John Howard Hutchinson - San Diego CA, US Brian Andrew Stearns - Encinitas CA, US Jill Melissa Scott - San Diego CA, US Yen Pham Truong - San Diego CA, US Jeffrey Roger Roppe - Temecula CA, US Nicholas Simon Stock - San Diego CA, US Jeannie M. Arruda - San Diego CA, US Thomas Jon Seiders - San Diego CA, US Bowei Wang - Westfield NJ, US Deborah Volkots - San Diego CA, US
Assignee:
Panmira Pharmaceuticals, LLC - San Diego CA
International Classification:
A61K 31/4418 A61K 31/195 C07D 213/64 C07C 229/00
US Classification:
514351, 514563, 514564, 546300, 562442, 562439
Abstract:
Described herein are compounds that are antagonists of PGDreceptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGDreceptors. Also described herein are methods of using such antagonists of PGDreceptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD-dependent or PGD-mediated conditions or diseases.
Compounds As Lysophosphatidic Acid Receptor Antagonists
Thomas Jon Seiders - San Diego CA, US Lucy Zhao - San Diego CA, US Jeannie M. Arruda - San Diego CA, US Brian Andrew Stearns - Encinitas CA, US Yen Pham Truong - San Diego CA, US Jill Melissa Scott - San Diego CA, US John Howard Hutchinson - San Diego CA, US Nicholas Simon Stock - San Diego CA, US Deborah Volkots - San Diego CA, US
Assignee:
Amira Pharmaceuticals, Inc. - Princeton NJ
International Classification:
A61K 31/42 C07D 261/14 C07D 261/08
US Classification:
514380, 514378, 548245, 548247
Abstract:
Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
Cyclic Diaryl Ether Compounds As Antagonists Of Prostaglandin Dreceptors
John Howard Hutchinson - San Diego CA, US Thomas Jonathan Seiders - San Diego CA, US Brian Andrew Stearns - Encinitas CA, US Bowei Wang - Westfield NJ, US Yen Pham Truong - San Diego CA, US Jeannie M. Arruda - San Diego CA, US
Assignee:
Panmira Pharmaceuticals, LLC - San Diego CA
International Classification:
A61K 31/195 A61K 31/4418 C07D 213/64 C07D 229/00
US Classification:
514351, 514563, 514564, 546300, 562439, 562442
Abstract:
Described herein are compounds that are antagonists of PGDreceptors. Also described are pharmaceutical compositions and medicaments that include the antagonists of PGDreceptors described herein, as well as methods of using such antagonists of PGDreceptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD-dependent or PGD-mediated conditions or diseases.
N,N-Disubstituted Aminoalkylbiphenyl Antagonists Of Prostaglandin D2 Receptors
John Howard Hutchinson - San Diego CA, US Brian Andrew Stearns - Encinitas CA, US Jill Melissa Scott - San Diego CA, US Yen Pham Truong - San Diego CA, US Jeffrey Roger Roppe - Temecula CA, US Nicholas Simon Stock - San Diego CA, US Jeannie M. Arruda - San Diego CA, US Thomas Jon Seiders - San Diego CA, US Bowei Wang - Westfield NJ, US Deborah Volkots - La Jolla CA, US
Assignee:
Panmira Pharmaceuticals, LLC - San Diego CA
International Classification:
A61K 31/4418 A61K 31/195
US Classification:
514351, 514563, 514564
Abstract:
Described herein are compounds that are antagonists of PGDreceptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGDreceptors. Also described herein are methods of using such antagonists of PGDreceptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD-dependent or PGD-mediated conditions or diseases.
Aminoalkylphenyl Antagonists Of Prostaglandin D2 Receptors
John Howard Hutchinson - San Diego CA, US Brian Andrew Stearns - Encinitas CA, US Yen Pham Truong - San Diego CA, US Thomas Jon Seiders - San Diego CA, US
Assignee:
Panmira Pharmaceuticals, LLC - San Diego CA
International Classification:
A01N 43/40 C07D 213/62 C07D 229/00
US Classification:
514351, 546300, 562442
Abstract:
Described herein are compounds that are antagonists of PGDreceptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGDreceptors. Also described herein are methods of using such antagonists of PGDreceptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD-dependent or PGD-mediated conditions or diseases.
Cycloalkane[B]Indole Antagonists Of Prostaglandin Dreceptors
John Howard Hutchinson - San Diego CA, US Brian Andrew Stearns - Encinitas CA, US Yen Pham Truong - San Diego CA, US
Assignee:
Panmira Pharmaceuticals, LLC - San Diego CA
International Classification:
C07D 209/94 A61K 31/40
US Classification:
548449, 514411
Abstract:
Described herein are compounds that are antagonists of PGDreceptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGDreceptors. Also described herein are methods of using such antagonists of PGDreceptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD-dependent or PGD-mediated conditions or diseases.
John Howard Hutchinson - La Jolla CA, US Thomas Jonathan Seiders - San Diego CA, US Brian Andrew Stearns - San Diego CA, US Bowei Wang - San Diego CA, US Jill Melissa Scott - San Diego CA, US Yen Pham Truong - San Diego CA, US
Assignee:
AMIRA PHARMACEUTICALS, INC. - San Diego CA
International Classification:
A61K 31/498 A61K 31/4745 C07D 487/04 C07D 471/04
US Classification:
514250, 514292, 546 82, 544346
Abstract:
Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of 5-lipoxygenase (5-LO). Also described herein are methods of using such 5-LO inhibitors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions, diseases, or disorders.
5-Lipoxygenase-Activating Protein (Flap) Inhibitors
John Hutchinson - La Jolla CA, US Petpiboon Prasit - Rancho Santa Fe CA, US Mark Moran - Orinda CA, US Jillian Evans - Carlsbad CA, US Brian Stearns - San Diego CA, US Jeffrey Roppe - Temecula CA, US Bowei Wang - San Diego CA, US Yen Truong - San Diego CA, US Yiwei Li - San Diego CA, US Jasmine Zunic - San Diego CA, US Jeannie Arruda - San Diego CA, US Nicholas Stock - San Diego CA, US Mustapha Haddach - San Diego CA, US Thomas Seiders - San Diego CA, US Jill Scott - San Diego CA, US
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.
Jasmin Wilsion, Sarah Shenton, De Walker, Amanda Fuchs, Kaste Greczynski, Eli Mclendon, Kenyahta Johnson, Ben Tom, Ner Siu, Andre Patterson, Jean Polo, Riqui Gonzalez