Yan Sheng Li

US Patent:

8304526, Nov 6, 2012

Filed:

Jul 2, 2010

Appl. No.:

12/829651

Inventors:

Mien-Chie Hung - Houston TX, US
Yan Li - Houston TX, US
Yong Wen - Burlingame CA, US

Assignee:

The Board of Regents of the University of Texas System - Austin TX

International Classification:

C07H 21/04

US Classification:

536 235

Abstract:

The present invention regards mutant forms of Bik that comprise anti-cell proliferation and/or pro-apoptotic activities. In particular embodiments, the Bik polypeptides comprise a substitution at Thr33 and Ser35 and, in some embodiments, phosphorylation at these sites is inhibited. In more particular embodiments, these forms are useful for cancer therapy, particularly when administered in combination with liposomes. In embodiments wherein a mutant Bik polynucleotide is administered for cancer therapy, the polynucleotide may be regulated in a tissue-specific manner.

US Patent:

8514820, Aug 20, 2013

Filed:

Feb 14, 2011

Appl. No.:

13/026820

Inventors:

Lujing Cai - Morganville NJ, US
Benoit Pelletier - Quebec, CA
Hong O. Zhang - Manalapan NJ, US
Fengjun Xi - Huntington Station NY, US
Yan Li - Coopersburg PA, US
Yingxue K. Li - Exton PA, US
Christopher R. Cave - Quebec, CA

Assignee:

InterDigital Patent Holdings, Inc. - Wilmington DE

International Classification:

H04J 3/00
H04W 4/00

US Classification:

370336, 370328

Abstract:

Feedback information for multiple serving cells are transmitted on high speed dedicated physical control channel (HS-DPCCH). A slot format for transmitting feedback information is determined based on the number of configured secondary serving cells and whether multiple input multiple-output (MIMO) is configured in the serving cells. Spreading factor is reduced to 128 when two secondary serving cells are configured and MIMO is configured in at least one of the two configured secondary serving cells, or when three secondary serving cells are configured. The serving cells are grouped into feedback groups, each feedback group having one or more serving cells. Channel coding may be applied to feedback information for the feedback groups. The resulting encoded feedback information for the feedback groups is concatenated to form composite feedback information.

US Patent:

20050118154, Jun 2, 2005

Filed:

Apr 2, 2004

Appl. No.:

10/816698

Inventors:

Mien-Chie Hung - Houston TX, US
Yan Li - Houston TX, US
Yong Wen - South San Francisco CA, US

International Classification:

A61K048/00
G01N033/53
G01N033/567
A61K038/53
C12N009/99

US Classification:

424094500, 435184000, 514044000

Abstract:

The present invention regards mutant forms of Bik that comprise anti-cell proliferation and/or pro-apoptotic activities. In particular embodiments, the Bik polypeptides comprise a substitution at Thr33 and Ser35 and, in some embodiments, phosphorylation at these sites is inhibited. In more particular embodiments, these forms are useful for cancer therapy, particularly when administered in combination with liposomes. In embodiments wherein a mutant Bik polynucleotide is administered for cancer therapy, the polynucleotide may be regulated in a tissue-specific manner.

US Patent:

20090075885, Mar 19, 2009

Filed:

Jul 28, 2008

Appl. No.:

12/180730

Inventors:

Mien-Chie Hung - Houston TX, US
Yan Li - Houston TX, US
Yong Wen - Burlingame CA, US

International Classification:

A61K 38/00
A61P 31/00

US Classification:

514 12

Abstract:

The present invention regards mutant forms of Bik that comprise anti-cell proliferation and/or pro-apoptotic activities. In particular embodiments, the Bik polypeptides comprise a substitution at Thr33 and Ser35 and, in some embodiments, phosphorylation at these sites is inhibited. In more particular embodiments, these forms are useful for cancer therapy, particularly when administered in combination with liposomes. In embodiments wherein a mutant Bik polynucleotide is administered for cancer therapy, the polynucleotide may be regulated in a tissue-specific manner.

US Patent:

20120275403, Nov 1, 2012

Filed:

Apr 28, 2012

Appl. No.:

13/459133

Inventors:

Hong O. Zhang - Manalapan NJ, US
Benoit Pelletier - Roxboro, CA
Yan Li - Morganville NJ, US
Joseph S. Levy - Merrick NY, US
Chao-Cheng Tu - Montreal, CA
Lujing Cai - Morganville NJ, US
Damian C. Hamme - Horsham PA, US

Assignee:

INTERDIGITAL PATENT HOLDINGS, INC. - Wilmington DE

International Classification:

H04W 52/52
H04W 72/02

US Classification:

370329

Abstract:

Systems, methods, and instrumentalities are disclosed herein to determine a gain factor. A user equipment (UE) may determine that an S-E-DPCCH and an E-DPCCH are to be transmitted on a primary stream. The UE may calculate an E-DPCCH gain factor using a gain factor calculation and apply the -DPCCH gain factor. The UE may calculate an E-DPCCH gain factor reduction. For example, the E-DPCCH gain factor reduction may compensate for changes from single stream transmission to multiple stream transmission. The UE may apply the E-DPCCH gain factor reduction to the E-DPCCH gain factor. The UE may apply the E-DPCCH gain factor reduction to an S-E-DPCCH gain factor.

US Patent:

20130003788, Jan 3, 2013

Filed:

Jan 6, 2012

Appl. No.:

13/345047

Inventors:

Paul Marinier - Brossard, CA
Afshin Haghighat - Ile-Bizard, CA
Guodong Zhang - Syosset NY, US
Diana Pani - Montreal, CA
J. Patrick Tooher - Montreal, CA
Marian Rudolf - Montreal, CA
Ghyslain Pelletier - Laval, CA
Christopher Cave - Dollard-des-Ormeaux, CA
Yan Li - Coopersburg PA, US
Allan Y. Tsai - Boonton NJ, US
Pascal M. Adjakple - Great Neck NY, US

Assignee:

INTERDIGITAL PATENT HOLDINGS, INC. - Wilmington DE

International Classification:

H04B 1/38

US Classification:

375219

Abstract:

Embodiments contemplate methods and systems for determining and communicating channel state information (CSI) for one or more transmission points (or CSI reference signal resources). Embodiments further contemplate determining transmission states may include applying at least one transmission state parameter to channel state information (CSI). Embodiments also contemplate reporting CSI based on the transmission state and/or at least one transmission state parameter applied thereto.

US Patent:

20220292338, Sep 15, 2022

Filed:

Mar 9, 2021

Appl. No.:

17/195755

Inventors:

- San Ramon CA, US
- Los Alamos NM, US
Yan Li - Houston TX, US
Margaretha Catharina Maria Rijken - Houston TX, US
Velimir Valentinov Vesselinov - Los Alamos NM, US

International Classification:

G06N 3/08
G06N 3/04

Abstract:

A computer implemented method for prediction of geomechanical performance including productivity index decline and completion integrity for a well or a hydrocarbon reservoir using a geomechanics informed machine intelligence (GIMI) algorithm. The method includes running a geomechanical reservoir simulator to generate training datasets for the hydrocarbon reservoir and incorporating physical models and identified variables into the GIMI algorithm. The method further includes training a neural network of the GIMI algorithm by using correlated training datasets that correlate to the physical models to produce a resulting prediction model and performing sensitivity analysis on the resulting prediction model. Additionally, the method includes identifying dominant variables for damage mechanisms through design of experiment statistics and performing history matching and blind test on the resulting prediction model. Lastly, the method includes updating the identified variables and models incorporated into the GIMI algorithm.

US Patent:

20210096277, Apr 1, 2021

Filed:

Sep 25, 2020

Appl. No.:

17/033155

Inventors:

- San Ramon CA, US
Yan LI - Bellaire TX, US
Yunhui TAN - Katy TX, US
Ruiting WU - Sugar Land TX, US
Margaretha Catharina Maria RIJKEN - Houston TX, US
Amr Said EL-FAYOUMI - Houston TX, US
Pietro VALSECCHI - Duesseldorf, DE

Assignee:

CHEVRON U.S.A.INC. - San Ramon CA

International Classification:

G01V 99/00
E21B 47/06
G06F 30/20

Abstract:

Embodiments of evaluating production performance for a wellbore while accounting for subterranean reservoir geomechanics and wellbore completion are provided. One embodiment includes generating the wellbore model; defining geomechanical properties for the subterranean reservoir in the near wellbore region and the far field region, and completion variables for the wellbore completion; and simulating fluid flow in the near wellbore region, the far field region, and the wellbore completion to evaluate production performance for the wellbore over a period of time. A permeability of the subterranean reservoir and a contact area between the wellbore and the subterranean reservoir are updated during simulation over the period of time. The permeability and the contact area are updated as a function of a change in pressure and the geomechanical properties for the subterranean reservoir in the near wellbore region and the far field region, the completion variables for the wellbore completion, or any combination thereof.