Yanxia Li

US Patent:

8263079, Sep 11, 2012

Filed:

Mar 28, 2011

Appl. No.:

13/073004

Inventors:

Jacqueline Francoise Doody - Ozone Park NY, US
Yanxia Li - Floral Park NY, US

Assignee:

ImClone, LLC - Indianapolis IN

International Classification:

A61K 39/395
C12P 21/08

US Classification:

4241431, 4241421

Abstract:

The invention provides a human antibody that binds human CSF-1R with high affinity. Antibodies of the present invention have significant advantages over the antibodies known in the art by being multifunctional: inhibiting signaling of CSF-1R, internalizing and inducing CSF-1R degradation and stimulating ADCC in cell including tumors, macrophages and monocytes. They are also shown to be effective in treating leukemia, breast, endometrial and prostate cancer alone or in combination with docetaxel, paclitaxel, Herceptin or doxorubicin.

US Patent:

20040222744, Nov 11, 2004

Filed:

Nov 19, 2003

Appl. No.:

10/718258

Inventors:

Robert Tornoe - Sunol CA, US
Yanxia Li - Pleasanton CA, US
Paul Krzeminski - San Mateo CA, US
Edmund Davies - Orinda CA, US
Leroy Higgins - Newark CA, US
Gordon Lavering - Belmont CA, US

Assignee:

Communications & Power Industries, Inc.,

International Classification:

H01J025/34

US Classification:

315/003500

Abstract:

An electrode structure for a vacuum tube is formed by having a ceramic insulating body act as the tube wall. Electrode areas are formed on the inside of the tube by coating the inside of the tube wall with a conductor. These electrode areas are then coupled, as necessary, to external electronic circuits. The coupling may be performed by through-wall connections, metallized abutting connections and other conventional means. The ceramic insulating body may be generally cylindrical in shape and may be formed of a material such as aluminum nitride, beryllium oxide, aluminum oxide and the like.

US Patent:

20060091831, May 4, 2006

Filed:

Nov 4, 2004

Appl. No.:

10/982192

Inventors:

Heinz Bohlen - Kehl, DE
Yanxia Li - Pleasanton CA, US
Paul Krzeminski - San Mateo CA, US
Edmund Davies - Orinda CA, US
Robert Tornoe - Sunol CA, US

International Classification:

H05H 13/00

US Classification:

315502000

Abstract:

An inductive output tube (IOT) operates in a frequency range above 1000 MHz. An output window may be provided to separate a vacuum portion of the IOT from an atmospheric pressure portion of the IOT, the output window being surrounded by a cooling air manifold, the manifold including an air input port and a plurality of apertures permitting cooling air to move from the port, through the manifold and into the atmospheric pressure portion of the IOT. The output cavity may include a liquid coolant input port; a lower circular coolant channel coupled to receive liquid coolant from the liquid coolant input port; a vertical coolant channel coupled to receive liquid coolant from the lower circular coolant channel; an upper circular coolant channel coupled to receive liquid coolant from the vertical coolant channel; and a liquid coolant exhaust port coupled to receive liquid coolant from the upper circular coolant channel.

US Patent:

20070080762, Apr 12, 2007

Filed:

Dec 4, 2006

Appl. No.:

11/633850

Inventors:

Heinz Bohlen - Kehl, DE
Yanxia Li - Pleasanton CA, US
Paul Krzeminski - San Mateo CA, US
Edmund Davies - Orinda CA, US
Robert Tornoe - Sunol CA, US

Assignee:

Communications & Power Industries, Inc. - Palo Alto CA

International Classification:

H01P 7/06

US Classification:

333227000

Abstract:

An inductive output tube (IOT) operates in a frequency range above 1000 MHz. An output window may be provided to separate a vacuum portion of the IOT from an atmospheric pressure portion of the IOT, the output window being surrounded by a cooling air manifold, the manifold including an air input port and a plurality of apertures permitting cooling air to move from the port, through the manifold and into the atmospheric pressure portion of the IOT. The output cavity may include a liquid coolant input port; a lower circular coolant channel coupled to receive liquid coolant from the liquid coolant input port; a vertical coolant channel coupled to receive liquid coolant from the lower circular coolant channel; an upper circular coolant channel coupled to receive liquid coolant from the vertical coolant channel; and a liquid coolant exhaust port coupled to receive liquid coolant from the upper circular coolant channel.