- Baltimore MD, US David Gracias - Baltimore MD, US Jayson Pagaduan - Windsor MD, US Anil Bhatta - Baltimore MD, US Xing Chen - Baltimore MD, US Qianru Jin - Cambridge MA, US
International Classification:
G01N 33/50 C12N 5/077 C12N 5/071 B01L 3/00
Abstract:
In one aspect, provided is a composition (biomimetic composition) that includes a biomimetic in vitro model of an arteriolar vessel comprising: at least one of 1) human smooth muscle cells and 2) human pulmonary endothelial cells; wherein the vessel recapitulates one or more of the overall tubular geometry, morphometrics, extracellular matrix constituents, cellular morphology, cellular alignment, and functional heterotypic connections between the human smooth muscle cells and/or the human endothelial cells as compared to an in vivo arteriolar vessel. A microfluidics-based model platform of the pulmonary circulation is provided. Methods of use include measuring flow in biomimetic vessels, and to determine the resistance of these biomimetic vessels in the setting of a variety of experimental conditions that recapitulate the pathobiology of pulmonary hypertension.
2011 to 2000 Senior Analyst Schedule PlanningFEDERAL AVIATION ADMINSTRATION (FAA) Washington, DC 2006 to 2011 Operation Research AnalystNATIONAL CENTER OF EXCELLENCE FOR AVIATION OPERATIONS RESEARCH (NEXTOR) Berkeley, CA 2005 to 2006 Graduate Research Assistant
Education:
NEW YORK UNIVERSITY New York, NY Jan 2015 Master of Business Administration in SpecializationsUNIVERSITY OF CALIFORNIA, BERKELEY Berkeley, CA Jun 2014UC Berkeley 2001
Department of Statistics, George Washington University
Sep 2012 to 2000 Teaching AssistantDepartment of Statistics, George Washington University Washington, DC May 2014 to Present Research ConsultantCenter for International Business and Education Research
Feb 2011 to Dec 2011 Research AssistantWelcome Center of International Student Office, George Washington University
Sep 2011 to Nov 2011 VolunteerMarketing Department, Gilbarco/China Company
Mar 2010 to May 2010 Marketing InternChina National Statistics Bureau
Jun 2009 to Aug 2009 InternSchool
Sep 2007 to Jun 2009 Basketball and Soccer Team MemberBeijing Olympic Game
Jun 2008 to Aug 2008 VolunteerPress Department of Student Association
Sep 2007 to Jun 2008 Head
Education:
George Washington University Washington, DC Sep 2012 to 2000 Ph. D in StatisticsGeorge Washington University Washington, DC May 2012 M.S. in StatisticsCapital University of Economics and Business May 2010 B.S. in Statistics