Yi Zhu

US Patent:

20230002488, Jan 5, 2023

Filed:

Nov 5, 2020

Appl. No.:

17/773240

Inventors:

- Redmond WA, US
- Chengdu, Sichuan, CN
Tsung-I Tsai - Redmond WA, US
Blair Renshaw - Renton WA, US
Andrew Waight - Kenmore WA, US
Nga Sze Amanda Mak - Mukilteo WA, US
Yi ZHU - Redmond WA, US

International Classification:

C07K 16/28
A61P 35/00
C07K 16/32
A61K 47/68

Abstract:

The application provides a multi-specific antibody-like protein having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first binding domain (D1) at the N-terminal, a second binding domain (D2) comprising a light chain moiety, a Fc region, a third binding domain (D3), and a fourth binding domain (D4) at the C-terminal, wherein the light chain moiety comprises a fifth binding domain (D5) covalently attached to the C-terminal, a sixth binding domain (D6) covalently attached to the N-terminal, or both, and wherein the D1, D2, D3, D4, D5 and D6 each has a binding specificity against a tumor antigen, an immune signaling antigen, or a combination thereof.