Yan Sheng Li

US Patent:

6956770, Oct 18, 2005

Filed:

Sep 17, 2003

Appl. No.:

10/667223

Inventors:

Shahzad Khalid - West Los Angeles CA, US
Yan Li - Milpitas CA, US
Mehrdad Mofidi - Fremont CA, US

Assignee:

SanDisk Corporation - Sunnyvale CA

International Classification:

G11C016/04

US Classification:

36518512, 36518517, 36518522

Abstract:

When programming a contiguous page of memory storage units, every time a memory storage unit has reached its targeted state and is program-inhibited or locked out from further programming, it creates a perturbation on an adjacent memory storage unit still under programming. The present invention provides as part of a programming circuit and method in which an offset to the perturbation is added to the adjacent memory storage unit still under programming. The offset is added as voltage offset to a bit line of a storage unit under programming. The voltage offset is a predetermined function of whether none or one or both of its neighbors are in a mode that creates perturbation, such as in a program inhibit mode. In this way, an error inherent in programming in parallel high-density memory storage units is eliminated or minimized.

US Patent:

7215574, May 8, 2007

Filed:

Oct 13, 2005

Appl. No.:

11/250357

Inventors:

Shahzad Khalid - West Los Angeles CA, US
Yan Li - Milpitas CA, US
Mehrdad Mofidi - Fremont CA, US

Assignee:

Sandisk Corporation - Milpitas CA

International Classification:

G11C 11/34
G11C 16/04

US Classification:

36518512, 36518517

Abstract:

When programming a contiguous page of memory storage units, every time a memory storage unit has reached its targeted state and is program-inhibited or locked out from further programming, it creates a perturbation on an adjacent memory storage unit still under programming. The present invention provides as part of a programming circuit and method in which an offset to the perturbation is added to the adjacent memory storage unit still under programming. The offset is added as voltage offset to a bit line of a storage unit under programming. The voltage offset is a predetermined function of whether none or one or both of its neighbors are in a mode that creates perturbation, such as in a program inhibit mode. In this way, an error inherent in programming in parallel high-density memory storage units is eliminated or minimized.

US Patent:

8304526, Nov 6, 2012

Filed:

Jul 2, 2010

Appl. No.:

12/829651

Inventors:

Mien-Chie Hung - Houston TX, US
Yan Li - Houston TX, US
Yong Wen - Burlingame CA, US

Assignee:

The Board of Regents of the University of Texas System - Austin TX

International Classification:

C07H 21/04

US Classification:

536 235

Abstract:

The present invention regards mutant forms of Bik that comprise anti-cell proliferation and/or pro-apoptotic activities. In particular embodiments, the Bik polypeptides comprise a substitution at Thr33 and Ser35 and, in some embodiments, phosphorylation at these sites is inhibited. In more particular embodiments, these forms are useful for cancer therapy, particularly when administered in combination with liposomes. In embodiments wherein a mutant Bik polynucleotide is administered for cancer therapy, the polynucleotide may be regulated in a tissue-specific manner.

US Patent:

20050118154, Jun 2, 2005

Filed:

Apr 2, 2004

Appl. No.:

10/816698

Inventors:

Mien-Chie Hung - Houston TX, US
Yan Li - Houston TX, US
Yong Wen - South San Francisco CA, US

International Classification:

A61K048/00
G01N033/53
G01N033/567
A61K038/53
C12N009/99

US Classification:

424094500, 435184000, 514044000

Abstract:

The present invention regards mutant forms of Bik that comprise anti-cell proliferation and/or pro-apoptotic activities. In particular embodiments, the Bik polypeptides comprise a substitution at Thr33 and Ser35 and, in some embodiments, phosphorylation at these sites is inhibited. In more particular embodiments, these forms are useful for cancer therapy, particularly when administered in combination with liposomes. In embodiments wherein a mutant Bik polynucleotide is administered for cancer therapy, the polynucleotide may be regulated in a tissue-specific manner.

US Patent:

20070282313, Dec 6, 2007

Filed:

Jun 1, 2007

Appl. No.:

11/757195

Inventors:

David Huang - South Pasadena CA, US
Jonathan Song - South Pasadena CA, US
Yan Li - Pasadena CA, US
Maolong Tang - San Gabriel CA, US

Assignee:

University of Southern California - Los Angeles CA

International Classification:

A61B 18/18

US Classification:

606005000

Abstract:

Optical coherence tomography (OCT) is used to map the surface elevation and thickness of the cornea. The OCT maps are used to plan laser procedures for the treatment of an irregular, opacified or weakened cornea, and in the treatment of refractive errors. In the excimer laser phototherapeutic keratectomy (PTK) procedure, the OCT data is used to plan a map of ablation depth needed to restore a smooth optical surface. In the excimer laser photorefractive keratectomy procedure, OCT mapping of epithelial thickness is used to achieve clean laser epithelial removal. In femtosecond laser anterior keratoplasty procedure, OCT data is used to plan the depth of femtosecond laser dissection to remove an anterior layer of the cornea, leaving a smooth recipient bed of uniform thickness to receive a disk of donated corneal tissue. The linkage of an OCT system to a precise laser surgical system enables the performance of new procedures that are safer, less invasive and produce faster visual recovery than conventional surgical procedures.

US Patent:

20090075885, Mar 19, 2009

Filed:

Jul 28, 2008

Appl. No.:

12/180730

Inventors:

Mien-Chie Hung - Houston TX, US
Yan Li - Houston TX, US
Yong Wen - Burlingame CA, US

International Classification:

A61K 38/00
A61P 31/00

US Classification:

514 12

Abstract:

The present invention regards mutant forms of Bik that comprise anti-cell proliferation and/or pro-apoptotic activities. In particular embodiments, the Bik polypeptides comprise a substitution at Thr33 and Ser35 and, in some embodiments, phosphorylation at these sites is inhibited. In more particular embodiments, these forms are useful for cancer therapy, particularly when administered in combination with liposomes. In embodiments wherein a mutant Bik polynucleotide is administered for cancer therapy, the polynucleotide may be regulated in a tissue-specific manner.

US Patent:

20220292338, Sep 15, 2022

Filed:

Mar 9, 2021

Appl. No.:

17/195755

Inventors:

- San Ramon CA, US
- Los Alamos NM, US
Yan Li - Houston TX, US
Margaretha Catharina Maria Rijken - Houston TX, US
Velimir Valentinov Vesselinov - Los Alamos NM, US

International Classification:

G06N 3/08
G06N 3/04

Abstract:

A computer implemented method for prediction of geomechanical performance including productivity index decline and completion integrity for a well or a hydrocarbon reservoir using a geomechanics informed machine intelligence (GIMI) algorithm. The method includes running a geomechanical reservoir simulator to generate training datasets for the hydrocarbon reservoir and incorporating physical models and identified variables into the GIMI algorithm. The method further includes training a neural network of the GIMI algorithm by using correlated training datasets that correlate to the physical models to produce a resulting prediction model and performing sensitivity analysis on the resulting prediction model. Additionally, the method includes identifying dominant variables for damage mechanisms through design of experiment statistics and performing history matching and blind test on the resulting prediction model. Lastly, the method includes updating the identified variables and models incorporated into the GIMI algorithm.

US Patent:

20230125467, Apr 27, 2023

Filed:

Nov 18, 2022

Appl. No.:

18/056966

Inventors:

- Oakland CA, US
Yusi Miao - Irvine CA, US
Yan Li - Irvine CA, US
Bruce J. Tromberg - Irvine CA, US
Yona Tadir - Irvine CA, US

International Classification:

A61B 5/00
A61B 5/145
A61B 1/303
A61B 8/00
A61B 8/08
G06T 7/149
G06T 7/162
G06T 7/136

Abstract:

The present invention features a method for automated image-based prediction of physiologic and pathologic conditions of a vaginal wall of a patient using optical coherence tomography. In some embodiments, the method may comprise capturing, by a functional optical coherence tomography imaging probe, one or more images of the vaginal wall. The method may further comprise constructing a computing device a visualization of the vaginal wall, discretizing the visualization of the vaginal wall in to a discrete model, measuring a plurality of objective attributes from the discrete model, generating, based on the plurality of objective attributes, a Vaginal Health Index (VHI), generating an associated risk value based on the VHI and a plurality of patient attributes, reconstructing the visualization of the vaginal wall based on the associated risk value, and mapping the associated risk value to the visualization of the vaginal wall such that one or more at-risk areas are highlighted.