Ying N Su

US Patent:

20090118135, May 7, 2009

Filed:

Jun 2, 2008

Appl. No.:

12/131427

Inventors:

John C. Reed - Rancho Santa Fe CA, US
Kenneth Yip - San Diego CA, US
Eduard Sergienko - San Diego CA, US
Ying Su - San Diego CA, US

Assignee:

The Burnham Institute - La Jolla CA

International Classification:

C40B 30/04
G01N 33/68
G01N 33/50
C07K 1/113

US Classification:

506 9, 436 86, 435 792, 530402, 530409

Abstract:

An assay for determining compounds that inhibit activity of a BCl-2 protein, or affect conversion of Bcl-2 from an antiapoptotic to a proapoptotic form are described. In addition, compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified.

US Patent:

20160340324, Nov 24, 2016

Filed:

Dec 22, 2014

Appl. No.:

15/107275

Inventors:

Ying Su - La Jolla CA, US
- La Jolla CA, US

International Classification:

C07D 257/04
G06N 7/00
G06F 19/00
A61K 31/41
A61K 38/19

Abstract:

Embodiments provided herein relate to methods and compositions for treating cancer. Some embodiments relate to certain compounds having activity against retinoid X receptor-alpha (RXRα). Some embodiments included designing or identifying a compound that binds to human RXRa protein, such as the ligand binding domain (LBD) of human RXRa protein.

US Patent:

20150266842, Sep 24, 2015

Filed:

May 6, 2011

Appl. No.:

13/102475

Inventors:

Ying Su - San Diego CA, US
Hu Zhou - San Diego CA, US
Wen Liu - La Jolla CA, US
Pei-Qiang Huang - Xiamen, CN

International Classification:

C07D 295/112
C07D 213/55
C07C 255/57
C07C 57/62
C07C 59/72

Abstract:

Provided herein are methods and compositions related to a retinoid receptor-selective pathway. As described herein, this pathway can be targeted to manipulate a tumor microenvironment. For example, the methods and compositions described herein can be used to induce apoptosis in a cancer cell. Further, the compositions described herein, including Sulindac and analogs thereof, can be used to target this pathway for the treatment or prevention of cancer in human patients.