Xin Chen

US Patent:

7700594, Apr 20, 2010

Filed:

Nov 15, 2006

Appl. No.:

11/599663

Inventors:

Xin Chen - Farmingdale NY, US
Heather Coate - Farmingdale NY, US
Andrew Philip Crew - Farmingdale NY, US
Ayako Honda - Farmingdale NY, US
Mark Joseph Mulvihill - Farmingdale NY, US
Paula A. R. Tavares - Farmingdale NY, US
Jing Wang - Farmingdale NY, US
Douglas S. Werner - Farmingdale NY, US
Kristen Michelle Mulvihill - Farmingdale NY, US
Kam W. Siu - Farmingdale NY, US
Bijoy Panicker - Farmingdale NY, US
Apoorba Bharadwaj - Farmingdale NY, US
Lee D. Arnold - Farmingdale NY, US
Meizhong Jin - Farmingdale NY, US
Brian Volk - Farmingdale NY, US
Qinghua Weng - Farmingdale NY, US
James David Beard - Farmingdale NY, US

Assignee:

OSI Pharmaceuticals, Inc. - Melville NY

International Classification:

C07D 487/04
C07D 401/14
C07D 403/04
A61K 31/53
A61K 31/4523
A61K 35/00

US Classification:

514243, 544184

Abstract:

Compounds represented by Formula (I).

US Patent:

7923555, Apr 12, 2011

Filed:

Dec 2, 2008

Appl. No.:

12/326536

Inventors:

Xin Chen - Commack NY, US
Heather Coate - San Diego CA, US
Andrew Philip Crew - N. Babylon NY, US
Hanqing Dong - Syosset NY, US
Ayako Honda - Quincy MA, US
Mark Joseph Mulvihill - East Northport NY, US
Paula A. R. Tavares - Kew Gardens NY, US
Jing Wang - Syosset NY, US
Douglas S. Werner - Holtsville NY, US
Kristen Michelle Mulvihill - E. Northport NY, US
Kam W. Siu - Farmingdale NY, US
Bijoy Panicker - Holbrook NY, US
Apoorba Bharadwaj - Jamestown NC, US
Lee D. Arnold - Mt. Sinai NY, US
Meizhong Jin - Dix Hills NY, US
Brian Volk - Sayville NY, US
Quinghua Weng - West Islip NY, US
James David Beard - New York NY, US

Assignee:

OSI Pharmaceuticals, Inc. - Ardsley NY

International Classification:

C07D 487/04
C07D 403/04
C07D 403/14
A61K 31/519
A61P 19/02

US Classification:

544256, 5142621, 514243, 544184

Abstract:

Compounds represented by Formula (I).

US Patent:

7943767, May 17, 2011

Filed:

Nov 20, 2009

Appl. No.:

12/622545

Inventors:

Xin Chen - Commack NY, US
Heather Coate - San Diego CA, US
Andrew Philip Crew - N. Babylon NY, US
Ayako Honda - Quincy MA, US
Mark Joseph Mulvihill - East Northport NY, US
Paula A. R. Tavares - Kew Gardens NY, US
Jing Wang - Syosset NY, US
Douglas S. Werner - Holtsville NY, US
Kristen Michelle Mulvihill - E. Northport NY, US
Kam W. Siu - Farmingdale NY, US
Bijoy Panicker - Holtsville NY, US
Apoorba Bharadwaj - Jamestown NC, US
Lee D. Arnold - Mt. Sinai NY, US
Meizhong Jin - Dix Hills NY, US
Brian Volk - Sayville NY, US
Quinghua Weng - West Islip NY, US
James David Beard - New York NY, US

Assignee:

OSI Pharmaceuticals, Inc. - Ardsley NY

International Classification:

C07D 487/04
C07D 403/04
C07D 401/14
A61K 31/53
A61P 35/00

US Classification:

544184, 514243

Abstract:

Compounds represented by Formula (I).

US Patent:

8022206, Sep 20, 2011

Filed:

Feb 6, 2009

Appl. No.:

12/366743

Inventors:

An-Hu Li - Commack NY, US
Arno G. Steinig - East Northport NY, US
Andrew Kleinberg - East Meadow NY, US
Qinghua Weng - West Islip NY, US
Mark J. Mulvihill - East Northport NY, US
Jing Wang - Syosset NY, US
Xin Chen - Commack NY, US
Ti Wang - Evanston IL, US
Hanqing Dong - Syosset NY, US
Meizhong Jin - Dix Hills NY, US

Assignee:

OSI Pharmaceuticals, LLC - Farmingdale NY

International Classification:

C07D 413/00
C07D 403/00
C07D 471/02

US Classification:

544127, 544362, 546116

Abstract:

Furo[3,2-c]Pyridine and Thieno[3,2-c]pyridine compounds of Formula I, and pharmaceutically acceptable salts thereof, preparation, intermediates, pharmaceutical compositions, and use, such as in disease treatment, including cancers, including conditions in which EMT is involved, including conditions mediated by protein kinase activity such as RON and/or MET.

US Patent:

8111957, Feb 7, 2012

Filed:

Jul 7, 2009

Appl. No.:

12/498591

Inventors:

Robert R Alfano - Bronx NY, US
Xin Chen - Corning NY, US
Joohyun Koh - Painted Post NY, US
Ming-Jun Li - Horseheads NY, US
Daniel Aloysius Nolan - Corning NY, US
Henry Sztul - New York NY, US

Assignee:

Corning Incorporated - Corning NY

International Classification:

G02B 6/26
G01N 21/00

US Classification:

385 28, 356 731

Abstract:

Generation of a cylindrically polarized light beam, and in particular, a hybrid-azimuthal-radial polarization beams, called HARP modes, generated from an input linearly polarized Gaussian beam using a spun optical waveguide device is taught. The HARP modes are comprised of hybrid-azimuthal polarization (HAP) and hybrid-radial polarization (HRP) superposition modes. These beams possess a non-zero local angular momentum density that is spatially varying and a zero total angular momentum.

US Patent:

8178668, May 15, 2012

Filed:

Feb 4, 2009

Appl. No.:

12/365325

Inventors:

Arno G. Steinig - East Northport NY, US
Mark J. Mulvihill - East Northport NY, US
Jing Wang - Syosset NY, US
Douglas S. Werner - Holtsville NY, US
Qinghua Weng - West Islip NY, US
Heather Coate - San Diego CA, US
Xin Chen - Commack NY, US

Assignee:

OSI Pharmaceuticals, LLC - Farmingdale NY

International Classification:

C07D 401/14
C07D 405/14
C07D 413/14
C07D 417/14
C07D 451/02
C07D 471/04
C07D 487/04

US Classification:

544128, 544350, 544363, 546121, 546126, 546144, 546148, 546194, 5462717

Abstract:

2-Aminopyridine compounds having the structure of Formula I, and pharmaceutically acceptable salts of these compounds. Compounds of Formula I inhibit the activity of tyrosine kinase enzymes in animals, including humans, and are useful in the treatment and/or prevention of various diseases and conditions. In particular, compounds disclosed herein are inhibitors of kinases, in particular, but not limited to, KDR, Tie-2, Flt3, FGFR3, Ab1, Aurora A, c-Src, IGF-1R, ALK, c-MET, RON, PAK1, PAK2, and TAK1, and can be used in the treatment of proliferative diseases, such as, but not limited to, cancer. The present invention is also directed to a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula I, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The present invention is further directed to a method of treating a patient having a condition which is mediated by protein kinase activity by administering to the patient a therapeutically effective amount of the above-mentioned pharmaceutical composition.

US Patent:

8314111, Nov 20, 2012

Filed:

May 13, 2011

Appl. No.:

13/106954

Inventors:

Xin Chen - Commack NY, US
Heather Coate - San Diego CA, US
Andrew Philip Crew - N. Babylon NY, US
Ayako Honda - Quincy MA, US
Mark Joseph Mulvihill - Melville NY, US
Paula A. R. Tavares - Kew Gardens NY, US
Jing Wang - Syosset NY, US
Douglas S. Werner - Holtsville NY, US
Kam W. Siu - Farmingdale NY, US
Bijoy Panicker - Holbrook NY, US
Apoorba Bharadwaj - Jamestown NC, US
Lee D. Arnold - Mt. Sinai NY, US
Meizhong Jin - Dix Hills NY, US
Brian Volk - Sayville NY, US
Quinghua Weng - West Islip NY, US
James David Beard - New York NY, US

Assignee:

OSI Pharmaceuticals, LLC - Farmingdale NY

International Classification:

C07D 487/04
C07D 403/04
C07D 403/14
A61K 31/519
A61P 19/02

US Classification:

5142621, 544256

Abstract:

Compounds represented by Formula (I).

US Patent:

8378104, Feb 19, 2013

Filed:

Feb 11, 2011

Appl. No.:

13/025281

Inventors:

Keith R. Hornberger - Mount Sinai NY, US
Dan M. Berger - New City NY, US
Xin Chen - Commack NY, US
Andrew P. Crew - N. Babylon NY, US
Hanqing Dong - Syosset NY, US
Andrew Kleinberg - East Meadow NY, US
An-Hu Li - Commack NY, US
Lifu Ma - Melville NY, US
Mark J. Mulvihill - Melville NY, US
Bijoy Panicker - Holbrook NY, US
Kam W. Siu - Farmingdale NY, US
Arno G. Steinig - East Northport NY, US
James G. Tarrant - Lindenhurst NY, US
Jing Wang - Syosset NY, US
Qinghua Weng - Hicksville NY, US
Rajaram Sangem - Port Jefferson Station NY, US
Ramesh C. Gupta - Port Jefferson Station NY, US

Assignee:

OSI Pharmaceuticals, LLC - Farmingdale NY

International Classification:

C07D 471/02

US Classification:

546115

Abstract:

Compounds of Formula 1, as shown below and defined herein:.