain View CA

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C07K 1447

US Classification:

530300, 530350

Abstract:

FAST-1 and Smad2 or Smad3 form a complex that is specifically induced by signals generated by a TGF- superfamily member. We have shown that a domain of FAST-1 directly interacts with Smad2 or Smad3, and that this interaction is mediated by specific domains of the two interacting molecules, namely, the MH2 domain of Smad2 or Smad3 and the Smad Interaction Domain (SID) of FAST-1. This result allows the development of methods and reagents for the isolation of compounds that are involved in, and/or modulate, TGF- superfamily signalling.

US Patent:

8111957, Feb 7, 2012

Filed:

Jul 7, 2009

Appl. No.:

12/498591

Inventors:

Robert R Alfano - Bronx NY, US
Xin Chen - Corning NY, US
Joohyun Koh - Painted Post NY, US
Ming-Jun Li - Horseheads NY, US
Daniel Aloysius Nolan - Corning NY, US
Henry Sztul - New York NY, US

Assignee:

Corning Incorporated - Corning NY

International Classification:

G02B 6/26
G01N 21/00

US Classification:

385 28, 356 731

Abstract:

Generation of a cylindrically polarized light beam, and in particular, a hybrid-azimuthal-radial polarization beams, called HARP modes, generated from an input linearly polarized Gaussian beam using a spun optical waveguide device is taught. The HARP modes are comprised of hybrid-azimuthal polarization (HAP) and hybrid-radial polarization (HRP) superposition modes. These beams possess a non-zero local angular momentum density that is spatially varying and a zero total angular momentum.

US Patent:

20020160355, Oct 31, 2002

Filed:

Jan 11, 2002

Appl. No.:

10/044442

Inventors:

Malcolm Whitman - Boston MA, US
Xin Chen - Mountain View CA, US

International Classification:

C12Q001/00
C12Q001/68

US Classification:

435/004000, 435/006000

Abstract:

FAST-and Smad2 or Smad3 form a complex that is specifically induced by signals generated by a TGF- superfamily member. We have shown that a domain of FAST-directly interacts with Smad2 or Smad3, and that this interaction is mediated by specific domains of the two interacting molecules, namely, the MH2 domain of Smad2 or Smad3 and the Smad Interaction Domain (SID) of FAST-. This result allows the development of methods and reagents for the isolation of compounds that are involved in, and/or modulate, TGF- superfamily signalling.

US Patent:

20120178701, Jul 12, 2012

Filed:

Dec 6, 2011

Appl. No.:

13/311824

Inventors:

Yi-qun Shi - East Brunswick NJ, US
Shubh D. Sharma - Cranbury NJ, US
John H. Dodd - Flemington NJ, US
Wei Yang - Edison NJ, US
Xin Chen - Furlong PA, US

Assignee:

PALATIN TECHNOLOGIES, INC. - Cranbury NJ

International Classification:

A61K 38/12
A61P 3/00
A61P 3/04
A61P 15/00
C07K 7/54
A61P 15/10

US Classification:

514 206, 530317, 514 211

Abstract:

Melanocortin receptor-specific cyclic peptides of the formulawhere R, R, R, R, R, R, R, R, R, Rand z are as defined in the specification, compositions and formulations including the peptides of the foregoing formula, and methods of preventing, ameliorating or treating melanocortin receptor-mediated diseases, indications, conditions and syndromes.

US Patent:

20120181184, Jul 19, 2012

Filed:

Mar 8, 2010

Appl. No.:

13/254967

Inventors:

George M. Whitesides - Newton MA, US
Zhihong Nie - Cambridge MA, US
Christian Nijhuis - Somerville MA, US
Xin Chen - Cambridge MA, US
Andres W. Martinez - Cambridge MA, US
Max Narovlyansky - Cambridge MA, US

Assignee:

PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA

International Classification:

G01N 27/26
G01N 27/416

US Classification:

205775, 204400, 204412

Abstract:

Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fluidic communication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a reference electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of assembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described.

US Patent:

20120272642, Nov 1, 2012

Filed:

Mar 15, 2012

Appl. No.:

13/420886

Inventors:

Cagdas Denizel Onal - Cambridge MA, US
Daniela Rus - Weston MA, US
Xin Chen - Cambridge MA, US
George M. Whitesides - Newton MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA
Massachusetts Institute of Technology - Cambridge MA

International Classification:

F15B 13/16
B01J 19/00

US Classification:

60409, 422129, 422187

Abstract:

Self-regulating pressure source. The pressure source includes a chamber enclosing a chemical monopropellant. A moveable boss is attached to a deformable membrane sealing an air chamber, the moveable boss and air chamber being disposed within the chamber. A catalyst is disposed around the membrane so as to be covered by the boss in a retracted position so that the monopropellant is broken down by the catalyst to produce a gas. The gas pressure will increase within the chamber causing air in the air chamber to compress thereby to pull the boss into the retracted position to cover the catalyst thereby to regulate the pressure within the chamber. The self-regulating pressure source is particularly suited to power fluidic elastomeric actuators.

US Patent:

20130231306, Sep 5, 2013

Filed:

Jan 25, 2013

Appl. No.:

13/749758

Inventors:

Dan Sherman - New York NY, US
Rama Devi Appari - Port Jefferson Station NY, US
Xin Chen - Commack NY, US
Ramesh Chilukuri - Budha Nagar near Uppal Depot NY, US
Hanqing Dong - Syosset NY, US
Caterina Ferraro - Fresh Meadows NY, US
Kenneth Foreman - Syosset NY, US
Ramesh C. Gupta - Port Jefferson Station NY, US
An-Hu Li - Commack NY, US
Kathryn M. Stolz - Williston Park NY, US
Brian Volk - Sayville NY, US
Robert Zahler - Pennington NJ, US

Assignee:

OSI Pharmaceuticals, LLC - Farmingdale NY

International Classification:

C07F 9/6558
C07F 9/6544
C07F 9/6512

US Classification:

514 81, 544232, 514 86, 544105, 544 57, 514 80, 514 82

Abstract:

Compounds of Formula 1, as shown below and defined herein:

US Patent:

20130289058, Oct 31, 2013

Filed:

Apr 26, 2013

Appl. No.:

13/871586

Inventors:

Sejal Patel - Lexington MA, US
Justin Mao - North Reading MA, US
Qian Lui - Malden MA, US
Rui Zheng - Chestnut Hill MA, US
Tyler Harrison - Somerville MA, US
Rohit Duvadie - Arlington MA, US
Xin Chen - Lexington MA, US
Frederic Zecri - Brookline MA, US
Jay Larrow - Cambridge MA, US
Xuchun Zheng - Changshu, CN
Yizong Zhou - Changshu, CN
Jiong Ye - Changshu, CN
Yiping Ding - Changshu, CN
Yu Gai - Changshu, CN

International Classification:

C07D 493/08
A61K 31/506
A61K 45/06
A61K 31/4245
A61K 31/422
A61K 31/4439
A61K 31/433

US Classification:

514275, 5462691, 514337, 5462687, 544331, 548138, 514363, 548143, 514364, 548236, 514374, 548234, 514377, 5462714

Abstract:

The invention relates to compounds of formula (I):useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.