Xin Wang

US Patent:

8143299, Mar 27, 2012

Filed:

Oct 25, 2005

Appl. No.:

11/577953

Inventors:

William J. Welsh - Princeton NJ, US
Youyi Peng - Piscataway NJ, US
Xin Wang - Piscataway NJ, US
Susan M. Keenan - Longmont CO, US
Qiang Zhang - Piscataway NJ, US
Sonia Arora - Franklin Park NJ, US

Assignee:

University of Medicine and Dentistry of New Jersey - Somerset NJ

International Classification:

A61K 31/4196
C07D 249/08

US Classification:

514383, 548255, 5482622

Abstract:

Substituted triazole compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a pathology linked to a hyperproliferative disorder by administering the substituted triazole compounds to a patient in need thereof.

US Patent:

8304719, Nov 6, 2012

Filed:

Feb 20, 2010

Appl. No.:

12/709474

Inventors:

Xin Wang - Princeton NJ, US
Haiying Zhang - Princeton NJ, US

International Classification:

H01J 49/00

US Classification:

250288, 250281, 250282

Abstract:

A method for identifying and characterizing components of interest in complex samples includes subjecting both a sample and its control samples to chromatography/high resolution mass spectrometry analysis to detect ions of the samples. The method includes defining sections of control sample data within specified chromatographic fluctuation time and mass precision windows around each ion or each group of the same ions of question in the test sample data. The defined sections of the control sample data are examined and the maximal intensities are subtracted from respective ions in the test sample. Components of interest are determined from the resultant data of the test sample. The method can be used for identifying molecular ions and/or their fragment ions for components of interest in complex samples.

US Patent:

8569350, Oct 29, 2013

Filed:

Feb 23, 2012

Appl. No.:

13/403617

Inventors:

William J. Welsh - Princeton NJ, US
Youyi Peng - Somerset NJ, US
Xin Wang - Piscataway NJ, US
Susan M. Keenan - Longmont CO, US
Qiang Zhang - Piscataway NJ, US
Sonia Arora - Franklin Park NJ, US

Assignee:

Rutgers, The State University of New Jersey - New Brunswick NJ

International Classification:

A61K 31/4196
C07D 249/08

US Classification:

514383, 548255, 5482622, 514359

Abstract:

Substituted triazole compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a pathology linked to a hyperproliferative disorder by administering the substituted triazole compounds to a patient in need thereof.

US Patent:

20040116371, Jun 17, 2004

Filed:

Sep 29, 2003

Appl. No.:

10/675226

Inventors:

Tony Romeo - Decatur GA, US
Xin Wang - Atlanta GA, US

International Classification:

A61K048/00

US Classification:

514/044000

Abstract:

There is provided a method for modulation of polysaccharide adhesin synthesis involving products of the ycdSRQP gene operon in bacteria, depicted in SEQ. ID. NO. 1 and 2. Also provided is the use of an inhibitor of a product of the ycdSRQP operon in improving the response of a mammalian patient suffering from a bacterial infection.

US Patent:

20040171517, Sep 2, 2004

Filed:

Sep 29, 2003

Appl. No.:

10/675738

Inventors:

Tony Romeo - Decatur GA, US
Xin Wang - Atlanta GA, US
Kazushi Suzuki - Decatur GA, US

International Classification:

A61K038/00
C12N001/21

US Classification:

514/002000, 435/252330

Abstract:

There is provided a method of reducing biofilm formation by biofilm-forming bacterial strains such as Salmonella, Klebsiella, or a related gamma proteobacteria. CsrA activity levels in the cell may be modulated to impact biofilm formation and glycogen metabolism. CsrA levels may be modulated by modulating the expression of csrB RNA and UvrY and BarA gene products. By increasing levels of CsrB, BarA or SdiA in a bacterial cell or increasing the rate of UvrY phosphorylation, one can increase the levels of active UvrY in the strain. There is also provided a modulator of CsrA activity in a bacteria comprising a nucleotide sequence containing the sequence element CAGGAUG.

US Patent:

20050032093, Feb 10, 2005

Filed:

Apr 16, 2004

Appl. No.:

10/826967

Inventors:

Tony Romeo - Decatur GA, US
Xin Wang - Atlanta GA, US
Rebecca Desplas - Dallas TX, US

International Classification:

C12Q001/68

US Classification:

435006000

Abstract:

The present invention relates to biofilm genes, their polypeptides, and the use of such genes, polypeptides and control regions in determining compositions for use in the disruption of biofilms and the treatment of disease. The identified compositions regulate the expression of the biofilm genes or modulate the activity of their protein products.

US Patent:

20070097957, May 3, 2007

Filed:

Oct 31, 2005

Appl. No.:

11/264230

Inventors:

Binshi Cao - Bridgewater NJ, US
Xin Wang - Parsippany NJ, US
Yang Yang - Parsippany NJ, US

Assignee:

Lucent Technologies Inc. - Murray Hill NJ

International Classification:

H04L 12/66

US Classification:

370352000

Abstract:

A method for gracefully degrading packet data voice quality in a wireless network includes monitoring and evaluating data transfer conditions on the network. This may be done on a network-wide level, or for access terminals individually. For the evaluation, data transfer conditions are compared to criteria that indicate a relative quality level. Based on the evaluation, a variable number of the voice data packets addressed to the access terminals are eliminated prior to transmission over the airlink. If conditions are optimal, no data packets are eliminated. If not, one or more packets may be eliminated periodically (e.g., 1 data packet out of every five) until conditions change. The access terminals compensate for any eliminated packets. In this manner, packet data voice quality is gracefully degraded for temporarily reducing voice traffic on the network when conditions are poor, avoiding the need for dropped calls or the like.

US Patent:

20090118310, May 7, 2009

Filed:

Aug 9, 2006

Appl. No.:

11/463535

Inventors:

Alam Nur-E-Kamal - Edison NJ, US
Ailing Zhang - Dayton NJ, US
William J. Welsh - Princeton NJ, US
Susan M. Keenan - Franklin Park NJ, US
Xin I. Wang - Piscataway NJ, US

Assignee:

UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY - New Brunswick NJ

International Classification:

A61K 31/519
A61P 35/00

US Classification:

51426411

Abstract:

Methods for preventing or treating Ras-induced cancer in a patient by (a) detecting v-Ha-Ras-transformed cells in a patient and (b) administering to the patient a therapeutically effective amount of a chemotherapeutic composition comprising an effective amount of an inhibitor for activated Cdc42-associated kinase (ACK) kinase.