Yi Mia Zheng

US Patent:

20220331371, Oct 20, 2022

Filed:

Sep 8, 2020

Appl. No.:

17/640585

Inventors:

- Ann Arbor MI, US
Yi Zheng - Ann Arbor MI, US

International Classification:

A61K 35/545
A61K 35/50
C12N 5/0735
C12N 5/074

Abstract:

The present disclosure provides compositions and methods employing stem cell-derived embryo-like structures. In some embodiments, methods of generating embryo-like tissues from stem cells and the resulting tissues are provided. In some embodiments, uses of such tissues for research, compound screening and analysis, and therapeutics are provided. Accordingly, in some embodiments, provided herein is a method for preparing embryo-like tissue, comprising: a) introducing stem cells into a microfluidic device comprising a culture channel and a plurality of fluidic channels, wherein the stem cells are introduced to the culture channel of the microfluidic device; b) contacting the stem cells with basal medium via the plurality of fluidic channels for at least 18 hours (e.g., 36 hours) to generate the embryo-like tissue.

US Patent:

20190321415, Oct 24, 2019

Filed:

Dec 8, 2017

Appl. No.:

16/467154

Inventors:

- Ann Arbor MI, US
Deborah Gumucio - Ann Arbor MI, US
Yue Shao - Ann Arbor MI, US
Kenichiro Taniguchi - Ann Arbor MI, US
Yi Zheng - Ann Arbor MI, US
Sajedeh Nasr Esfahani - Ann Arbor MI, US

International Classification:

A61K 35/545
C12N 5/073
A61K 31/74
A61K 35/50
C12N 5/00
G01N 33/50

Abstract:

The present disclosure provides compositions and methods employing stem cell-derived amnion tissue. In some embodiments, compositions (e.g., scaffolds and devices) and methods of generating amnion-like tissues from hPSCs are provided. In some embodiments, uses of such cells for research, compound screening and analysis, and therapeutics are provided.