Xingguo G Cheng from Cary, NC, age 51

Us Patents

Aligned Collagen And Method Therefor
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US Patent:

20100311949, Dec 9, 2010
Filed:

Nov 26, 2008
Appl. No.:

12/745362
Inventors:

Ozan Akkus - West Lafayette IN, US
Alyssa Panitch - West Lafayette IN, US
Xingguo Cheng - San Antonio TX, US
Assignee:

PURDUE RESEARCH FOUNDATION - West Lafayette IN
International Classification:

C07K 14/78
US Classification:

530356
Abstract:

Compositions and methods of preparing a graft construct comprising aligned collagen fibrils, wherein the construct is anisotropic, are described. The construct is prepared by application of an electrochemical field and a pH gradient to solutions containing collagen. In accordance with this method, collagen aligns at its isoelectric point to form anisotropic constructs.

Coating For Medical Implants
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US Patent:

20110217351, Sep 8, 2011
Filed:

Mar 4, 2010
Appl. No.:

12/717666
Inventors:

Xingguo CHENG - San Antonio TX, US
Nitin NITIN - Vacaville CA, US
Jorge G. ROSSINI - San Antonio TX, US
Stephen T. WELLINGHOFF - San Antonio TX, US
Assignee:

SOUTHWEST RESEARCH INSTITUTE - San Antonio TX
International Classification:

B05D 1/36
A61F 2/02
US Classification:

424423, 427 224
Abstract:

A medical implant for drug delivery comprising an inner layer of polymer material including a drug dispersed therein and an outer layer which may then mediate the release of the drug in a controllable manner. The outer layer may adhere and/or penetrate the underlying layer and offer a protective coating along with improved mechanical strength along with the ability to hydrate and become permeable to water and allow for drug release.

Aligned Polymers Including Bonded Substrates
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US Patent:

20110306754, Dec 15, 2011
Filed:

Jun 11, 2010
Appl. No.:

12/813834
Inventors:

Xingguo Cheng - San Antonio TX, US
Vasiliki Z. Poenitzsch - Alamo Heights TX, US
Assignee:

SOUTHWEST RESEARCH INSTITUTE - San Antonio TX
International Classification:

C07K 14/78
C25B 1/00
US Classification:

530356, 205555, 977750, 977752
Abstract:

The present disclosure relates to the present disclosure relates to a method of fabricating an aligned polymer containing a bonded substrate and related compositions. The method involved placing a polymer in solution which is capable of alignment wherein the polymer is also bound to a selected substrate. This may then be followed by placing the polymer solution in an electrochemical cell wherein the polymer solution is in contact with at least one electrode and applying an electric field/voltage to the polymer solution and generating a pH gradient wherein the polymer and bonded substrate positions at the isoelectric point of the polymer in solution.

Magnetic Calcium Phosphate Nanoparticles, Applications And Methods Of Preparation Thereof
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US Patent:

20140044643, Feb 13, 2014
Filed:

Aug 7, 2012
Appl. No.:

13/568644
Inventors:

Xingguo CHENG - San Antonio TX, US
Qingwen Ni - San Antonio TX, US
Thomas B. POTTER - Sugar Land TX, US
Assignee:

Southwest Research Institute - San Antonio TX
International Classification:

A61K 33/42
A61K 49/00
G01N 33/53
US Classification:

424 91, 424602, 436501
Abstract:

Magnetic calcium phosphate particles are provided including particles comprising iron oxide and calcium phosphate. A chitosan coating is present on the particles, wherein the particles are less than or equal to 1,000 nm, are magnetic and exhibit a positive charge in the range of 1 mVolts to 60 mVolts. The particles are provided by preparing a calcium hydroxide solution and filtering the calcium hydroxide solution in a membrane filter. An iron chloride solution is formed and combined with the filtered calcium hydroxide solution. In addition, the phosphoric acid solution is combined with the combined solutions of iron chloride and calcium hydroxide, forming a mixture including particles comprising iron oxide and calcium phosphate.

Fabrication Of Bone Regeneration Scaffolds And Bone Filler Material Using A Perfusion Flow System
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US Patent:

20150343117, Dec 3, 2015
Filed:

Jun 2, 2015
Appl. No.:

14/728336
Inventors:

- San Antonio TX, US
Ben ANTEBI - Helotes TX, US
Xingguo CHENG - San Antonio TX, US
Jeffrey N. HARRIS - San Antonio TX, US
Xiao-Dong Chen - San Antonio TX, US
International Classification:

A61L 27/46
A61L 27/54
A61L 27/38
Abstract:

The present disclosure is directed at a process to form bone grafting material. One may provide a porous collagen scaffold and insert the scaffold into a perfusion chamber of a perfusion flow system. This may then be followed by continuously providing a mineralization perfusion fluid flow through the scaffold at a flow rate to provide dynamic intrafibrillar mineralization of the scaffold and form a collagen/hydroxyapatite composite scaffold. One may optionally provide the scaffold with bone tissue forming cells and then deliver a perfusion fluid including oxygen and one or more nutrients through the collagen/hydroxyapatite composite scaffold and to the bone tissue forming cells at a flow rate such that the bone tissue forming cells remodel the collagen/hydroxyapatite composite scaffold and form a bone tissue extracellular matrix. The bone tissue extracellular matrix may then be decellularized to form an acellular bone repair scaffold.

Hybrid Tissue Scaffold For Tissue Engineering
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US Patent:

20150050736, Feb 19, 2015
Filed:

Aug 25, 2014
Appl. No.:

14/467879
Inventors:

- San Antonio TX, US
Jian LING - Spring Branch TX, US
Xingguo CHENG - San Antonio TX, US
International Classification:

C12N 5/00
US Classification:

435396, 435395
Abstract:

A hybrid tissue scaffold is provided which comprises a porous primary scaffold having a plurality of pores and a porous secondary scaffold having a plurality of pores, wherein the secondary scaffold resides in the pores of the primary scaffold to provide a hybrid scaffold. The pores of the porous primary scaffold may have a pore size in a range of 0.50 mm to 5.0 mm, and the pores of the porous secondary scaffold may have a pore size in a range of 50 μm to 600 μm. The primary scaffold may provide 5% to 30% of a volume of the hybrid scaffold.

Fabrication Of Bone Regeneration Scaffolds And Bone Filler Material Using A Perfusion Flow System
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US Patent:

20140170117, Jun 19, 2014
Filed:

Dec 19, 2012
Appl. No.:

13/720543
Inventors:

- San Antonio TX, US
Ben ANTEBI - McKinney TX, US
Xingguo CHENG - San Antonio TX, US
Jeffrey N. HARRIS - San Antonio TX, US
Assignee:

SOUTHWEST RESEARCH INSTITUTE - San Antonio TX
International Classification:

A61L 27/46
US Classification:

424 937, 514 167
Abstract:

The present disclosure is directed at a process to form bone grafting material. One may provide a porous collagen scaffold and insert the scaffold into a perfusion chamber of a perfusion flow system. This may then be followed by continuously providing a mineralization perfusion fluid flow through the scaffold at a flow rate to provide dynamic intrafibrillar mineralization of the scaffold and form a collagen/hydroxyapatite composite scaffold. One may optionally provide the scaffold with bone tissue forming cells and then deliver a perfusion fluid including oxygen and one or more nutrients through the collagen/hydroxyapatite composite scaffold and to the bone tissue forming cells at a flow rate such that the bone tissue forming cells remodel the collagen/hydroxyapatite composite scaffold and form a bone tissue extracellular matrix. The bone tissue extracellular matrix may then be decellularized to form an acellular bone repair scaffold.

Hybrid Tissue Scaffold For Tissue Engineering
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US Patent:

20140161841, Jun 12, 2014
Filed:

Dec 12, 2012
Appl. No.:

13/712583
Inventors:

- San Antonio TX, US
Jian LING - Spring Branch TX, US
Xingguo CHENG - San Antonio TX, US
Assignee:

SOUTHWEST RESEARCH INSTITUTE - San Antonio TX
International Classification:

A61L 31/14
US Classification:

424400, 424 931
Abstract:

A hybrid tissue scaffold is provided which comprises a porous primary scaffold having a plurality of pores and a porous secondary scaffold having a plurality of pores, wherein the secondary scaffold resides in the pores of the primary scaffold to provide a hybrid scaffold. The pores of the porous primary scaffold may have a pore size in a range of 0.50 mm to 5.0 mm, and the pores of the porous secondary scaffold may have a pore size in a range of 50 μm to 600 μm. The primary scaffold may provide 5% to 30% of a volume of the hybrid scaffold.