Yanni Zhang from Irvine, CA

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Location:

United States

Thyroglobulin Quantitation By Mass Spectrometry
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US Patent:

8455259, Jun 4, 2013
Filed:

Aug 4, 2011
Appl. No.:

13/198620
Inventors:

Yanni Zhang - Aliso Viejo CA, US
Nigel J. Clarke - Oceanside CA, US
Richard E. Reitz - San Clemente CA, US
Assignee:

Quest Diagnostics Investments Incorporated - Wilmington DE
International Classification:

C12Q 1/37
C12Q 1/00
US Classification:

436 86, 436171, 436173, 435 619, 435 71, 435 23
Abstract:

Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.

Glucagon Detection And Quantitation By Mass Spectrometry
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US Patent:

8497079, Jul 30, 2013
Filed:

Dec 20, 2010
Appl. No.:

13/517483
Inventors:

Yanni Zhang - Mission Viejo CA, US
Nigel J. Clarke - Oceanside CA, US
Assignee:

Quest Diagnostics Investments Incorporated - Wilmington DE
International Classification:

G01N 33/53
G01N 31/00
US Classification:

435 721, 435 71, 436501, 436518, 424 91, 424520, 530300, 530350
Abstract:

Methods are described for measuring the amount of glucagon in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying glucagon in a sample.

Thyroglobulin Quantitation By Mass Spectrometry
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US Patent:

20090148951, Jun 11, 2009
Filed:

Dec 6, 2007
Appl. No.:

12/001076
Inventors:

Yanni Zhang - Mission Viejo CA, US
Nigel J. Clarke - Oceanside CA, US
Richard E. Reitz - San Clemente CA, US
International Classification:

G01N 33/00
C12Q 1/00
US Classification:

436 86, 435 4
Abstract:

Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.