Yin Chien Chiu

US Patent:

20200284791, Sep 10, 2020

Filed:

Jan 23, 2020

Appl. No.:

16/751114

Inventors:

- Oakland CA, US
Yin To Chiu - Irvine CA, US
Benjamin Ming Wu - San Marino CA, US
Garrett L. Mosley - Newport Beach CA, US

International Classification:

G01N 33/558
G01N 33/543

Abstract:

Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum. In addition, these devices and methods may be used to detect allergens in a food samples or contaminants, such as environmental toxins, in water samples. Device and kit components may be conveniently assembled in a portable container and are amenable to actuation in most settings. The devices are simple to use, requiring a non-trained operator to simply add the sample to the device. Conveniently, the time it takes to detect the target analyte is very short. Thus, the devices and methods disclosed herein provide novel and useful means for point-of-care.

US Patent:

20190391143, Dec 26, 2019

Filed:

Jun 6, 2019

Appl. No.:

16/434100

Inventors:

- Oakland CA, US
Yin To Chiu - Irvine CA, US
Benjamin Ming Wu - San Marino CA, US
Garrett L. Mosley - Newport Beach CA, US

International Classification:

G01N 33/558
G01N 33/543

Abstract:

Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum. In addition, these devices and methods may be used to detect allergens in a food samples or contaminants, such as environmental toxins, in water samples. Device and kit components may be conveniently assembled in a portable container and are amenable to actuation in most settings. The devices are simple to use, requiring a non-trained operator to simply add the sample to the device. Conveniently, the time it takes to detect the target analyte is very short. Thus, the devices and methods disclosed herein provide novel and useful means for point-of-care.

US Patent:

20190033308, Jan 31, 2019

Filed:

May 25, 2018

Appl. No.:

15/990398

Inventors:

- Oakland CA, US
Yin To Chiu - Irvine CA, US
Benjamin M. Wu - San Marino CA, US
Garrett L. Mosley - Newport Beach CA, US

International Classification:

G01N 33/558
G01N 33/543

Abstract:

Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum. In addition, these devices and methods may be used to detect allergens in a food samples or contaminants, such as environmental toxins, in water samples. Device and kit components may be conveniently assembled in a portable container and are amenable to actuation in most settings. The devices are simple to use, requiring a non-trained operator to simply add the sample to the device. Conveniently, the time it takes to detect the target analyte is very short. Thus, the devices and methods disclosed herein provide novel and useful means for point-of-care.

US Patent:

20180259521, Sep 13, 2018

Filed:

Sep 2, 2016

Appl. No.:

15/756542

Inventors:

- Oakland CA, US
Yin To Chiu - Irvine CA, US
Benjamin M. Wu - San Marino CA, US
Garrett L. Mosley - Newport Beach CA, US

International Classification:

G01N 33/569
G01N 33/493
G01N 33/49
G01N 33/483

Abstract:

In various embodiments devices and methods for the detection and/or quantification of clinically relevant pathogens (e.g., bacteria, fungi, viruses, etc.) are provided. In certain embodiments the device comprises a lateral-flow assay that detects the bacterium at a concentration of less than about 6×10cells/mL, less than about 3×10cells/ml, less than about 1×10CFU/mL, or less than about 50 μg/mL. In certain embodiments the device comprises an aqueous two-phase system (ATPS) comprising a mixed phase solution that separates into a first phase solution and a second phase solution; and a lateral-flow assay (LFA). In certain embodiments the device comprises a flow-through system comprising a concentration component comprising an aqueous two-phase system (ATPS) comprising a mixed phase solution that separates into a first phase solution and a second phase solution; and a detection component disposed beneath said concentration component.

US Patent:

20180100854, Apr 12, 2018

Filed:

Oct 18, 2017

Appl. No.:

15/787638

Inventors:

- Oakland CA, US
Yin To Chiu - Irvine CA, US
Benjamin M. Wu - San Marino CA, US
Garrett L. Mosley - Newport Beach CA, US

International Classification:

G01N 33/558
G01N 33/543

Abstract:

Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum. In addition, these devices and methods may be used to detect allergens in a food samples or contaminants, such as environmental toxins, in water samples. Device and kit components may be conveniently assembled in a portable container and are amenable to actuation in most settings. The devices are simple to use, requiring a non-trained operator to simply add the sample to the device. Conveniently, the time it takes to detect the target analyte is very short. Thus, the devices and methods disclosed herein provide novel and useful means for point-of-care.

US Patent:

20150253320, Sep 10, 2015

Filed:

Mar 6, 2015

Appl. No.:

14/641022

Inventors:

- Oakland CA, US
Yin To Chiu - Sherman Oaks CA, US
Benjamin M. Wu - San Marino CA, US
Garrett L. Mosley - Los Angeles CA, US

International Classification:

G01N 33/543
G01N 33/569

Abstract:

Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum. In addition, these devices and methods may be used to detect allergens in a food samples or contaminants, such as environmental toxins, in water samples. Device and kit components may be conveniently assembled in a portable container and are amenable to actuation in most settings. The devices are simple to use, requiring a non-trained operator to simply add the sample to the device. Conveniently, the time it takes to detect the target analyte is very short. Thus, the devices and methods disclosed herein provide novel and useful means for point-of-care.