Xiuyuan Hu

US Patent:

20070087984, Apr 19, 2007

Filed:

Aug 24, 2004

Appl. No.:

10/570911

Inventors:

Xiuyuan Hu - San Diego CA, US
Henry Li - Carlsbad CA, US
Ning Ke - San Diego CA, US
Mirta Grifman - San Diego CA, US
Cheryl Rogers - San Diego CA, US
Kristen Difife - San Diego CA, US
Cellia Habita - La Jolla CA, US
Wufang Fan - San Diego CA, US
Kristina Rhoades - Crowley TX, US
Philip Tan - San Diego CA, US
Richard Tritz - San Diego CA, US
Flossie Wong-Staal - San Diego CA, US

International Classification:

A61K 48/00

US Classification:

514044000

Abstract:

The present invention is directed to methods of identifying agents useful for inhibiting cancer cells. The agents bind to one of the proteins described herein, or to a gene or mRNA encoding such protein. The invention is also directed to methods for inhibiting cancer cells by administering an agent that binds to one of the proteins described herein, or to a gene or mRNA encoding such protein.

US Patent:

20070184459, Aug 9, 2007

Filed:

Feb 3, 2006

Appl. No.:

11/351522

Inventors:

Henry Li - Carlsbad CA, US
Ning Ke - San Diego CA, US
Mirta Grifman - San Diego CA, US
Gisela Claasen - San Diego CA, US
Xiuyuan Hu - San Diego CA, US
Kristen Defife - San Diego CA, US
Cellia Habita - La Jolla CA, US
Wufang Fan - San Diego CA, US
Kristina Rhoades - Crowley TX, US
Philip Tan - San Diego CA, US
Flossie Wong-Staal - San Diego CA, US

International Classification:

C12Q 1/68
G01N 33/574
C12N 15/09

US Classification:

435006000, 435007230, 435455000

Abstract:

The present invention provides methods for identifying agents useful for inhibiting cancer cells by binding to various nuclear receptor proteins, or to the genes or RNA encoding such proteins.

US Patent:

20020037507, Mar 28, 2002

Filed:

Dec 14, 2000

Appl. No.:

09/736863

Inventors:

Cindy WalkerPeach - Austin TX, US
Xiuyuan Hu - San Diego CA, US

International Classification:

C12Q001/68
C12P019/34
C07H021/04

US Classification:

435/006000, 435/091100, 536/024300

Abstract:

The invention relates to sequence-specific polynucleotide probes, pairs of probes, the design of pairs of probes in relation to the strands of target nucleic acid, and coordinate sequence-specific pairs of polynucleotide primers, and also relates to kits containing such probes, probe pairs, primers, and primer pairs. The invention thus relates to kits and methods employing such polynucleotides. The invention relates to six specific allele discrimination kits. The specific kits are developed for the detection of four single base substitutions in the human CCR2, SDF1, Factor V, MTHFR, Factor XIII genes, and a 32-bp deletion in the human CCR5 gene. The capability of using two allele-specific molecular beacons in the same PCR solution enables the simultaneous determination of three possible allelic representations of a given sequence change in target DNA (Allele 1/Allele 1, Allele 2/Allele 2, Allele 1/Allele 2). It also definitively differentiates a true negative signal that is due to the absence of an allele from a false negative signal that results from PCR failure.