Xing H Wang

US Patent:

7449582, Nov 11, 2008

Filed:

Oct 8, 2004

Appl. No.:

10/961646

Inventors:

Qiang Ding - San Diego CA, US
Yongping Xie - San Diego CA, US
Nathanael S. Gray - San Diego CA, US
Shuli You - San Diego CA, US
Greg Chopiuk - San Diego CA, US
Jiqing Jiang - San Diego CA, US
Yi Liu - San Diego CA, US
Ruo Steensma - La Jolla CA, US
Xing Wang - San Diego CA, US
Taebo Sim - San Diego CA, US

Assignee:

IRM LLC - Hamilton

International Classification:

C07D 215/38
C07D 471/02
C07D 251/38

US Classification:

546153, 546157, 546123, 544224, 5142641, 514299

Abstract:

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, CSK, JNK1, JNK2, PDGF-R, p38, p70S6K, TGFβ, SRC, EGFR, c-Kit, trkB, FGFR3, Fes, Lck, Syk, RAF, MKK4, MKK6 and SAPK2β kinases.

US Patent:

7750032, Jul 6, 2010

Filed:

Feb 3, 2006

Appl. No.:

11/815096

Inventors:

Christopher Cow - San Diego CA, US
Robert Epple - San Diego CA, US
Xing Wang - San Diego CA, US
Yongping Xie - San Diego CA, US
Hans Martin Seidel - Del Mar CA, US

Assignee:

IRM LLC - Hamilton

International Classification:

C07D 213/64
C07D 265/30
C07D 233/64
C07D 231/12
C07D 413/10
C07D 401/04
A61K 31/4155
A61K 31/4178
A61K 31/4164
A61K 31/4439
A61K 31/5377

US Classification:

514400, 5142385, 5142365, 514341, 514406, 5483425, 5483761, 5462741, 5462754, 544139

Abstract:

The invention provides trisubstituted pyrazoles and imidazoles of Formula I:.

US Patent:

7868018, Jan 11, 2011

Filed:

Aug 9, 2006

Appl. No.:

11/997113

Inventors:

Yongping Xie - San Diego CA, US
Guobao Zhang - San Diego CA, US
Xing Wang - San Diego CA, US
Nathanael S. Gray - Boston MA, US
Yi Liu - San Diego CA, US

Assignee:

IRM LLC - Hamilton

International Classification:

C07D 471/04
A61K 31/4375
A61P 35/00
A61P 37/00
A61P 25/00
A61K 31/519
C07D 413/12
A61K 31/5355
A61K 31/4355
C07D 491/147

US Classification:

514300, 546122, 546 83, 544279, 544117, 5142641, 51426411, 5142342, 514293

Abstract:

The invention provides compounds of Formula I:wherein R-Rare described in the Summary of the Invention; the pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, BMX, BTK, CHK2, b-RAF, c-RAF, CSK, c-SRC, Fes, FGFR3, Flt3, IKKα, IKKβ, JNK2α2, Lck, Met, MKK4, MKK6, MST2, NEK2, p70S6K, PDGFRβ, PKA, PKBα, PKD2, Rsk1, SAPK2α, SAPK2β, SAPK3, SGK, Tie2 and TrkB kinases.

US Patent:

8202876, Jun 19, 2012

Filed:

Sep 24, 2007

Appl. No.:

12/444129

Inventors:

Pamela Albaugh - Carlsbad CA, US
Gregory B. Chopiuk - San Diego CA, US
Qiang Ding - San Diego CA, US
Shenlin Huang - San Diego CA, US
Zuosheng Liu - San Diego CA, US
Shifeng Pan - San Diego CA, US
Pingda Ren - San Diego CA, US
Xia Wang - San Diego CA, US
Xing Wang - San Diego CA, US
Yongping Xie - San Diego CA, US
Chengzhi Zhang - San Diego CA, US
Qiong Zhang - Union City CA, US
Guobao Zhang - San Diego CA, US
Daniel Poon - Oakland CA, US
Paul Renhowe - Danville CA, US
Martin Sendzik - San Mateo CA, US

Assignee:

IRM LLC - Hamilton
Novartis AG - Basel

International Classification:

C07D 401/00
C07D 403/00
C07D 405/00
C07D 409/00
C07D 411/00
C07D 413/00
C07D 417/00
C07D 419/00
C07D 231/00
C07D 403/02
A01N 43/56
A61K 31/415

US Classification:

514256, 514406, 544333, 5483641

Abstract:

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, ARG, BCR-Abl, BRK, EphB, Fms, Fyn, KDR, c-Kit, LCK, PDGF-R, b-Raf, c-Raf, SAPK2, Src, Tie2 and TrkB kinases.

US Patent:

8431607, Apr 30, 2013

Filed:

Dec 12, 2007

Appl. No.:

12/519147

Inventors:

Hong Liu - San Diego CA, US
Xiaohui He - San Diego CA, US
Dean Phillips - San Marcos CA, US
Xuefeng Zhu - Carlsbad CA, US
Kunyong Yang - San Diego CA, US
Thomas Lau - San Diego CA, US
Baogen Wu - San Diego CA, US
Yongping Xie - San Diego CA, US
Truc Ngoc Nguyen - San Diego CA, US
Xing Wang - San Diego CA, US

Assignee:

IRM LLC, A Delaware Limited Liability Company - Hamilton

International Classification:

A01N 43/50
A61K 31/415
A61K 31/50
A61K 31/501
A61K 31/497
C07D 401/00
C07D 233/00
C07D 233/02
C07D 241/00
C07D 241/02

US Classification:

514391, 514390, 5142521, 5462727, 5483001, 544336

Abstract:

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).

US Patent:

8501758, Aug 6, 2013

Filed:

Aug 27, 2010

Appl. No.:

12/870130

Inventors:

Shenlin Huang - San Diego CA, US
Xianming Jin - San Ramon CA, US
Zuosheng Liu - San Diego CA, US
Daniel Poon - Piedmont CA, US
John Tellew - La Jolla CA, US
Yongqin Wan - San Diego CA, US
Xing Wang - San Diego CA, US
Yongping Xie - San Diego CA, US

Assignee:

IRM LLC - Hamilton
Novartis AG - Basel

International Classification:

A01N 43/54

US Classification:

514275, 544331

Abstract:

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

US Patent:

20070203155, Aug 30, 2007

Filed:

May 24, 2005

Appl. No.:

11/597282

Inventors:

Robert Epple - San Diego CA, US
Christopher Cow - San Diego CA, US
Yongping Xie - San Diego CA, US
Xing Wang - San Diego CA, US
Ross Russo - San Diego CA, US
Mihai Azimioara - La Jolla CA, US
Enrique Saez - San Diego CA, US

Assignee:

IRM LLC - Hamilton

International Classification:

A61K 31/506
A61K 31/4709
A61K 31/4439
A61K 31/426
A61K 31/427
C07D 417/02

US Classification:

514256000, 514314000, 514366000, 514365000, 514369000, 514342000, 544333000, 546169000, 546269700, 548181000

Abstract:

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR.

US Patent:

20070244130, Oct 18, 2007

Filed:

May 24, 2005

Appl. No.:

11/597260

Inventors:

Robert Epple - San Diego CA, US
Yongping Xie - San Diego CA, US
Xing Wang - San Diego CA, US
Christopher Cow - San Diego CA, US
Ross Russo - Encinitas CA, US

Assignee:

IRM LLC - Hamilton

International Classification:

A01N 43/54
A61K 31/42
A61K 31/435
C07D 263/30
C07D 401/00
C07D 411/00

US Classification:

514256000, 514340000, 514374000, 544333000, 546269400, 548235000

Abstract:

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR.