Xin J Chen

US Patent:

6365711, Apr 2, 2002

Filed:

May 28, 1998

Appl. No.:

09/087134

Inventors:

Malcolm Whitman - Boston MA
Xin Chen - Mountain View CA

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C07K 1447

US Classification:

530300, 530350

Abstract:

FAST-1 and Smad2 or Smad3 form a complex that is specifically induced by signals generated by a TGF- superfamily member. We have shown that a domain of FAST-1 directly interacts with Smad2 or Smad3, and that this interaction is mediated by specific domains of the two interacting molecules, namely, the MH2 domain of Smad2 or Smad3 and the Smad Interaction Domain (SID) of FAST-1. This result allows the development of methods and reagents for the isolation of compounds that are involved in, and/or modulate, TGF- superfamily signalling.

US Patent:

7700594, Apr 20, 2010

Filed:

Nov 15, 2006

Appl. No.:

11/599663

Inventors:

Xin Chen - Farmingdale NY, US
Heather Coate - Farmingdale NY, US
Andrew Philip Crew - Farmingdale NY, US
Ayako Honda - Farmingdale NY, US
Mark Joseph Mulvihill - Farmingdale NY, US
Paula A. R. Tavares - Farmingdale NY, US
Jing Wang - Farmingdale NY, US
Douglas S. Werner - Farmingdale NY, US
Kristen Michelle Mulvihill - Farmingdale NY, US
Kam W. Siu - Farmingdale NY, US
Bijoy Panicker - Farmingdale NY, US
Apoorba Bharadwaj - Farmingdale NY, US
Lee D. Arnold - Farmingdale NY, US
Meizhong Jin - Farmingdale NY, US
Brian Volk - Farmingdale NY, US
Qinghua Weng - Farmingdale NY, US
James David Beard - Farmingdale NY, US

Assignee:

OSI Pharmaceuticals, Inc. - Melville NY

International Classification:

C07D 487/04
C07D 401/14
C07D 403/04
A61K 31/53
A61K 31/4523
A61K 35/00

US Classification:

514243, 544184

Abstract:

Compounds represented by Formula (I).

US Patent:

8111957, Feb 7, 2012

Filed:

Jul 7, 2009

Appl. No.:

12/498591

Inventors:

Robert R Alfano - Bronx NY, US
Xin Chen - Corning NY, US
Joohyun Koh - Painted Post NY, US
Ming-Jun Li - Horseheads NY, US
Daniel Aloysius Nolan - Corning NY, US
Henry Sztul - New York NY, US

Assignee:

Corning Incorporated - Corning NY

International Classification:

G02B 6/26
G01N 21/00

US Classification:

385 28, 356 731

Abstract:

Generation of a cylindrically polarized light beam, and in particular, a hybrid-azimuthal-radial polarization beams, called HARP modes, generated from an input linearly polarized Gaussian beam using a spun optical waveguide device is taught. The HARP modes are comprised of hybrid-azimuthal polarization (HAP) and hybrid-radial polarization (HRP) superposition modes. These beams possess a non-zero local angular momentum density that is spatially varying and a zero total angular momentum.

US Patent:

8138363, Mar 20, 2012

Filed:

Nov 2, 2007

Appl. No.:

12/312293

Inventors:

Xin Chen - Hockessin DE, US
Howard W. Prokop - Chadds Ford PA, US
Stephen Howard Colmery - Newark DE, US

Assignee:

Uniqema Americas LLC - Wilmington DE

International Classification:

C07C 231/00

US Classification:

554 69

Abstract:

The present invention relates to a process for the manufacture of alkanolamide containing compositions, and more particularly to a process of reacting a fatty acid and diethanolamine (DEA) which result in the formation of low levels of undesirable by products, particularly of bis-hydroxyethyl piperazine (BHEP).

US Patent:

20020160355, Oct 31, 2002

Filed:

Jan 11, 2002

Appl. No.:

10/044442

Inventors:

Malcolm Whitman - Boston MA, US
Xin Chen - Mountain View CA, US

International Classification:

C12Q001/00
C12Q001/68

US Classification:

435/004000, 435/006000

Abstract:

FAST-and Smad2 or Smad3 form a complex that is specifically induced by signals generated by a TGF- superfamily member. We have shown that a domain of FAST-directly interacts with Smad2 or Smad3, and that this interaction is mediated by specific domains of the two interacting molecules, namely, the MH2 domain of Smad2 or Smad3 and the Smad Interaction Domain (SID) of FAST-. This result allows the development of methods and reagents for the isolation of compounds that are involved in, and/or modulate, TGF- superfamily signalling.

US Patent:

20070208053, Sep 6, 2007

Filed:

Jan 18, 2007

Appl. No.:

11/654814

Inventors:

Lee Arnold - Farmingdale NY, US
Xin Chen - Farmingdale NY, US
Hanqing Dong - Farmingdale NY, US
Andrew Garton - Farmingdale NY, US
Mark Mulvihill - Farmingdale NY, US
Colin Sambrook Smith - Oxford, GB
Gerard Thomas - Oxford, GB
Thomas Krulle - Oxford, GB
Jing Wang - Farmingdale NY, US

International Classification:

C07D 471/02
A61K 31/4745

US Classification:

514300000, 546113000

Abstract:

Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X, X, X, X, X, X, X, R, and Qare defined herein, inhibit kinase enzymes and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer. The compounds are also useful in the treatment of inflammation, allergy, asthma, disease and conditions of the immune system, disease and conditions of the nervous system, cardiovascular diseases, disease and conditions of the eye, dermatological diseases, osteoporosis, diabetes, multiple sclerosis, and infections.

US Patent:

20120181184, Jul 19, 2012

Filed:

Mar 8, 2010

Appl. No.:

13/254967

Inventors:

George M. Whitesides - Newton MA, US
Zhihong Nie - Cambridge MA, US
Christian Nijhuis - Somerville MA, US
Xin Chen - Cambridge MA, US
Andres W. Martinez - Cambridge MA, US
Max Narovlyansky - Cambridge MA, US

Assignee:

PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA

International Classification:

G01N 27/26
G01N 27/416

US Classification:

205775, 204400, 204412

Abstract:

Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fluidic communication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a reference electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of assembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described.

US Patent:

20120272642, Nov 1, 2012

Filed:

Mar 15, 2012

Appl. No.:

13/420886

Inventors:

Cagdas Denizel Onal - Cambridge MA, US
Daniela Rus - Weston MA, US
Xin Chen - Cambridge MA, US
George M. Whitesides - Newton MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA
Massachusetts Institute of Technology - Cambridge MA

International Classification:

F15B 13/16
B01J 19/00

US Classification:

60409, 422129, 422187

Abstract:

Self-regulating pressure source. The pressure source includes a chamber enclosing a chemical monopropellant. A moveable boss is attached to a deformable membrane sealing an air chamber, the moveable boss and air chamber being disposed within the chamber. A catalyst is disposed around the membrane so as to be covered by the boss in a retracted position so that the monopropellant is broken down by the catalyst to produce a gas. The gas pressure will increase within the chamber causing air in the air chamber to compress thereby to pull the boss into the retracted position to cover the catalyst thereby to regulate the pressure within the chamber. The self-regulating pressure source is particularly suited to power fluidic elastomeric actuators.