Ying Feng

US Patent:

20110190288, Aug 4, 2011

Filed:

Feb 3, 2011

Appl. No.:

13/020619

Inventors:

Daniel Chu - Santa Clara CA, US
Bing Wang - San Jose CA, US
Ying Feng - Fremont CA, US
Yuqiao Shen - Moraga CA, US
Leonard Edwin Post - Orinda CA, US

International Classification:

A61K 31/5025
A61P 35/00
A61P 43/00
A61K 31/5377

US Classification:

5142328, 514248

Abstract:

A compound having the structure set forth in Formula (I) and Formula (II):wherein the substituents Y, Z, A, B, R, R, R, Rand Rare as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions associated with a PTEN deficiency that are ameliorated by the inhibition of PARP activity.

US Patent:

20140066429, Mar 6, 2014

Filed:

Aug 21, 2013

Appl. No.:

13/972166

Inventors:

Bing Wang - San Jose CA, US
Ying Feng - Fremont CA, US
Yuqiao Shen - Moraga CA, US
Leonard Edwin Post - Orinda CA, US

Assignee:

BIOMARIN PHARMACEUTICAL INC. - Novato CA

International Classification:

C07D 487/06
A61N 5/10
A61K 45/06
A61K 31/5025
A61K 31/5377

US Classification:

51421021, 514248, 5142328, 600 1

Abstract:

A compound having the structure set forth in Formula (I) and Formula (II):wherein the substituents Y, Z, A, B, R, R, R, Rand Rare as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions associated with a PTEN deficiency that are ameliorated by the inhibition of PARP activity.

US Patent:

20190070189, Mar 7, 2019

Filed:

Aug 3, 2018

Appl. No.:

16/054899

Inventors:

- San Francisco CA, US
Bing WANG - San Jose CA, US
Ying FENG - Fremont CA, US
Yuqiao SHEN - Moraga CA, US
Leonard E. POST - Orinda CA, US

International Classification:

A61K 31/5377
C07D 487/06
A61N 5/10
A61K 31/5025
A61K 45/06

Abstract:

A compound having the structure set forth in Formula (I) and Formula (II):wherein the substituents Y, Z, A, B, R, R, R, Rand Rare as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions associated with a PTEN deficiency that are ameliorated by the inhibition of PARP activity.

US Patent:

20170337083, Nov 23, 2017

Filed:

Aug 7, 2017

Appl. No.:

15/670525

Inventors:

- Santa Clara CA, US
KINGSUM CHOW - Portland OR, US
YING FENG - Santa Clara CA, US
KHUN BAN - Hillsboro OR, US

Assignee:

Intel Corporation - Santa Clara CA

International Classification:

G06F 9/50
G06F 1/32
G06F 11/30
G06F 11/34

Abstract:

Generally, this disclosure provides systems, devices, methods and computer readable media for dynamic tuning of multiprocessor and multicore computing systems to improve application performance and scalability. A system may include a number of processing units (CPUs) and profiling circuitry configured to detect the existence of a scalability problem associated with the execution of an application on CPUs and to determine if the scalability problem is associated with an access contention or a resource constraint. The system may also include scheduling circuitry configured to bind the application to a subset of the total number of CPUs if the scalability problem is associated with access contention.

US Patent:

20170060635, Mar 2, 2017

Filed:

Sep 1, 2015

Appl. No.:

14/842359

Inventors:

- Santa Clara CA, US
KINGSUM CHOW - Portland OR, US
YING C. FENG - Santa Clara CA, US
KHUN BAN - Hillsboro OR, US

Assignee:

INTEL CORPORATION - Santa Clara CA

International Classification:

G06F 9/50
G06F 11/34
G06F 11/30
G06F 1/32

Abstract:

Generally, this disclosure provides systems, devices, methods and computer readable media for dynamic tuning of multiprocessor and multicore computing systems to improve application performance and scalability. A system may include a number of processing units (CPUs) and profiling circuitry configured to detect the existence of a scalability problem associated with the execution of an application on CPUs and to determine if the scalability problem is associated with an access contention or a resource constraint. The system may also include scheduling circuitry configured to bind the application to a subset of the total number of CPUs if the scalability problem is associated with access contention.

US Patent:

20170063652, Mar 2, 2017

Filed:

Sep 1, 2015

Appl. No.:

14/842438

Inventors:

- Santa Clara CA, US
KINGSUM CHOW - Portland OR, US
YING FENG - Santa Clara CA, US
KHUN BAN - Hillsboro OR, US
ZHIDONG YU - Shanghai, CN

Assignee:

INTEL CORPORATION - Santa Clara CA

International Classification:

H04L 12/26

Abstract:

Generally, this disclosure provides systems, devices, methods and computer readable media for estimation of application execution performance variations on a processor, without a priori knowledge of the application. A system may include network traffic data collection circuitry configured to sample a first network traffic statistic, from a network interface circuit associated with the processor, at a first sampling time interval during the application execution. The network traffic data collection circuitry may also be configured to sample a second network traffic statistic from the network interface circuit at a second sampling time interval during the application execution. The system may further include performance analysis circuitry configured to calculate a ratio of the first network traffic statistic to the second network traffic statistic and to estimate the application execution performance variation from the first sampling time interval to the second sampling time interval, wherein the estimation is proportional to the calculated ratio.

US Patent:

20150209363, Jul 30, 2015

Filed:

Mar 27, 2015

Appl. No.:

14/671944

Inventors:

- Novato CA, US
Bing Wang - San Jose CA, US
Ying Feng - Fremont CA, US
Yuqiao Shen - Moraga CA, US
Leonard Edwin Post - Orinda CA, US

International Classification:

A61K 31/5377
A61K 45/06
A61N 5/10
A61K 31/5025

Abstract:

A compound having the structure set forth in Formula (I) and Formula (II):wherein the substituents Y, Z, A, B, R, R, R, Rand Rare as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions associated with a PTEN deficiency that are ameliorated by the inhibition of PARP activity.