Yanan N Feng

US Patent:

20080176962, Jul 24, 2008

Filed:

Aug 2, 2007

Appl. No.:

11/890314

Inventors:

Stanley N. Cohen - Stanford CA, US
Daniel Rock - Stanford CA, US
Annie Chang - Stanford CA, US
Yanan Feng - Stanford CA, US
Laszlo Zsak - Stanford CA, US
Maria Elisa Piccone - Old Say Brook CT, US

International Classification:

A61K 47/00
C40B 30/06
C40B 40/02
A01K 67/027
A61P 43/00

US Classification:

514789, 506 10, 506 14, 800 13

Abstract:

Methods and compositions for rapidly identifying CGEPs required for viral infection of mammalian cells are provided. Also provided are methods of inhibiting viral infection of mammalian cells by inhibiting the activity of one or more CGEPs (e.g., as identified in accordance with methods of the invention) in the cells. Aspects of the invention further include specifically identified CGEPs implicated in mammalian cell infection of specific viruses, e.g., African Swine Fever Virus and Foot and Mouth Virus, and methods of modulating their activity to achieve viral resistance.

US Patent:

20180064744, Mar 8, 2018

Filed:

May 18, 2016

Appl. No.:

15/554679

Inventors:

- Stanford CA, US
- Taipei, TW
Yanan Feng - San Jose CA, US
Tzu-Hao Cheng - Taipei, TW
Yun-Yun Wu - Taipei, TW
Wen-Chieh Hsieh - Taipei, TW

International Classification:

A61K 31/7076
C12N 15/113
G01N 33/50

Abstract:

Aspects of the invention include methods of reducing the deleterious activity of a mutant extended nucleotide repeat (NR) containing target gene in a cell by contacting the cell with an effective amount of a nucleoside agent, as well as compositions used in such methods. The deleterious activity (e.g., toxicity and/or dis-functionality of products encoded thereby) of a mutant extended NR containing target gene may be reduced in a variety of different ways, e.g., by reducing (and in some instances differentially, including selectively, reducing) the production or activity of toxic expression products (e.g., RNA or protein) encoded by the target gene. Kits and compositions for practicing the subject methods are also provided.