Yan Yi Feng

US Patent:

6890933, May 10, 2005

Filed:

Feb 23, 2001

Appl. No.:

09/791339

Inventors:

Yan Feng - Brookline MA, US
Tarun M. Kapoor - New York NY, US
Thomas Mayer - Brookline MA, US
Zoltan Maliga - East Brunswick NJ, US
Timothy J. Mitchison - Brookline MA, US
Justin Yarrow - Boston MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K031/437
C02D471/04

US Classification:

514292, 546 85, 546 86

Abstract:

The present invention provides for compounds, compositions, methods and systems for inhibiting cell growth. More specifically, the present invention provides for methods, compounds and compositions which are capable of inhibiting mitosis in metabolically active cells. Compounds, compositions and methods of the present invention inhibit the activity of a protein involved in the assembly and maintenance of the mitotic spindle. One class of proteins which acts on the mitotic spindle is the family of mitotic kinesins, a subset of the kinesin superfamily.

US Patent:

20050004156, Jan 6, 2005

Filed:

Jul 26, 2004

Appl. No.:

10/899495

Inventors:

Yan Feng - Brookline MA, US
Tarun Kapoor - New York NY, US
Thomas Mayer - Munchen, DE
Zoltan Maliga - East Brunswick NJ, US
Timothy Mitchison - Brooklin MA, US
Justin Yarrow - Boston MA, US

International Classification:

C07D471/14
A61K031/4745

US Classification:

514287000, 546064000

Abstract:

The present invention provides for compounds, compositions, methods and systems for inhibiting cell growth. More specifically, the present invention provides for methods, compounds and compositions which are capable of inhibiting mitosis in metabolically active cells. Compounds, compositions and methods of the present invention inhibit the activity of a protein involved in the assembly and maintenance of the mitotic spindle. One class of proteins which acts on the mitotic spindle is the family of mitotic kinesins, a subset of the kinesin superfamily.

US Patent:

20060050946, Mar 9, 2006

Filed:

May 12, 2003

Appl. No.:

10/435827

Inventors:

Timothy Mitchison - Brookline MA, US
Steven Altschuler - Cambridge MA, US
Yan Feng - Andover MA, US
Thomas Mayer - Munchen, DE
Zachary Perlman - Boston MA, US
Michael Slack - La Mesa CA, US
Lani Wu - Cambridge MA, US

International Classification:

G06K 9/00

US Classification:

382133000

Abstract:

The present invention provides methods and systems for automated morphological analysis of cells. The inventive methods are particularly useful in the rapid analysis of cells required in a biological screen. Agents which cause a particular phenotype in the cells can be identified using the inventive quantitative morphometric analysis of cells. The data gathered using the inventive method can also be quantified and analyzed later for various trends and classifications. Characteristics of cells which can be determined using this method include number of nuclei, size of cell, size of nuclei, number of the centrosomes, shape of cells, size of centrosomes, perimeter of nucleus, shape of nucleus, pattern of staining, and degree of staining.

US Patent:

20100063141, Mar 11, 2010

Filed:

Jul 15, 2009

Appl. No.:

12/503384

Inventors:

Brian Seed - Boston MA, US
Binhua LV - Shanghai, CN
Jacques Y. Roberge - Shanghai, CN
Yuanwei Chen - North Haven CT, US
Kun Peng - Shanghai, CN
Jiajia Dong - San Diego CA, US
Baihua Xu - Shanghai, CN
Jiyan Du - Shanghai, CN
Lili Zhang - Shanghai, CN
Xinxing Tang - Shanghai, CN
Ge Xu - Shanghai, CN
Yan Feng - Ridgefield NJ, US
Min Xu - Shanghai, CN

Assignee:

Theracos, Inc. - Sunnyvale CA

International Classification:

A61K 31/35
C07D 315/00
C07C 15/16

US Classification:

514460, 549417, 585400

Abstract:

Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by SGLT inhibition.