Yiping He

US Patent:

20020086310, Jul 4, 2002

Filed:

Aug 30, 2001

Appl. No.:

09/942487

Inventors:

Frank Fan - Collegeville PA, US
Yiping He - Collegeville PA, US
Jianzhong Huang - Collegeville PA, US
Xinhe Jiang - Collegeville PA, US
Damien McDevitt - Collegeville PA, US
Martin Rosenberg - Royersford PA, US
Annemarie St. John - King of Prussia PA, US

International Classification:

C12Q001/68
C12Q001/18

US Classification:

435/006000, 435/032000

Abstract:

A method of determining the cellular or genetic target of an antimicrobial compound includes cloning of a bacterial gene into an expression vector with an inducible promoter and determining whether increasing expression of the cloned gene in the cell will result in resistance to an antimicrobial compound. Also, the method can include incorporation of every gene of a bacterial strain into expression vectors having an inducible promoter, induction, treating with an antimicrobial compound, isolating the gene clone that confers cells resistant to the compound, and determining the identity of the resistant gene by various methods including DNA microarrays and gene sequencing.

US Patent:

20030181380, Sep 25, 2003

Filed:

Mar 10, 2003

Appl. No.:

10/385591

Inventors:

Warren Pear - Philadelphia PA, US
David Allman - Havertown PA, US
Yiping He - Philadelphia PA, US
David Izon - Wembley, AU
Jon Aster - Lexington MA, US

International Classification:

A61K038/17

US Classification:

514/012000

Abstract:

Provided are methods for manipulating aspects of lymphopoiesis by modulating and controlling Notch signaling, thereby providing treatment for diseases of the immune system. Accordingly, there are provided methods for selectively modulating T cell fate commitment of a common lymphoid progenitor at the expense of B cell fate commitment, and in the converse for selectively modulating B cell fate commitment of a common lymphoid progenitor at the expense of T cell fate commitment. Also provided are methods for treating patients suffering from a disease or disorder of T cell origin, or conversely of B cell origin. Further provided are methods for selectively killing B cells in a committed population of B cells, such as in a patient suffering from B cell leukemia or lymphoma; as well as methods for selectively killing T cells in a committed population of T cells such as in a patient suffering from diseases of T cell origin.

US Patent:

20040029201, Feb 12, 2004

Filed:

Jul 11, 2003

Appl. No.:

10/617988

Inventors:

Frank Fan - Collegeville PA, US
Yiping He - Collegeville PA, US
Jianzhong Huang - Collegeville PA, US
Xinhe Jiang - Collegeville PA, US
Damien McDevitt - Collegeville PA, US
Martin Rosenberg - Royersford PA, US
Annemarie St, John - King of Prussia PA, US

Assignee:

SmithKline Beecham Corporation and SmithKline Beecham p.I.c.

International Classification:

G01N033/574

US Classification:

435/007230

Abstract:

A method of determining the cellular or genetic target of an antimicrobial compound includes cloning of a bacterial gene into an expression vector with an inducible promoter and determining whether increasing expression of the cloned gene in the cell will result in resistance to an antimicrobial compound. Also, the method can include incorporation of every gene of a bacterial strain into expression vectors having an inducible promoter, induction, treating with an antimicrobial compound, isolating the gene clone that confers cells resistant to the compound, and determining the identity of the resistant gene by various methods including DNA microarrays and gene sequencing.

US Patent:

20060240505, Oct 26, 2006

Filed:

Jun 28, 2006

Appl. No.:

11/427043

Inventors:

Frank Fan - Collegeville PA, US
Yiping He - Collegeville PA, US
Jianzhong Huang - Collegeville PA, US
Xinhe Jiang - Collegeville PA, US
Damien McDevitt - Collegeville PA, US
Martin Rosenberg - Royersford PA, US
Annemarie St. John - King of Prussia PA, US

International Classification:

C12Q 1/18
C12N 1/21
C12N 15/74

US Classification:

435032000, 435471000, 435252300

Abstract:

A method of determining the cellular or genetic target of an antimicrobial compound includes cloning of a bacterial gene into an expression vector with an inducible promoter and determining whether increasing expression of the cloned gene in the cell will result in resistance to an antimicrobial compound. Also, the method can include incorporation of every gene of a bacterial strain into expression vectors having an inducible promoter, induction, treating with an antimicrobial compound, isolating the gene clone that confers cells resistant to the compound, and determining the identity of the resistant gene by various methods including DNA microarrays and gene sequencing.

US Patent:

20080205476, Aug 28, 2008

Filed:

Jul 13, 2007

Appl. No.:

11/777913

Inventors:

Manoj KANSKAR - Madison WI, US
Yiping HE - Madison WI, US
Steven H. MACOMBER - Tucson AZ, US

International Classification:

H01S 3/08
H01L 21/02

US Classification:

372 96, 372102, 438 22, 257E21002

Abstract:

A second-order multi-mode partial distributed feedback (p-DFB) laser having increased electrical-to-optical power conversion efficiency, stabilized wavelength and narrowed emission linewidth. The laser includes an abbreviated grating housed in the laser cavity that is separated from both the front-end and the back-end of the laser facets.

US Patent:

20080212635, Sep 4, 2008

Filed:

Feb 25, 2008

Appl. No.:

12/036809

Inventors:

Manoj Kanskar - Madison WI, US
Yiping He - Madison WI, US
Steve H. Macomber - Tucson AZ, US

Assignee:

Alfalight, Inc. - Madison WI

International Classification:

H01S 5/00
H01L 33/00

US Classification:

372 501, 372102, 438 32, 257E33001

Abstract:

The invention provides a grating for a distributed feedback laser having decreased diffraction loss with reduced +/−1 order diffraction and scattering loss resulting from the reduced imperfections in the grating fabrication. In various embodiments, the grating has a low duty cycle wherein the ratio of the length of the low-index portion ‘a’ to the length of the pitch of the grating ‘b’ is less than 0.5. Further, in some preferred embodiments, the invention includes a laser, the laser comprising a distributed feedback laser wherein the laser includes a grating having less diffraction and less scattering loss. In various exemplary embodiments, the grating is further a partial grating, thereby providing increased efficiency resulting from a decrease in first-order diffraction loss due to the grating being separated from the front and rear facets and in some exemplary embodiments being situated at the area of lowest electric filed.