Xuejun K Liu

US Patent:

20100087636, Apr 8, 2010

Filed:

Mar 13, 2008

Appl. No.:

12/450094

Inventors:

Paul Bruzinski - Clifton Park NY, US
Xuejun Liu - Arcadia CA, US
Cameron Gibb - Delmar NY, US
Pedro E. Hernandez-Abad - Arroyo PR, US

International Classification:

C07H 19/16
C07H 1/00

US Classification:

536 276, 536 553

Abstract:

The present disclosure provides a method for the synthesis of IB-MECA. More specifically, the present disclosure provides a simple and high yield method for Good Manufacturing Production (GMP) of IB-MECA. The method involves the reaction of 6-halopurine-9-riboside with a diol protecting reagent; oxidation of the primary alcohol in the diol protected 6-halopurine-9-riboside with a diol protecting reagent; oxidation of the primary alcohol in the diol protected 6-halopurine; reaction of the diol protected 6-halopurine with a nucleophile (e.g. methylamine); substitution of the halogen group with iodobenzylamine and removal of the diol protecting group.

US Patent:

20130280768, Oct 24, 2013

Filed:

Sep 1, 2011

Appl. No.:

13/819985

Inventors:

Ramanaiah C. Kanamarlapudi - Bridgewater NJ, US
Steven A. Weissman - Short Hills NJ, US
Emerich Eisenreich - Claremont CA, US
Xuejun Liu - Arcadia CA, US

Assignee:

CONCERT PHARMACEUTICALS, INC. - Lexington MA

International Classification:

C12P 17/18

US Classification:

435119

Abstract:

The present invention provides a process for the preparation of enantiomerically enriched, deuterated secondary alcohols of Formula 1-A by employing ketoreductases or carbonyl reductases without reducing deuterium incorporation.

US Patent:

20140017739, Jan 16, 2014

Filed:

Sep 1, 2011

Appl. No.:

13/820003

Inventors:

Ramanaiah C. Kanamarlapudi - Bridgewater NJ, US
Steven A. Weissman - Short Hills NJ, US
Emerich Eisenreich - Claremont CA, US
Xuejun Liu - Arcadia CA, US

Assignee:

CONCERT PHARMACEUTICALS, INC. - Lexington MA

International Classification:

C12P 17/18

US Classification:

435119

Abstract:

The present invention provides a convenient and efficient process for the preparation of enantiomerically enriched, deuterated secondary alcohols without reducing deuterium incorporation.

US Patent:

20210276942, Sep 9, 2021

Filed:

Feb 11, 2019

Appl. No.:

16/967627

Inventors:

- South San Francisco CA, US
Peter LEEMING - Monrovi CA, US
Emerich EISENREICH - Claremont CA, US
Xuejun Karl LIU - Arcadia CA, US

International Classification:

C07C 227/18
C07C 227/32
C07C 227/16
C07C 269/06
C07C 271/22
C07C 229/36
C07C 227/40

Abstract:

The invention relates to an overall enantio-specific synthesis of 4-chlorokynurenine compounds, in particular L-4-chlorokynurenine, with improved yields. Large-scale syntheses are disclosed. The invention also relates to novel intermediates in the synthesis of L-4-chlorokynurenine.

US Patent:

20180179156, Jun 28, 2018

Filed:

Jun 6, 2016

Appl. No.:

15/736662

Inventors:

- Canandaigua NY, US
Emerich Eisenreich - Claremont CA, US
Xuejun Karl Liu - Arcadia CA, US
Bingidimi Itute Mobele - Altamont NY, US
Satish Goud Puppali - Rancho Cucamonga CA, US

International Classification:

C07D 207/12
C07C 53/126
C07C 57/12
C07C 57/03

Abstract:

Novel glycopyrronium fatty acid salts have been developed. Bi-phasic reaction conditions enable the desired counterion exchange reactions between glycopyrronium bromide and fatty acid salts of alkali metals and alkaline earth metals in methods to form glycopyrronium fatty acid salts. In preferred embodiments, an excess of the free fatty acid in the reaction mixture stabilizes the glycopyrronium fatty acid salt and reduces the formation of the impurity, Acid A. In some preferred embodiments, between 0.2 and 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture. In another embodiment, approximately 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture.

US Patent:

20150376665, Dec 31, 2015

Filed:

Jul 1, 2015

Appl. No.:

14/789840

Inventors:

- Lexington MA, US
Steven A. Weissman - Short Hills NJ, US
Emerich Eisenreich - Claremont CA, US
Xuejun Liu - Arcadia CA, US

International Classification:

C12P 17/18
C07D 473/10

Abstract:

The present invention provides a process for the preparation of enantiomerically enriched, deuterated secondary alcohols of Formula 1-A by employing ketoreductases or carbonyl reductases without reducing deuterium incorporation.