Yan R Qiu

US Patent:

20110224139, Sep 15, 2011

Filed:

Feb 17, 2011

Appl. No.:

13/029891

Inventors:

Vincent Frans Maria Segers - Bornem, BE
Anthony Sandrasagra - Arlington MA, US
Yan Qiu - Jamaica Plain MA, US

Assignee:

Provasculon, Inc. - Cambridge MA

International Classification:

A61K 38/18
C07K 7/08
C07K 7/06
C07K 14/475
C07H 21/04
A61P 17/02
A61P 9/10

US Classification:

514 94, 530324, 530325, 530326, 530327, 530328, 530350, 536 235, 514 76

Abstract:

The present invention features mutant stromal cell derived factor-1 (SDF-1) peptides that have been mutated to make them resistant to digestion by, for example, the proteases dipeptidyl peptidase IV (DPPIV), matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), leukocyte elastase, cathepsin G, carboxypeptidase M, and carboxypeptidase N, but which retain chemoattractant activity.

US Patent:

58010130, Sep 1, 1998

Filed:

May 26, 1995

Appl. No.:

8/451715

Inventors:

Jianshi Tao - Needham MA
Yan Qiu - Brookline MA
Fariba Houman - Belmont MA
Xiaoyu Shen - S. Boston MA
Paul R. Schimmel - Cambridge MA

Assignee:

Cubist Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C12N 1500
C12N 1563
C07K 14195
C07H 2104

US Classification:

435 691

Abstract:

Recombinant nucleic acids which encode aminoacyl-tRNA sythetases of helicobacter origin have been isolated. These nucleic acids can be used to make expression constructs and transformed host cells for the production of helicobacter aminoacyl-tRNA synthetases. They can also be used in the further isolation of nucleic acids related by DNA sequence similarities, which also encode helicobacter aminoacyl-tRNA synthetases, or portions thereof. A further embodiment of the invention is antisense nucleic acid which can hybridize to the nucleic acid which encodes the aminoacyl-tRNA synthetase of helicobacter. The invention also relates to isolated and/or recombinant helicobacter aminoacyl-tRNA synthetases. Antibodies which bind to these enzymes can be made and can be used in the purification and study of the enzymes. Also described are tester strains, which are cells engineered to rely on the function of the tRNA synthetase encoded by an introduced cloned gene, and which can be used to test the effectiveness of drug candidates in the inhibition of an essential aminoacyl-tRNA synthetase encoded by an introduced cloned helicobacter gene.

US Patent:

20160375100, Dec 29, 2016

Filed:

Feb 26, 2016

Appl. No.:

15/054456

Inventors:

- Meyrin, CH
Anthony SANDRASAGRA - Arlington MA, US
Yan QIU - Jamaica Plain MA, US

International Classification:

A61K 38/19

Abstract:

The present invention features mutant stromal cell derived factor-1 (SDF-1) peptides that have been mutated to make them resistant to digestion by, for example, the proteases dipeptidyl peptidase IV (DPPIV), matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), leukocyte elastase, cathepsin G, carboxypeptidase M, and carboxypeptidase N, but which retain chemoattractant activity.