Xin Chen

US Patent:

20120181184, Jul 19, 2012

Filed:

Mar 8, 2010

Appl. No.:

13/254967

Inventors:

George M. Whitesides - Newton MA, US
Zhihong Nie - Cambridge MA, US
Christian Nijhuis - Somerville MA, US
Xin Chen - Cambridge MA, US
Andres W. Martinez - Cambridge MA, US
Max Narovlyansky - Cambridge MA, US

Assignee:

PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA

International Classification:

G01N 27/26
G01N 27/416

US Classification:

205775, 204400, 204412

Abstract:

Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fluidic communication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a reference electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of assembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described.

US Patent:

20120272642, Nov 1, 2012

Filed:

Mar 15, 2012

Appl. No.:

13/420886

Inventors:

Cagdas Denizel Onal - Cambridge MA, US
Daniela Rus - Weston MA, US
Xin Chen - Cambridge MA, US
George M. Whitesides - Newton MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA
Massachusetts Institute of Technology - Cambridge MA

International Classification:

F15B 13/16
B01J 19/00

US Classification:

60409, 422129, 422187

Abstract:

Self-regulating pressure source. The pressure source includes a chamber enclosing a chemical monopropellant. A moveable boss is attached to a deformable membrane sealing an air chamber, the moveable boss and air chamber being disposed within the chamber. A catalyst is disposed around the membrane so as to be covered by the boss in a retracted position so that the monopropellant is broken down by the catalyst to produce a gas. The gas pressure will increase within the chamber causing air in the air chamber to compress thereby to pull the boss into the retracted position to cover the catalyst thereby to regulate the pressure within the chamber. The self-regulating pressure source is particularly suited to power fluidic elastomeric actuators.

US Patent:

20130289058, Oct 31, 2013

Filed:

Apr 26, 2013

Appl. No.:

13/871586

Inventors:

Sejal Patel - Lexington MA, US
Justin Mao - North Reading MA, US
Qian Lui - Malden MA, US
Rui Zheng - Chestnut Hill MA, US
Tyler Harrison - Somerville MA, US
Rohit Duvadie - Arlington MA, US
Xin Chen - Lexington MA, US
Frederic Zecri - Brookline MA, US
Jay Larrow - Cambridge MA, US
Xuchun Zheng - Changshu, CN
Yizong Zhou - Changshu, CN
Jiong Ye - Changshu, CN
Yiping Ding - Changshu, CN
Yu Gai - Changshu, CN

International Classification:

C07D 493/08
A61K 31/506
A61K 45/06
A61K 31/4245
A61K 31/422
A61K 31/4439
A61K 31/433

US Classification:

514275, 5462691, 514337, 5462687, 544331, 548138, 514363, 548143, 514364, 548236, 514374, 548234, 514377, 5462714

Abstract:

The invention relates to compounds of formula (I):useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.

US Patent:

20220411435, Dec 29, 2022

Filed:

Aug 8, 2022

Appl. No.:

17/818321

Inventors:

- Basel, CH
Xin CHEN - Lexington MA, US
Kevin Matthew GARDINIER - Arlington MA, US
Edward Charles HALL - Boston MA, US
Keith JENDZA - Boston MA, US
Nancy LABBE-GIGUERE - Arlington MA, US
James NEEF - Stow MA, US
Daniel Steven PALACIOS - Cambridge MA, US
Ming QIAN - Watertown MA, US
Michael David SHULTZ - Lexington MA, US
Christopher G. THOMSON - Herts, GB
Kate Yaping WANG - Boxborough MA, US
Fan YANG - West Roxbury MA, US

International Classification:

C07D 491/107
A61P 25/18
A61K 45/06

Abstract:

Provided herein are compounds according to Formula (I)or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, and Rare defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

US Patent:

20210130365, May 6, 2021

Filed:

Oct 7, 2020

Appl. No.:

17/065367

Inventors:

- Basel, CH
Xin CHEN - Lexington MA, US
Kevin Matthew GARDINIER - Arlington MA, US
Edward Charles HALL - Boston MA, US
Keith JENDZA - Boston MA, US
Nancy LABBE-GIGUERE - Arlington MA, US
James NEEF - Stow MA, US
Daniel Steven PALACIOS - Cambridge MA, US
Ming QIAN - Watertown MA, US
Michael David SHULTZ - Lexington MA, US
Christopher G. THOMSON - Herts, GB
Kate Yaping WANG - Boxborough MA, US
Fan YANG - West Roxbury MA, US

International Classification:

C07D 491/107
A61K 45/06
A61P 25/18

Abstract:

Provided herein are compounds according to Formula (I)or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, and Rare defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

US Patent:

20210107889, Apr 15, 2021

Filed:

Oct 7, 2020

Appl. No.:

17/065360

Inventors:

- Basel, CH
Xin CHEN - Lexington MA, US
Kevin Matthew GARDINIER - Arlington MA, US
Edward Charles HALL - Boston MA, US
Keith JENDZA - Boston MA, US
Nancy LABBE-GIGUERE - Arlington MA, US
James NEEF - Stow MA, US
Daniel Steven PALACIOS - Cambridge MA, US
Ming QIAN - Watertown MA, US
Michael David SHULTZ - Lexington MA, US
Christopher G. THOMSON - Herts, GB
Kate Yaping WANG - Boxborough MA, US
Fan YANG - West Roxbury MA, US

International Classification:

C07D 401/04

Abstract:

Provided herein are compounds according to Formula (I)or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, and Rare defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

US Patent:

20180363683, Dec 20, 2018

Filed:

Apr 13, 2018

Appl. No.:

15/953198

Inventors:

- Cambridge MA, US
Adam STOKES - Watertown MA, US
Stephen A. MORIN - Lincoln NE, US
Ludovico CADEMARTIRI - Somerville MA, US
Jacob FREAKE - Willimantic CT, US
Rui NUNES - Somerville MA, US
Xin CHEN - Cambridge MA, US
George M. WHITESIDES - Newton MA, US

International Classification:

F15B 13/04
B25J 9/10
B25J 9/14

Abstract:

Systems and methods for providing a soft robot is provided. In one system, a robotic device includes a flexible body having a fluid chamber, where a portion of the flexible body includes an elastically extensible material and a portion of the flexible body is strain limiting relative to the elastically extensible material. The robotic device can further include a pressurizing inlet in fluid communication with the fluid chamber, and a pressurizing device in fluid communication with the pressurizing inlet, the pressurizing device including a reaction chamber configured to accommodate a gas-producing chemical reaction for providing pressurized gas to the pressurizing inlet.

US Patent:

20170124596, May 4, 2017

Filed:

Oct 28, 2016

Appl. No.:

15/337562

Inventors:

- Waltham MA, US
Xin Chen - Waltham MA, US

International Classification:

G06Q 30/02

Abstract:

A method relates to receiving, by a processing device executing a decision framework, a request comprising a plurality of attribute values associated with an opportunity to place an ad on one or more devices associated with a user, generating a state dynamic model comprising a plurality of state variables based on the plurality of attribute values associated with the opportunity, determining a plurality of utility functions, wherein each one of the plurality of utility function is determined based on at least one of the plurality of state variables, calculating a decision based on the plurality of utility functions, wherein the decision comprises finding an extreme value of the utility functions to match one or more ads to the ad opportunity, and causing to provide the ad to a selection the one or more devices.