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Yasuo Irie

age ~75

from Salem, NH

Also known as:
  • Yasuo Iriye
Phone and address:
11 Chestnut Dr, Salem, NH 03079

Yasuo Irie Phones & Addresses

  • 11 Chestnut Dr, Salem, NH 03079
  • 21 Rocky Rd, Reading, MA 01867
  • 14 Lafayette Pl, Woburn, MA 01801 • (781)9388251
  • 14957 Dufief Ct, Gaithersburg, MD 20878 • (301)4244170
  • North Potomac, MD

Us Patents

  • Composition For Determining Pyrimidine Metabolizing Activity

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  • US Patent:
    6797256, Sep 28, 2004
  • Filed:
    Aug 14, 2001
  • Appl. No.:
    09/928434
  • Inventors:
    Makoto Inada - Tokushima-ken, JP
    Nobuhiro Ikei - Tokushima, JP
    Hideji Nonomura - Tokushima-ken, JP
    Yasuo Irie - Woburn MA
  • Assignee:
    Otsuka Pharmaceutical Co. Ltd. - Tokyo-To
  • International Classification:
    A61K 5100
  • US Classification:
    424 91, 424 92, 424 93, 424 181, 436173
  • Abstract:
    The present invention provide a method for assessing the sensitivity to a pyrimidine drug such as 5-FU which is degraded in the pyrimidine metabolic pathway, specifically in vivo pyrimidine metabolizing activity, of an individual subject; and a preparation useful for the assessment. The present invention can be carried out by: administering a preparation comprising as an active ingredient a pyrimidine compound or its metabolite which acts as a substrate for a pyrimidine metabolizing enzyme, in which compound or metabolite at least one of C, O and N is labeled with an isotope; and assessing in vivo pyrimidine metabolizing activity based on the amount of excreted metabolite.
  • Reagent And Method For Measuring Lung Function

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  • US Patent:
    6890305, May 10, 2005
  • Filed:
    Feb 26, 2003
  • Appl. No.:
    10/372982
  • Inventors:
    Yasuo Irie - Reading MA, US
    Anil S. Modak - Methuen MA, US
  • Assignee:
    Cambridge Isotope Laboratories - Andover MA
  • International Classification:
    A61B005/00
  • US Classification:
    600532, 73 233, 422 84
  • Abstract:
    The present invention relates to an assay for evaluating alveolar exchange of oxygen. A C-labeled substrate, such as C-sodium bicarbonate is administered to a subject by oral or iv intake, and exhaled COis measured. The COin expired breath can be collected at various time points following administration of the substrate and measured in Δ per mil with a mass analyzer or photometer, such as an IR spectrometer. This process can be used as a diagnostic test for the indication of, treatment and/or evaluation of the severity of respiratory tract diseases or infections.
  • Preparation For Determining Pyrimidine Metabolic Capacity

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  • US Patent:
    7488466, Feb 10, 2009
  • Filed:
    Aug 1, 2002
  • Appl. No.:
    10/208851
  • Inventors:
    Makoto Inada - Tokushima-ken, JP
    Nobuhiro Ikei - Tokushima, JP
    Hideji Nonomura - Tokushima-ken, JP
    Yasuo Irie - Woburn MA, US
  • Assignee:
    Otsuka Pharmaceutical Co., Ltd. - Tokyo-to
  • International Classification:
    A61K 51/00
    A61M 36/14
  • US Classification:
    424 181, 424 111, 424 165, 424 173, 424 92
  • Abstract:
    The present invention provide a method for measuring and assessing the capacity in an individual subject to metabolize a variety of fluorouracil drugs, such as 5-fluorouracil, which are degraded in the pyrimidine metabolic pathway, and a preparation useful for the measurement and assessment. The present invention can be carried out by: administering a preparation for determining pyrimidine metabolic capacity comprising as an active ingredient a pyrimidine compound or pyrimidine metabolic compound that acts as a substrate for a pyrimidine metabolizing enzyme, in which at least one of the carbon, oxygen, and nitrogen atoms is labeled with an isotope; and assessing in vivo pyrimidine metabolic capacity based on the behavior of an excreted metabolite.
  • Composition For Determining Pyrimidine Metabolizing Activity

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  • US Patent:
    20040234452, Nov 25, 2004
  • Filed:
    May 24, 2004
  • Appl. No.:
    10/851198
  • Inventors:
    Makoto Inada - Tokushima-ken, JP
    Nobuhiro Ikei - Tokushima-shi, JP
    Hideji Nonomura - Tokushima-ken, JP
    Yasuo Irie - Woburn MA, US
  • Assignee:
    Otsuka Pharmaceutical Co., Ltd.
  • International Classification:
    A61K049/00
  • US Classification:
    424/009200
  • Abstract:
    The present invention provide a method for assessing the sensitivity to a pyrimidine drug such as 5-FU which is degraded in the pyrimidine metabolic pathway, specifically in vivo pyrimidine metabolizing activity, of an individual subject; and a preparation useful for the assessment. The present invention can be carried out by: administering a preparation comprising as an active ingredient a pyrimidine compound or its metabolite which acts as a substrate for a pyrimidine metabolizing enzyme, in which compound or metabolite at least one of C, O and N is labeled with an isotope; and assessing in vivo pyrimidine metabolizing activity based on the amount of excreted metabolite.
  • Method For Monitoring Patient Or Subject Compliance With Medical Prescriptions, And Formulation For Use In The Method

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  • US Patent:
    20060188444, Aug 24, 2006
  • Filed:
    Feb 23, 2005
  • Appl. No.:
    11/062554
  • Inventors:
    Yasuo Irie - Woburn MA, US
    Anil Modak - Methuen MA, US
    Tadashi Mukai - Naruto-shi, JP
  • International Classification:
    A61K 49/00
  • US Classification:
    424009100
  • Abstract:
    The present invention provides a highly accurate method for monitoring patient or subject compliance with a medication prescription by collecting a sample of the exhaled air. The method of the present invention is easy and little burdens the patient or subject. The method comprises the steps of: (i) prescribing a patient or subject ingestion of at least one biologically active agent and at least one carbon isotope-labeled lipid, (ii) obtaining a sample of the patient's or subject's exhaled air, (iii) measuring the ratio of the carbon isotope-labeled COrelative to COin the sample; and (iv) confirming the ingestion of the prescribed biologically active agent based on the ratio of the carbon isotope-labeled COrelative to CO.
  • Method And Composition To Evaluate Cytochrome P450 2D6 Isoenzyme Activity Using A Breath Test

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  • US Patent:
    20070026480, Feb 1, 2007
  • Filed:
    Apr 14, 2006
  • Appl. No.:
    11/404965
  • Inventors:
    Anil Modak - Methuen MA, US
    Yasuo Irie - Reading MA, US
    Yasuhisa Kurogi - North Andover MA, US
  • International Classification:
    C12Q 1/26
  • US Classification:
    435025000
  • Abstract:
    The present invention relates, generally to a method of determining and assessing cytochrome P450 2D6 isoenzyme (CYP2D6)-related metabolic capacity in an individual mammalian subject via a breath assay, by determining the relative amount of COexhaled by a the subject upon intravenous or oral administration of a C-labeled CYP2D6 substrate compound. The present invention is useful as an in vivo phenotype assay for evaluating CYP2D6-related activity using the metabolite COin expired breath and to determine the optimal dosage and timing of administration of CYP2D6 substrate compound.
Name / Title
Company / Classification
Phones & Addresses
Yasuo Irie
Director
GALENEA CORP
Industrial Building Construction · Research & Development in Biotechnology
50C Audubon Rd, Wakefield, MA 01880
300 Technology Sq, Cambridge, MA 02139
50 Audubon Rd, Wakefield, MA 01880
(617)3741010

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Lived:
Salem NH
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