Xing P Wang

US Patent:

20190194315, Jun 27, 2019

Filed:

Jun 17, 2016

Appl. No.:

15/737042

Inventors:

Tinya ABRAMS - Acton MA, US
Steven Bruce COHEN - San Diego CA, US
Joseph Anthony D'Alessio - Boston MA, US
Jason Damiano - Oakland CA, US
Clemens Durr - Weil am Rhein, DE
Bernhard Hubert GEIERSTANGER - Solana Beach CA, US
Thomas HUBER - Basel, CH
Hidetomo IMASE - Somerville MA, US
Yunho JIN - San Diego CA, US
Daniel MENEZES - Berkeley CA, US
Kathy MILLER - San Francisco CA, US
Morvarid MOHSENI - Boston MA, US
Weijia OU - San Diego CA, US
Katherine RENDAHL - Berkeley CA, US
Tetsuo UNO - San Diego CA, US
Yongqin WAN - San Diego CA, US
Xing WANG - San Diego CA, US

Assignee:

Novartis AG - Basel

International Classification:

C07K 16/28
A61K 47/65
A61K 47/68
A61P 35/00
A61K 38/07

Abstract:

This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments, particularly antibody drug conjugates comprising anti-P-cadherin antibodies conjugated to auristatin analogs. The invention also relates to methods of treating cancer using the antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.