Ying H Li

US Patent:

8071107, Dec 6, 2011

Filed:

Sep 17, 2004

Appl. No.:

10/572638

Inventors:

Barton F. Haynes - Durham NC, US
Feng Gao - Durham NC, US
Bette T. Korber - Los Alamos NM, US
Beatrice H. Hahn - Birmingham AL, US
George M. Shaw - Birmingham AL, US
Denise Kothe - Birmingham AL, US
Ying Ying Li - Hoover AL, US
Julie Decker - Alabaster AL, US

Assignee:

Duke University - Durham NC
The Regents of the University of California - Oakland CA
The University of Alabama at Birmingham Research Foundation - Birmingham AL

International Classification:

A61K 39/21
C07H 21/04

US Classification:

4242081, 536 2372

Abstract:

The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.

US Patent:

20120087938, Apr 12, 2012

Filed:

Aug 23, 2011

Appl. No.:

13/137517

Inventors:

Barton F. Haynes - Durham NC, US
Feng Gao - Durham NC, US
Bette T. Korber - Oakland CA, US
Beatrice H. Hahn - Birmingham AL, US
George M. Shaw - Birmingham AL, US
Denise Kothe - Birmingham AL, US
Ying Ying Li - Birmingham AL, US
Julie Decker - Birmingham AL, US

Assignee:

DUKE UNIVERSITY - Durham NC
THE UNIVERSITY OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION - Birmingham AL
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

A61K 39/21
A61P 31/18
C12N 15/63
C07K 14/16
C12N 15/49

US Classification:

4241881, 530350, 536 2372, 4353201, 4242081

Abstract:

The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.

US Patent:

20210114029, Apr 22, 2021

Filed:

Oct 17, 2018

Appl. No.:

16/645285

Inventors:

- Durham NC, US
Ying Li - Durham NC, US
Jeff Motschman - Durham NC, US

International Classification:

B01L 3/00
C12M 3/06

Abstract:

The present disclosure comprises devices, systems and methods for organizing cells into an array, phenotyping them via image-based analysis over short or long durations, and conducting massively parallel barcoded genomic analysis with DNA barcodes that are present next to each cell.

US Patent:

20170053291, Feb 23, 2017

Filed:

Aug 17, 2015

Appl. No.:

14/828479

Inventors:

- Armonk NY, US
Subhendu DAS - Chapel Hill NC, US
Chitra DORAI - Chappaqua NY, US
Ying LI - Mohegan Lake NY, US

International Classification:

G06Q 30/00

Abstract:

In analyzing real-time order data, a surveillance system obtains historical orders data in a historical order stream labeled for a given rule, and for the given rule, determines optimal time and optimal data volume using a distribution model for the historical orders data. The surveillance system obtains real-time orders data from a real-time order stream within the optimal time or optimal data volume, determines that at least one real-time orders data violates the given rule, and validates that the real-time orders data indicates fraudulent activity. The surveillance system determines that the real-time orders data does not conform to the distribution model for the given rule, and in response, updates the distribution model using the real-time orders data, and updates the determination of the optimal time and optimal data volume using the updated distribution model and associating the updated optimal time and the updated optimal data volume with the given rule.